共被期刊论文引用了4次
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| 1 | 重症全身性感染患者急性肾损害超声早期诊断的意义显示文摘目的重症全身感染的患者治疗期间观察对于急性肾损害使用超声波法诊断的效果,为临床治疗提供参考依据。方法从2012年1-12月随机选取100例患者进行研究;通过超声波及实验室检测血肌酐两种方法进行急性肾损害早期的诊断,超声波测量肾脏的大小、肾脏动脉的收缩期和舒张期的峰值流速、肾脏的阻力指数等,实验室检测血肌酐值;比较两种诊断方法对于急性肾损害诊断的敏感性。结果使用超声波检测肾脏的大小、肾脏动脉收缩期和舒张期的峰值流速、肾脏的阻力指数、肾血管搏动指数等指标,结果有53例患者诊断急性肾损害,血肌酐有两例检出急性肾损害。结论在重症全身性感染患者进行急性肾损害的诊断中,应用超声波法取得了很好的诊断结果,能够更早发现患者的病情变化,为治疗争取更多的时间,值得广泛的推广应用。 | 陈君耀 谢志刚 易惠明 | 2014 | 中华医院感染学杂志2014，24，24： | 2 |
| 2 | Metformin targets liver tumor-initiating cells through the PI3K/Akt/mTOR survival pathway显示文摘Liver tumor-initiating cells(T-ICs) are thought to be inherently resistant to the cytotoxic effects of chemotherapy, and can self-renewal and maintain tumor-initiating potential. Therefore, effective anticancer research strategies should target the unique properties of T-ICs. In this study, we found that metformin, a first-line drug of choice for the treatment of type 2 diabetes, inhibited liver T-ICs both in vivo and in vitro. Metformin inhibited the formation of hepatospheres and epithelial-specific antigen-positive(ESA,CD133?) cell colonies by hepatocellular carcinoma(HCC)cell lines. Metformin also downregulated the expression of several T-IC-related genes which are involved in the signaling pathways, governing the self-renewal, proliferation and differentiation of T-ICs. Furthermore, the targeting of liver T-ICs by metformin was PI-3-kinase-Akt-mTOR(PI3K/Akt/mTOR)-pathway dependent. The PI3K/Akt/mTOR inhibitor LY294002 and rapamycin abolished the inhibitory effect of metformin on CD133?cells, and the PI3K/Akt/mTOR stimulator EGF promoted the inhibitory effect of metformin on CD133?cells. Metformin also dramatically decreased the tumor volume and number of CD133 expressing tumor cells in a xenograft mouse model. Metformin exerted a synergistic effect with cisplatin to target both T-ICs and non-T-ICs, and resulted in the smallest tumor volume and lowest number of CD133 expressing tumor cells. This study indicates that the antidiabetic drug metformin could potentially be used in combination therapy with chemotherapeutic agents to improve the treatment of liver cancer. | Fen Lin Wei Yan Gang Song Wen Ting Tianhui Hu Guoyang Wu | 2014 | Chinese Science Bulletin2014，59，28： | 1 |
| 3 | 水凝胶作为递送基质促进急性肾损伤修复再生的研究进展显示文摘急性肾损伤(AKI)是临床上常见的急危重症,具有高发病率和高病死率等特点,已逐渐成为全球性的公共卫生问题。目前应用于临床上行之有效的治疗方法仍仅限于透析和肾移植,但因存在诸多缺点而受限。过去的几十年来,通过直接将干细胞、生长因子或治疗药物递送至肾脏损伤部位的治疗策略取得了一定进展,但由于干细胞的存活率偏低或外源性生长因子、治疗药物的递送效率等问题限制了其修复疗效。因此,部分研究者选取水凝胶为载体向损伤部位靶向递送干细胞、生长因子或治疗药物,有效延长其在肾内的停留时间,显著增强AKI的修复效果。本文主要对以水凝胶为基质递送干细胞、生长因子或治疗药物治疗AKI的研究进展进行综述,并对该研究未来的发展方向进行展望。 | 田绍强 | 2022 | 当代医学2022，28，11： | 0 |
| 4 | From Chinese Science Bulletin to Science Bulletin: celebrate the coming 50th birthday显示文摘As the only multidisciplinary journal supervised by Chinese Academy of Sciences and the National Natural Science Foundation of China,Science Bulletin will usher in its50th anniversary in 2016.A fifty-year history for a journal is always remarkable.However,the more important reason to celebrate besides the great age is:the fifty-year old journal continues to be vigorous and influential. | Xuming Jia Rui An Xiao-Ya Chen | 2015 | Science Bulletin2015，60，24： | 0 |
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