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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Large dimensional covariance matrix estimation via a factor model显示文摘 | Fan J Fan Y Lii J | 2008 | Journal of Economet- rics2008，147，： | 1 |
| 3 | Primary medication non-adherence:analysis of 195,930electronic prescriptions显示文摘 | Fischer MA Stedman MR Lii J | 2010 | Journal of General Internal Medicine2010，25，4： | 1 |
| 4 | Shift of path- ways during initiation of thermophilie methanogenesis at different initial pH显示文摘 | Hao L P LII F Li L Shao L M He P J | 2012 | Bioresour Technd2012，126，： | 1 |
| 5 | Real-time microfluidic system for studying mammalian cells in 3D microenvironments 显示文摘 | LII J HSU W J PARSA H | 2008 | Anal Chem2008，80，10： | 1 |
| 6 | Predicting radiolog- ical panel opinions using a panel of machine learning classi- tiers显示文摘 | Zinovev D Raicu D S Furst J Lii S G A | 2009 | Algorithms2009，2，4： | 1 |
| 7 | Formation of BN films on carbon fibers by dip-coating显示文摘 | LII D F HUANG J L TSUI L J | 2002 | Surface & Coatings Technology2002，150，23： | 1 |
| 8 | Intensity modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: Does IMRT increase the integral dose to normal brain? 显示文摘 | Hermanto U Frija E K Lii M J | 2007 | Int J Radiat Oncol Biol Phys2007，67，4： | 1 |
| 9 | Effect of coupling agent on mechanical prop-erties of hollow carbon microsphere/phenolic resin syntactic foam显示文摘 | Zhang Liying Ma J | 2010 | Composites Science and Technology2010，70，8： | 1 |
| 10 | Investigation of the BN films prepared by low pressure chemical vapor deposition显示文摘 | Huang J L Pan C H Lii D F | 1999 | Surf Coat Technol1999，122，： | 1 |
| 11 | Hypoglycemic effect tff the total flavonoid fraction from Folium Eriobotryae 显示文摘 | Lii H Chcn J Li W L | 2009 | Phy- tomediclne2009，16，10： | 1 |
| 12 | Polychlorinated Biphenyls Contamination in Women with Breast Cancer 显示文摘 | Charlier C J Albert A I Zhang Liying | 2004 | Clinica Chimica Acta2004，347，12： | 1 |
| 13 | Isolation and characterization of most antimutagenic Maillard reaction products derived from xilose and lysine 显示文摘 | YEN G C CHAU C F LII D J | 1993 | Food Chemistry1993，41，： | 1 |
| 14 | Plasma etching of silicon in SF6 显示文摘 | Lii Y Jorne J | 1990 | Journal of the Electrochemical Society1990，137，11： | 1 |
| 15 | Change of granular and molecular structures of waxy maize and potato starches after treated in alcohols with or without hydrochloric acid显示文摘 | Lin J H Lii C Y Chang Y H | 2005 | Carbohydrate Polymers2005，59，： | 1 |
| 16 | Parameters identification and synchronization of chaotic systems based upon adaptive control 显示文摘 | Chen S Lii J | 2002 | Physics Letters A2002，299，4： | 1 |
| 17 | Ogunnaike nonlinear model predictive control of a simulated multivariable polymerization reactor using second-order Votterra models显示文摘 | Bryon R Maner Francis J Doyle lII Babatunde A | 1996 | Automati- ca1996，32，9： | 1 |
| 18 | Promoting Epithelium Regeneration for Esophageal Tissue Engineering through Basement Membrane Reconstitution 显示文摘 | Lii J J Chen L Zhu Y B | 2014 | ACS Applied Materials & Interfaces2014，6，49： | 1 |
| 19 | Acute evaluation of programmer-guided AV/PV and VV delay optimization comparing an IEGM method and echocardiogram for cardiac resynchronization ther- apy in heart failure patients and dual-chamber ICDs implants显示文摘 | Baker II JH McKenzie lII J Beau S | 2007 | J Cardiovasc Electrophysio12007，18，： | 1 |
| 20 | Contemporary crustal deformation around the southeast border- land of the Tibetan Plateau显示文摘 | Shen Z K Lii J N Wang M | 2005 | J Geophy Res2005，110，： | 1 |
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