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| 1 | Human amnion epithelial cells can be induced to differentiate into functional insulin-producing cells显示文摘胰腺的小岛移植证明了长期的胰岛素独立可以在受不了糖尿病 mellitus 类型 1 的病人被完成。然而,小岛织物的有限可获得性意味着对葡萄糖应答的生产胰岛素的房间的新来源被要求。这里,我们显示出那人的羊膜上皮的房间(HAEC ) 能被导致在 vitro 区分进功能的生产胰岛素的房间。在区别的正式就职以后, HAEC 表示了多重胰腺的 β-cell 基因,包括胰岛素,胰十二指肠 homeobox-1,配对的盒子基因 6, NK2 抄写因素相关的地点 2,小岛 1, glucokinase,和葡萄糖 transporter-2,和以响应另外的细胞外的刺激的一种调整葡萄糖的方式的释放 C 肽。进导致 streptozotocin 的糖尿病的 C57 老鼠的导致的 HAEC 的移植颠倒了多糖症,恢复了身体重量,并且维持了为 30 d 的 euglycemia。这些调查结果显示 HAEC 可以是为在类型 1 糖尿病的房间代替治疗的新来源。 | Yanan Hou | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 25 |
| 2 | Cancer stem-like cells can be isolated with drug selection in human ovarian cancer cell line SKOV3显示文摘为药抵抗的肿瘤的发展的一个新兴的模型利用作为癌症干细胞(CSC ) 或开始癌症的房间(用户信息控制系统) 知道的自我更新的恶意的祖先的一个水池。这研究的目的是从卵巢的癌症房间线 SKOV3 宣传如此的用户信息控制系统。SKOV3 范围房间在与表皮的生长因素补充的没有浆液的文化系统用 40.0 mol/l cisplatin 和 10.0 mol/l paclitaxel 被选择,基本成纤维细胞生长因素,白血病禁止的因素或标准包含浆液的系统。这些房间在药选择(cisplatin 和 paclitaxel ) 和没有浆液的文化系统下面形成了非支持者范围。选择范围房间对 cisplatin, paclitaxel, adriamycin,和 methotrexate 更抵抗。重要地,范围房间有自强的性质,与干细胞基因 Nanog, Oct4, sox2, nestin, ABCG2, CD133,和干细胞因素受体的高表示 CD117 (c 工具包) 。一致地,流动 cytometric 分析表明范围房间比区分的房间(33%) 有 CD133+/CD117+-positive 房间(71%) 的一个高得多的百分比。而且, SKOV3 范围房间是更多的 tumorigenic。而且, cDNA microarray 和随后的本体论的分析表明分类基因的一个大比例与 angiogenesis,细胞外的矩阵,调停 integrin 的发信号小径,房间粘附,和房间增长有关。从在这个文化系统下面的 SKOV3 房间线的 subpopulation 隔离出现一在为以他们的幸存,自强,和 chemoresistance 学习卵巢的 CSC,并且为开发明确地防碍卵巢的 CSC 的治疗学的药的 vitro 模型合适。 | Li Ma Dongmei Lai Te Liu Weiwei Cheng Lihe Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，9： | 18 |
| 3 | New evidence of deposition under cold climate for the Xieshuihe Formation of the Nanhua System in northwestern Hunan, China显示文摘Yangjiaping section is located in Hupingshan Town, Shimen County, Hunan Province. The section has been intensively studied since 1980. However, The paleoclimate during the deposition of the Xieshuihe Formation remains controversial. Based on chemical analysis of sedimentary clastic rocks of the unit, the resulting CIA (the chemical index of alteration) values of the Xieshuihe Formation are similar to those of the overlying Gucheng Formation (also called the Dongshanfeng Formation). It indicates that the sedimentary rocks of the Xieshuihe Formation and Gucheng Formation underwent the similar degrees of chemical weathering before deposition. Therefore, the Xieshnihe Formation was also likely to be deposited under a cold climatic condition, which probably belongs to a part of the record of glaciations. | FENGLianjun CHUXuelei ZHANGQirui ZHANGTonggang LIHe JIANGNeng | 2004 | Chinese Science Bulletin2004，49，13： | 16 |
| 4 | Transformation of human amniotic epithelial cells into neuron-like cells in the microenvironment of traumatic brain injury in vivo and in vitro显示文摘Survival and differentiation of transplanted cells is closely related to the local microenvironment.The present study cultured human amniotic epithelial cells(HAECs) in a simulated microenvironment in vitro comprising RPMI 1640 culture medium and the solution extracted from injured brain tissues.Some HAECs were round,triangular in form or irregularly shaped,with extended neuron-like processes;some of the processes were interconnected,representing neuron-like morphology and some HAECs were microtubule-associated protein 2-positive.HAECs survived for at least 4 weeks following transplantation into the center and edges of the trauma focus with traumatic brain injury,and were microtubule-associated protein 2-positive.Moreover,the motor function of rat hind limbs was significantly improved. | Yi Lu Guozhen Hui Zhiyuan Wu Tianjin Liu Xunhe Ji Lihe Guo | 2011 | Neural Regeneration Research2011，6，10： | 10 |
