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| 1 | Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP显示文摘胸腺嘧啶 DNA glycosylase (TDG ) ,开始 G/T 和 G/U 的修理的酶错配,最近被发现 crucialin 胚胎维持 epigenetic 稳定性并且便于活跃 DNA demethylation 的开发。这里,我们在作为 -catenin/TCFs 建筑群的 transcriptional 激活剂发信号的 Wnt 报导 TDG 的 novelrole。我们 TDG 绑在 thetranscriptional 因素家庭 LEF1/TCFs 并且加强的数据表演 -catenin/TCFs transactivation,当 TDG 弄空压制 Wnt3a-stimulatedreporter 活动或目标基因抄写时。下次,我们显示出那 CBP,已知的激活剂,也为在目标倡导者上形成合作建筑群的 TDG functionthrough 被要求。而且,有在人的冒号 cancertissue 的 TDG 层次的举起,并且 TDG 击倒禁止冒号房间的增长。总的来说,我们的结果表明作为新激活剂, TDG 支持 -catenin/TCFs transactivation 并且机能上地在正规 Wnt 发信号与 CBP 合作。 | Yingying Jia Fen Nie Aiying Du Zhangcheng Chen Yuanbo Qin Tao Huang Xiaomin Song Lin Li | 2014 | Journal of Molecular Cell Biology2014，8，3： | 5 |
| 2 | Optical sampling system using periodically-poled lithium niobate waveguide and nonlinear polarization rotation mode-locked fiber laser显示文摘光采样系统的一个新奇图案被在杆得周期性地的锂 niobate (PPLN ) 使用和频率产生(SFG ) 开发了当光采样搏动,波导和使用的被动锁模式的纤维激光搏动。系统与 19.3 m 和被被动 modelock 纤维激光基于非线性的极化旋转(NPR ) 产生的 151 fs 采样脉搏的伪阶段匹配时期用 30 公里长度 PPLN 完成了高时间的分辨率和高敏感。10 Gbit/s non-return-to-zeros (NRZ ) 的清楚的眼睛图假散乱二进制代码顺序(PRBS ) 光信号被这个系统成功地重建。 | Jian LI Aiying YANG Lin ZUO Junsen LAI Yunan SUN | 2012 | Frontiers of Optoelectronics2012，5，2： | 2 |
| 3 | Ammonium sulfate gradient loading of brucine into liposomes: effect of phospholipid composi- tion on entrapment effiency and physicochemical properties in vitro显示文摘 | CHEN J LIN AII CHEN ZP | 2010 | Drug Dev lnd Pharm2010，36，3： | 1 |
| 4 | A Method of Peak Detecting for Nanosecond Pulse in Optical Performance Monitoring System显示文摘In optical performance monitoring system,the analog to digital converter is needed to detect the peak of nanosecond pulse and get the signal envelope.A scheme based on a designed anti-aliasing filter and analog to digital converter is proposed to broaden the nanosecond pulse and make it easier for the analog to digital converter to catch the peak of the nanosecond pulse.The experimental results demonstrate that,with the proposed scheme,the optical performance system needs less time to get the recovered eye-diagram of high speed optical data signal,and is robust to phase mismatch in the analog to digital converter circuit. | FENG Lihui ZHANG Qing LIU Xiang ZUO Lin YANG Aiying | 2014 | China Communications2014，11，2： | 0 |
| 5 | Synthesis and Gelation Capability of Fmoc and Boc Mono-substituted Cyclo(L-Lys-L-Lys)s显示文摘 | ZONG Qianying GENG Huimin YE Lin ZHANG Aiying SHAO Ziqiang FENG Zengguo | 2016 | Chemical Research in Chinese Universities2016，32，3： | 0 |
| 6 | Polyrotaxane-based triblock copolymers synthesized via ATRP of N-isopropylacrylamide initiated from the terminals of polypseudorotaxane of Br end-capped pluronic 17R4 and β-cyclodextrins显示文摘Thermo-responsive polyrotaxane (PR)-based triblock copolymers were synthesized via the atom transfer radical polymerization (ATRP) of N-isopropylacrylamide initiated with self-assemblies made from a distal 2-bromoisobutyryl end-capped Pluronic 17R4 (PPO14-PEG24-PPO14) with a varying amount of β-cyclodextrins (β-CDs) in the presence of Cu(I)Cl/PMDETA at 25 °C in aqueous solution. The molecular structure was characterized by means of H NMR, FTIR, WXRD, GPC, TGA and 1 DSC analyses. About half of β-CDs are still entrapped on the Pluronic 17R4 chain while the number of incorporated NIPAAm monomers is nearly a double feed value in the resulting copolymers. The aggregate morphologies in aqueous solution were evidenced by TEM observations. A two-step thermo-responsive transition arising from a combination of a polypseudorotaxane middle block with poly(N-isopropylacrylamide) flanking blocks was also demonstrated by turbidity measurements. Given their thermo-responsive behavior in aqueous solution, these PR-based triblock copolymers show the potential to be used as smart materials for the controlled drug delivery systems, biosensors, and the like. | LI Shuo WANG Jin GAO Peng YE Lin ZHANG AiYing FENG Zeng-Guo | 2012 | Science China Chemistry2012，55，6： | 0 |
| 7 | The multifunctional wound dressing with core-shell structured fibers prepared by coaxial electrospinning显示文摘 | Qilin WEI Feiyang XU Xingjian XU Xue GENG Lin YE Aiying ZHANG Zengguo FENG | 2016 | Frontiers of Materials Science2016，10，2： | 0 |
| 8 | Gelation capability of cysteine-modified cyclo(L-Lys-L-Lys)s dominated by Fmoc and Trt protecting groups显示文摘A series of symmetrical peptidomimetics(3–8) based on cysteine-modified cyclo(L-Lys-L-Lys)s were synthesized, and their gelation capability in organic solvents was dominated by fluorenylmethyloxycarbonyl(Fmoc) and triphenylmethyl(Trt) protecting groups and the exchange of thiol-to-disulfide as well. The peptidomimetics holding Trt(3 and 4) showed no gel performance, while the Fmoc groups promoted 5 and 6 to give rise to thermo-reversible organogels in a number of organic solvents. The self-assembled fibrillar networks were distinctly evidenced in the organogels by transmission electron microscopy(TEM) and scanning electron microscopy(SEM) observations. Fourier transform infrared spectroscopy(FT-IR) and fluorescence analyses revealed that the hydrogen bonding and ?-? stacking play as major driving forces for the self-assembly of these organogelators. A ?-turn secondary structure was deduced for the organogel of 6 by virtue of X-ray diffraction, FT-IR and circular dichroism(CD) measurements, and an interdigitated bilayer structure was also presented. | Huimin Geng Qianying Zong Jie You Lin Ye Aiying Zhang Ziqiang Shao Zengguo Feng | 2016 | Science China Chemistry2016，59，3： | 0 |
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