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| 1 | Use of second generation contrast-enhanced ultrasound in the assessment of focal liver lesions显示文摘Ultrasound (US) is often the first imaging modality employed in patients with suspected focal liver lesions. The role of US in the characterisation of focal liver lesions has been transformed with the introduction of specific contrast media and the development of specialized imaging techniques. Ultrasound now can fully characterise the enhancement pattern of hepatic lesions, similar to that achieved with contrast enhanced multiphasic computed tomography (CT) and magnetic resonance imaging (MRI). US contrast agents are safe, well-tolerated and have very few contraindications. Furthermore, real-time evaluation of the vascularity of focal liver lesions has become possible with the use of the newer microbubble contrast agents. This article reviews the enhancement pattern of the most frequent liver lesions seen, using the second generation US contrast media. The common pitfalls for each type of lesion are discussed. The recent developments in US contrast media and specific imaging techniques have been a major advance and this technique, in view of the intrinsic advantages of US, will undoubtedly gain popularity in the years to come. | Stanislas HX Morin Adrian KP Lim eremy FL Cobbold Simon D Taylor-Robinson | 2007 | World Journal of Gastroenterology2007，13，45： | 16 |
| 2 | 探讨卵巢和子宫的子宫内膜样癌、伴透明细胞改变子宫内膜样癌和透明细胞癌的免疫表型显示文摘准确的鉴别透明细胞癌和子宫内膜样癌有着非常重要的临床意义,部分内膜样癌伴透明细胞改变,可以模拟透明细胞癌。作者评估一组免疫组化标志物能否帮助鉴别这几种肿瘤。64例透明细胞癌(40例来源卵巢和24例来源子宫)、34例内膜样癌(21例来源卵巢和13例来源子宫)及34例内膜样癌伴透明细胞改变(6例来源卵巢和28例来源子宫),免疫组化标记HNF1β、BAF250a、Napsin A、ER和PR,并对免疫组化着色强度和范围进行评估。 | Lim D Ip P P Cheung A N 魏建国 许春伟 | 2015 | 临床与实验病理学杂志2015，31，9： | 9 |
| 3 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 4 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 5 | Non-invasive splenic parameters of portal hypertension:Assessment and utility显示文摘BACKGROUND Portal hypertension is a major complication of cirrhosis that is associated with significant morbidity and mortality.The present gold-standard method to risk stratify and observe cirrhosis patients with portal hypertension is hepatic venous pressure gradient measurement or esophagogastroduodenoscopy.However,these methods are invasive,carry a risk of complications and are associated with significant patient discomfort.Therefore,non-invasive splenic parameters are of clinical interest as potential useful markers in determining the presence of portal hypertension.However,diagnostic accuracy and reproducibility remains unvalidated.AIM To assess the diagnostic accuracy of spleen stiffness,area and diameter in predicting the presence of portal hypertension.METHODS Of 50 patients with varying liver disease pathologies were prospectively recruited from the St.Mary’s Hospital Liver Unit in London;25 with evidence of portal hypertension and 25 with no evidence of portal hypertension.Liver stiffness,spleen stiffness,spleen diameter and spleen area were measured using the Philips Affiniti 70 elastography point quantification point shear wave elastography system.The aspartate aminotransferase-to-platelet-ratio-index(APRI)score was also calculated.Performance measures,univariate and multivariate logistic regression were used to evaluate demographic,clinical and elastography variables.Interclass correlation coefficient was used to determine the reproducibility of splenic area and diameter.RESULTS On univariate and individual performance,platelet count[area under the receiver operating characteristic(AUROC)0.846,P value<0.001],spleen area(AUROC 0.828,P value=0.002)and APRI score(AUROC 0.827,P value<0.001)were the most accurate variables in identifying the presence of portal hypertension.On multivariate logistic regression models constructed,the