| 5 | Generation of 33 fs pulses directly from a Kerr-lens mode-locked Yb:CaYAlO4 laser显示文摘We experimentally demonstrated a diode-pumped Kerr-lens mode-locked femtosecond laser with a Yb:CaYAlO4 crystal as the gain medium. Pulse duration as short as 33 fs was obtained directly from the oscillator at a repetition rate of 115 MHz. The central wavelength was at 1059 nm with a spectral bandwidth of 49 nm. These are, to the bestof our knowledge, the shortest pulses generated from a Yb:CaYAlO4 oscillator. | Ziye Gao Jiangfeng Zhu Junli Wang Zhiyi Wei Xiaodong Xu Lihe Zheng Liangbi Su Jun Xu | 2015 | Photonics Research2015，3，6： | 8 |
| 6 | Rough set extensions in incomplete information systems显示文摘All eight possible extended rough set models in incomplete information systems are proposed.By analyzing existing extended models and technical meth-ods of rough set theory,the strategy of model extension is found to be suitable for processing incomplete information systems instead of filling possible values for missing attributes.After analyzing the definitions of existing extended models,a new general extended model is proposed.The new model is a generalization of indiscernibility relations,tolerance relations and non-symmetric similarity relations.Finally,suggestions for further study of rough set theory in incomplete informa-tion systems are put forward. | Guoyin WANG Lihe GUAN Feng HU | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，4： | 7 |
| 7 | Monoamine alterations and rotational asymmetry in a rat model of Parkinson's disease following lateral ventricle transplantation of human amniotic epithelial cells显示文摘BACKGROUND: Human amniotic epithelial cells (HAECs) can differentiate into neurons, astrocytes,and oligodendrocytes. They biologically secrete many active neurotrophins and have the capacity tometabolize dopamine enzymes. These features underlie a theoretical basis for the treatment ofParkinson's disease (PD).OBJECTIVE: To investigate the survival and differentiation of transplanted HAECs in the lateralventricle of PD model rats, and to explore its effect on circling behavior, as well as levels ofdopamine (DA), the metabolite homovanillic acid, dihydroxyphenyl acetic acid,5-hydroxyindoleacetic acid, and 5-hydroxytryptamine in the striatum.DESIGN, TIME AND SETTING: A randomized, controlled, animal study was performed at theInstitute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, ChineseAcademy of Sciences, and Shanghai Celstar Institute of Biotechnology from May 2007 to December2008.MATERIALS: HAECs were derived from the placental chorion following caesarean delivery at theShanghai International Maternal and Child Health Hospital. 6-hydroxydopamine (6-OHDA), andmouse anti-human Vimentin monoclonal antibody were purchased from Sigma, USA; mouseanti-human nestin and tyrosine hydroxylase (TH) monoclonal antibodies were purchased fromChemicon, USA.METHODS: A total of 114 healthy, adult, Sprague Dawley rats were randomly assigned to twogroups: PD model [n = 90, stereotactic microinjection of 2 μL 6-OHDA (3.5 μg/μL) into the striatum]and control (n = 24, no treatment). The 51 successful PD model rats were randomly divided into 3subgroups (n = 17): HAEC, PBS, and model. The HAEC and PBS groups were respectively injectedwith 10 μL PBS solution containing 1 x 105/mL HAECs or 10 μL PBS into the lateral ventricle. Themodel group was not treated.MAIN OUTCOME MEASURES: TH protein expression in the striatum was evaluated byimmunohistochemistry 5 weeks after HAEC transplantation. At 10 weeks, HAEC survival in thelateral ventricle was investigated by immunofluorescent staining; differentiation of HAECs in thelateral and third ventricles was examined by TH immunohistochemistry; concentrations of DA,homovanillic acid, dihydroxyphenyl acetic acid, 5-hydroxyindoleacetic acid, and 5-hydroxytryptaminein the striatum, as well as DA concentration in the cerebrospinal fluid, were measured withhigh-performance liquid chromatography-electrochemical detection. Circling behavior of PD modelrats was consecutively observed for 10 weeks following intraperitoneal injection of