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| 1 | Effect of Helicobacter pylori on gastric epithelial cells显示文摘The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori(H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori. | Shatha Alzahrani Taslima T Lina Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 15 |
| 2 | Immune evasion strategies used by Helicobacter pylori显示文摘Helicobacter pylori(H. pylori) is perhaps the most ubiquitous and successful human pathogen, since it colonizes the stomach of more than half of humankind. Infection with this bacterium is commonly acquired during childhood. Once infected, people carry the bacteria for decades or even for life, if not treated. Persistent infection with this pathogen causes gastritis, peptic ulcer disease and is also strongly associated with the development of gastric cancer. Despite induction of innate and adaptive immune responses in the infected individual, the host is unable to clear the bacteria. One widely accepted hallmark of H. pylori is that it successfully and stealthily evades host defense mechanisms. Though the gastric mucosa is well protected against infection, H. pylori is able to reside under the mucus, attach to gastric epithelial cells and cause persistent infection by evading immune responses mediated by host. In this review, we discuss how H. pylori avoids innate and acquired immune response elements, uses gastric epithelial cells as mediators to manipulate host T cell responses and uses virulence factors to avoid adaptive immune responses by T cells to establish a persistent infection. We also discuss in this review how the genetic diversity of this pathogen helps for its survival. | Taslima T Lina Shatha Alzahrani Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 7 |
| 3 | Pathophysiology of hypertension during preeclampsia linking placental with endothelial dysfunction显示文摘 | Granger J Alexander BT Linas MT | 2001 | Hypertension2001，38，32： | 1 |
| 4 | Development of new features of ant colony optimization for flowshop scheduling显示文摘 | LUB C Y SHYUC S J | 2008 | International Journal of Production Economics2008，112，2： | 1 |
| 5 | Protein enrichment of potato pro- cessing waste through yeast fermentation 显示文摘 | Ge' linas P Barrette J | 2007 | Bioresource Technology2007，98，5： | 1 |
| 6 | An Introduction to Multisensor Data Fusion显示文摘 | Hall D L Linas J | 1997 | Proceedings of IEEE1997，85，1： | 1 |
| 7 | Cycling and composition of organic matter in terrestrial and marine ecosystems显示文摘 | Baldock J A Masiello C A Gélinas Y | | 0，，1： | 1 |
| 8 | Protein enrichment of potato processing waster through yeast fermentation显示文摘 | P G e linas J Barrette | 2007 | Bioresource Technology2007，，9： | 1 |
| 9 | Public health awareness of e-merging zoonotic viruses of bats:a European perspective显示文摘 | Van P W Lina P H Kramps J A | 2006 | Vector Borne Zoonotic Dis2006，6，4： | 1 |
| 10 | Leaching characteristics of heavy metals and brominated flame retardants from waste printed circuit boards显示文摘 | ZHOU X Y GUO J LINA K F | 2013 | Journal of Hazardous Materials2013，，246247： | 1 |
| 11 | A case study in a two-stage hybrid flow shop with setup time and dedicated machines显示文摘 | LINA H T LIAO C J | 2003 | International Journal of Production Economics2003，86，： | 1 |
| 12 | Biomarkers for Severity of Neonatal Hypoxic-Ischemic Encephalopathy and Outcomes in Newborns Receiving Hypothermia Therapy显示文摘 | Lina F Chalak Pablo J Sánchez Beverley Adams-Huet | 2014 | The Journal of Pediatrics2014，164，3： | 1 |
| 13 | Image processing with complex Daubechies wavelets显示文摘 | Lina J | 1996 | Journal of Mathematical imaging and vision1996，7，3： | 1 |
| 14 | The measurement of fatigue:a newinstrument显示文摘 | Joseph E Schwartz Lina J | 1993 | Journal of Psychosomatic Research1993，37，7： | 1 |
| 15 | Mycobacterium tubercu- losis infects dendritic cells with high frequency and impairs their function in vivo显示文摘 | Wolf A J Linas B Trevejo-Nurtez GJ | 2007 | J Immunol2007，179，4： | 1 |
| 16 | A contemporary study into the application of neural network techniques employed to automate CAD/CAM integration for die manufacture显示文摘 | DING Lina MATTHEWS J | 2009 | Computers & Ind Eng2009，57，4： | 1 |
| 17 | Biopsy proven isolated CNS vasculitis, much vaunted but rarely seen: 20 years retrospective review of brain biopsis显示文摘 | Castle J Linas R Wityk R | 2008 | Stroke2008，39，： | 1 |
| 18 | The evolution and maintenance of virulence in Staphylococcus aureus : a role for host-to-host transmission 显示文摘 | Massey R C Horsburgh M J Lina G | 2006 | Nature2006，4，12： | 1 |
| 19 | An introduction to multisensor data fusion显示文摘 | Linas J | 1997 | Proc IEEE1997，85，1： | 1 |
| 20 | An Introduction to Muhisensor Data Fusion显示文摘 | HALL D L LINAS J | 1997 | Proceedings of the IEEE1997，85，1： | 1 |
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