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| 1 | Human embryonic stem cells-derived endothelial cell therapy facilitates kidney regeneration by stimulating renal resident stem cell proliferation in acute kidney injury显示文摘Endothelial cell therapy has been implicated to enhance tissue regeneration and vascularization in ischemic kidney. However, no published study has yet examined direct effects of endothelial cell treatment in kidney recovery. This study investigated the therapeutic efficacy of endothelial cells in a mouse model with acute kidney injury (AKI). Thus, human embryonic stem cells-derived endothelial cells (hESC-ECs) labeled with a reporter system encoding a double fusion reporter gene for firefly luciferase (Fluc) and green fluorescent protein (GFP) were characterized by Fluc imaging and immunofluoresence staining. Cultured hESC-ECs (1×106) were injected into ischemic kidney shortly after AKI. Survival of the transplanted hESC-ECs was monitored in vivo from day 1 to 14 after endothelial cell transplantation and potential impact of hESC-EC treatment on renal regeneration was assessed by histological analyses. We report that a substantial level of bioluminescence activity was detected 24 h after hESC-EC injection followed by a gradual decline from 1 to 14 d. Human ESC-ECs markedly accelerated kidney cell proliferation in response to ischaemia-induced damage, indicated by an elevated number of BrdU+ cells. Co-expression of Sca-1, a kidney stem cell proliferation marker, and BrdU further suggested that the observed stimulation in renal cell regeneration was, at least in part, due to increased proliferation of renal resident stem cells especially within the medullary cords and arteriole. Differentiation of hESC-ECs to smooth muscle cells was also observed at an early stage of kidney recovery. In summary, our results suggest that endothelial cell therapy facilitates kidney recovery by promoting vascularization, trans-differentiation and endogenous renal stem cell proliferation in AKI. | JIA XiaoHua L He LI Chen FENG GuoWei YAO XinPeng MAO LiNa KE TingYu CHE YongZhe XU Yong LI ZongJin KONG DeLing | 2013 | Chinese Science Bulletin2013，58，23： | 4 |
| 2 | Hierarchical coordination in virtual enterprise infrastructure显示文摘 | Matos L M Afsamancsh H Lina C | 1999 | Journal of Intelligent and Robotic Systenm1999，26，1： | 2 |
| 3 | An Introduction to Multisensor Data Fusion显示文摘 | Hall D L Linas J | 1997 | Proceedings of IEEE1997，85，1： | 1 |
| 4 | Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node,not the lungs显示文摘 | Wolf AJ Desvignes L Linas B | | 0，，01： | 1 |
| 5 | Nanosized ALPO4-5 molecular sieves and ultrathin films prepared by microwave synthesis 显示文摘 | Mintova S Bein T Lina L | 1998 | Chemistry of Materials1998，10，： | 1 |
| 6 | Process intensification technologies in continuous biodiesel production显示文摘 | Qiu Zheyan Zhao Lina Weatherley L | 2010 | Chemical Engineering and Processing2010，49，4： | 1 |
| 7 | Current perspectives on milk hyper-sensitivity显示文摘 | Leea P Lina L and Esa-Matti L | 1999 | Trend in food science & technology1999，，10： | 1 |
| 8 | Impact ofChi-Chi Earthquakeon the Occurrence of Landslides and Debrisflows:Example from the Chenyulan Riverwatershed,Nantou,Taiwan显示文摘 | Lina C W Shieh C L Yuan B D | 2003 | Engineering Geology2003，71，： | 1 |
| 9 | Integrating on-line process control and imperfect corrective mainte- nance and economical design 显示文摘 | LINA L H ROBERTO C Q | 2012 | European Jour-nal of Operational Research2012，222，2： | 1 |
| 10 | Combined treatment of etanercept and MTX reverses Th1/Th2,Th17/Treg imbalance in patients with rheumatoid arthritis显示文摘 | Lina C Conghua W Nan L | 2011 | J Clin Immunol2011，31，4： | 1 |
| 11 | Allylic oxidation of cyclohexene over silica immobilized iron tetrasulfophthalocyanine 显示文摘 | Lina M Gonzalez Aida L Villa de Consuelo Montes de C | 2006 | Tetrahedron Letters2006，47，36： | 1 |
| 12 | Levels of circulating Thl7 cells and regulatory T cells in ankylosing spondylitis patients with an inadequate response to anti-TNF-alpha therapy 显示文摘 | Xueyi L Lina C Zhenbiao W et a | 2013 | J Clin Immunol2013，33，： | 1 |
| 13 | An introduction to multisensor data fusion显示文摘 | Linas J | 1997 | Proc IEEE1997，85，1： | 1 |
| 14 | An Introduction to Muhisensor Data Fusion显示文摘 | HALL D L LINAS J | 1997 | Proceedings of the IEEE1997，85，1： | 1 |
| 15 | Gas diffusion layer for proton exchange membrane fuel cells--a review 显示文摘 | Cindrella L Kannana A M Lina J F Saminathana K Hoc Y Lind C W Wertze J | 2009 | Journal of Power Sources2009，194，： | 1 |
| 16 | Microbial diversity in sediments collected from the deepest cold - seep area the Japan Trench显示文摘 | Lina L Kato C Horikoshi K | 1999 | Marine Biotechnology1999，1，4： | 1 |
| 17 | Bakerr's yeast mitochondria,gassing power and freeze-thaw tolerance in dough显示文摘 | P Gé linas L Savoie N Rodrigue | 1996 | FoodMicrobiology1996，13，： | 1 |
| 18 | An Introduction to Multisensor Data Fusion显示文摘 | Hall D L Linas J | 1997 | Proceedings of the IEEE1997，85，10： | 1 |
| 19 | Expression of a spider venom peptide in transgenic tobacco confers insect resistance显示文摘 | Herndndez Campuzano B Sudrez R Lina L | 2009 | Toxicon2009，53，： | 1 |
| 20 | The Properties of Ti-doped ZnO Films Deposited by Simultaneous RF and DC Magnetron Sputtering显示文摘 | Lina S S Huangga J L Sajgalik P | 2005 | Surf Coat Technol2005，191，： | 1 |
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