combination of spleen area greater than 57.90 cm2 and platelet count less than 126×10^9 had 63.2%sensitivity and 100%specificity,100%positive predictive value and 100%negative predictive value.An alternative combination of spleen stiffness greater than 29.99 kPa and platelet count less than 126×10^9 had 88%sensitivity,75%specificity,78.6%positive predictive value and 85.7%negative predictive value.An interclass correlation coefficient value of 0.98(95%CI:0.94-0.99,P value<0.001)and 0.96(95%CI:0.91-0.99,P value<0.001)were determined for inter-operator variability for spleen area and diameter respectively.CONCLUSION Spleen area,spleen stiffness and platelet count may be useful markers to assess the presence of portal hypertension in patients of various etiologies. | Ayesha Karim Ahmad Sebastiana Atzori James Maurice Simon D Taylor-Robinson Adrian KP Lim | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 6 | Role of microbubble ultrasound contrast agents in the non-invasive assessment of chronic hepatitis C-related liver disease显示文摘长期地感染丙肝病毒的病人经常得长期的肝疾病,对肝损伤的严厉的评价在认为病毒的根除是治疗以前被要求。这篇文章检验从标准答案肝活体检视当前可得到的各种各样的评价方法到血清学的标记和成像。超声是在临床的实践的最广泛地使用的成像形式之一并且已经是为肝疾病的一个首要的诊断工具。Microbubble 超声对比代理人允许更高的分辨率要获得的图象和对要执行的微脉管的变化的功能的评价。在确定的这些代理人的角色肝的损害的状态作为与丙肝在病人决定肝疾病的阶段和等级的一个可行方法被讨论。尽管当前限制了到专家中心,提高对比的超声将不可避免地在临床的背景增加的微水泡的可获得性。 | Scott Grier Adrian KP Lim Nayna Patel Jeremy FL Cobbold Howard C Thomas Isobel J Cox Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，22： | 2 |
| 7 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，： | 2 |
| 8 | The unimportance of phase in speech enhancement 显示文摘 | Wang D L Lim J S | 1982 | IEEE Transactions on Acoustics Speech Signal Processing1982，30，4： | 2 |
| 9 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 10 | Voidage and particle velocity profiles in a spout-fluid bed 显示文摘 | Pianarosa D L Freitas L Lim C J | 2000 | The Canadian Journal of Chemical Engineering2000，78，2： | 2 |
| 11 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 12 | Effect of carbon nanotube addition on tribological behavior of UHMWPE显示文摘 | Zoo Y S An J W Lim D P | 2004 | Tribology Letters2004，16，： | 1 |
| 13 | Combustion reactivity and morphological change in coal chars:Effect of pyrolysis temperature,heating rate and pressure显示文摘 | CAI H-Y GELL A J CHATZAKIS I N LIM J-Y DUGWELL D R KANDIYDT I R | 1996 | Fuel1996，75，1： | 1 |
| 14 | Effect of Mg17Al12 precipitate on Corrosion behavior of AZ91D magnesium alloy 显示文摘 | KO Y J YIM C D LIM J D SHIN K S | 2003 | Mater Science Forum2003，，： | 1 |
| 15 | Changes in bile duets after radiofrequency ablation of hepatocellular carcinoma: Frequency and clinical significance显示文摘 | Kim SH Lim HK Choi D | 2004 | American Journal of Roentgenology2004，183，12： | 1 |
| 16 | Cancer-specific loss of hu- man beta-defensin-1 in human renal and prostatic carcinomas显示文摘 | Donald C D Sun S Q Lim S D | 2003 | Lab Invest2003，83，： | 1 |
| 17 | Comparing Gompertz and Rich- ards functions to estimate freezing injury in Rhododendron using electro- lyte leakage 显示文摘 | LIM C C ARORA R TOWNSEND E D | 1998 | American Society for Horticultural Science1998，123，2： | 1 |
| 18 | A comparative study on catalyst deactivation of nickel and cobalt incorporated MCM-41 catalysts modified by platinum in methane reforming with carbon dioxide 显示文摘 | LIU D P CHEO W N E LIM Y W Y BORGN A LAU R YANG Y H | 2010 | Catalysis Today2010，154，34： | 1 |
| 19 | Acute and long-term safetyevaluation of a novel IH636 grape seed proanthocyanidin extract显示文摘 | Ray S Bagchi D Lim PM e( al | 2001 | Res Commun Mol Pathol Pharmacol2001，109，34： | 1 |
| 20 | Cyclic thermomechanical behavior of a polyerystalline pseudoelastic shape memory alloy 显示文摘 | Lim T J McDowell D L | 2002 | Journal of the Mechanics and Physics of Solids2002，50，3： | 1 |
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