|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 5 |
| 3 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 3 |
| 4 | Effect of immediate or delayed loading following immediate placement of implants with a modified surface显示文摘 | Linares A Mardas N Dard M Donos N | 2010 | Clin Oral Implants Res2010，，： | 1 |
| 5 | An evaluation of genetic distances for use with microsatelliteloci显示文摘 | Goldstein D B Linares A R Cavalli-Sforza L L | 1995 | Genetics1995，139，1： | 1 |
| 6 | Autoimmune thrombocytopenia associated with hepatitis C virus infection 显示文摘 | Blanquer A Linares M | 1998 | Acta Haematologica1998，99，4： | 1 |
| 7 | Chronic idiopathic thrombocytopenic purpura in the elderly显示文摘 | Linares M Cervero A Colomina P | 1995 | Acta Haematol1995，93，24： | 1 |
| 8 | Robotic and laparoscopic surgery: cost and training显示文摘 | Patel HR Linares A Joseph JV | 2009 | Surg 0ncol2009，18，3： | 1 |
| 9 | Manipulating protein acetyla- tion in breast cancer:a promising approach in combination with hormo- nal therapies? 显示文摘 | Linares A Dalenc F Balaguer P | 2011 | J Biomed Biotechnol2011，2011，85： | 1 |
| 10 | Benefits and limitations of parametric design implementation in helicopter gearbox design phase显示文摘 | Mermoz E Linares J M Bernard A | 2011 | Manufacturing Technology2011，60，1： | 1 |
| 11 | An evaluation of genetic distances for use with microsatellite loci 显示文摘 | Goldstein D B Linares A R Cavalli-Sforza L L | 1995 | Genetics1995，139，： | 1 |
| 12 | A radiological study of the cervical alterations in down syndrome:new findings on computerized tomography and three dimensional reconstructions 显示文摘 | Cros T Linares R Castro A | 2000 | Rev Neurol2000，30，12： | 1 |
| 13 | Hypothermia for the treatment of ischemic and hemorrhagic stroke 显示文摘 | Guillermo Linares Stephan A | 2009 | Crit Care Med2009，37，7： | 1 |
| 14 | Quantitative analysis of enalapril by ^1H NMR spectroscopy in tablets 显示文摘 | Zoppi A Linares M Longhi M | 2005 | J Pharm Biomed Anal2005，37，3： | 1 |
| 15 | Breast conservation therapy with concomitant breast reduction in large-breasted women 显示文摘 | Stolier A Allen R Linares L | 2003 | Breast J2003，9，4： | 1 |
| 16 | A randomized trial on the effect of tubing changes on hub contamination and catheter sepsis during parenteral nutrition显示文摘 | Sitges- Serra A Linares J Perez JL | 1985 | Journal of Parenteral and Enteral Nutrition1985，9，： | 1 |
| 17 | An evaluation of genetic distances for use with microsatellite loic 显示文摘 | Coldslein D B Linares A R Feldman MW | 1995 | Genetics1995，139，1： | 1 |
| 18 | Influence of pore structure and surface chemistry on electric double layer capacitance in non-aqueous electrolyte显示文摘 | Lozano Castello D Cazorla Amoro D Linares Solano A | | 0，，09： | 1 |
| 19 | Calcium-carbon interaction study:its importance in the carbongas reactions显示文摘 | Cazorla A D Linares S A Salinas M D L C | 1991 | Carbon1991，29，3： | 1 |
| 20 | Heterogeneous sulfonation of blend systems based on hydrogenated poly(butadiene styrene) block copolymer: Electrical and structural characterization显示文摘 | Bashir H Linares A Acosta J L | 2001 | Solid State Ionies2001，139，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员