amphetamine 1week after successful model establishment.RESULTS: In the HAEC group, the number of TH-positive cells significantly increased in thestriatum, and circling behavior significantly decreased, compared with the PBS and model groups(P < 0.01). In addition, monoamine concentrations in the striatum, as well as DA concentrations inthe cerebrospinal fluid, significantly increased, compared with the PBS group (P < 0.05-0.01 ).Moreover, a large number of nestin-, vimentin-, and TH-positive cells were observed in the lateraland third ventricles following HAEC injection. CONCLUSION: HAECs survived for 10 weeks with no overgrowth following transplantation into thelateral ventricle of PD model rats. Moreover, the cells differentiated into dopaminergic neurons,which increased DA secretion. HAEC transplantation improved cycling behavior in PD model rats. | Shouru Xue Xinxin Yang Wanli Dong Guozhen Hui Lihe GUO | 2009 | Neural Regeneration Research2009，4，12： | 6 |
| 8 | Structural OH in mantle-derived clinopyroxene megacrysts from Nushan显示文摘Thirteen clinopyroxene megacrysts from Nushan Cenozoic basalts have been investigated by Fourier transform infrared spectrometer(FTIR). The results demonstrate that all samples contain trace amount of structural OH. Clinopyroxenes from Nushan show four groups of absorption bands, in which, 3 472-3 506 cm -1 is the major characteristic one. It is suggested that the position of major band is probably related to Al content: the position of major characteristic band for high_Al samples is around 3 470 cm -1 , whereas that for low_Al samples around 3 620 cm -1 . | Qunke Xia Daogong Chen Lihe Guo | 1998 | Chinese Science Bulletin1998，43，20： | 6 |
| 9 | Human amniotic epithelial cell feeder layers maintain mouse embryonic stem cell pluripotency via epigenetic regulation of the c-Myc promoter显示文摘老鼠胚胎的干细胞(转换字符) 在老鼠的 feeder 层上典型地是有教养的胚胎的成纤维细胞(MEF ) ,与白血病,禁止的因素(LIF ) 增加了处于一个无差别的状态维持他们。我们以前证明了人的羊膜的上皮的房间(hAECs ) 能被用作 feeder 房间维持老鼠转换字符 pluripotency,但是为这的机制是未知的。在现在的学习,我们发现那 CpG 5 c-Myc 基因仍然是的岛在在 hAECs 上有教养的老鼠转换字符的 hypomethylated。另外,在 c-Myc 基因倡导者 histone H3 的 acetylation 和 histone H3K4 的 trimethylation 铺平比在在 MEF 上有教养的 ES 房间的那些在在 hAECs 上有教养的 ES 房间是更高的。这些数据建议 hAECs 能经由 c-Myc 的 epigenetic 修正改变鼠标转换字符基因表示,提供为处于一个无差别的状态的转换字符的导致 hAEC 的维护的可能的机制。 | Te Liu Weiwei Cheng Tianjin Liu Lihe Guo Qin Huang Lizhen Jiang Xiling Du Fuhui Xu Zhixue Liu Dongmei Lai | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 6 |
| 10 | Amniotic fluid-derived stem cells mixed with platelet rich plasma for restoration of rat alveolar bone defect显示文摘从羊膜的液体孤立的干细胞作为房间治疗和织物工程的一个有希望的候选人被显示出。然而, maxillofacial 骨头织物工程的地里的羊膜的导出液体的干细胞(AFSC ) 的试验性、现出症状之前的潜的应用仍然是有限的。在这研究,老鼠 AFSC 成功地在 vitro 被收获并且描绘。老鼠 AFSC 显示出典型 fibroblastoid 形态学,稳定的增长活动和多区别潜力。Flow-cytometry 分析为象 CD34 和 CD45 那样的造血的标记证明这些房间为 CD29, CD44,和 CD90 是积极的,当否定时。与血小板富人一起的 AFSCs-premixed 的再生表演在牙槽的骨头缺点的恢复的血浆(PRP ) 胶化进一步用一只修改老鼠被调查颚的牙槽的缺点模型。微型电脑断层摄影术和组织学的检查在操作与控制组作比较以后在 4 和 8 个星期与 PRP 胶化显示出 AFSCs-premixed 的一个优异再生能力。而且,植入的 AFSC 能在缺点地点幸存并且直接参予骨头织物新生。一起拿,这些结果为牙槽的缺点恢复显示了基于 AFSCs 的牙槽的骨头织物工程策略的可行性。 | Minjiao Wang Hongliang Li Jiawen Si Jiewen Dai Jun Shi Xudong Wang Lihe Guo Guofang Shen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 5 |
| 11 | Groundwater Systems and Resources in the Ordos Basin,China显示文摘Ordos 盆是在西北的中国的大规模沉积的盆。到顶的从底部的 hydrostratigraphic 单位是 pre 寒武纪的变形岩石,更低的古生代的碳酸盐岩石,上面对中生代碎屑状的岩石和新生代存款古生代。全部的厚度直到 6000 m。三个地下水系统在 Ordos 盆是在场的,基于地质的设置,即石灰岩地区常见的地形地下水系统,白垩纪碎屑状的地下水系统和第四级的地下水系统。这份报纸系统地描述每个系统的地下水流动模式和对地下水资源的全面评价。 | HOU Guangcai LIANG Yongping SU Xiaosi ZHAO Zhenghong TAO Zhengping YIN Lihe YANG Yuncheng WANG Xiaoyong | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 5 |
| 12 | SEMA3A-mediated crosstalk between prostate cancer cells and tumor-associated macrophages promotes androgen deprivation therapy resistance显示文摘Androgen deprivation therapy(ADT)is an important treatment strategy that can be used to delay the progression of prostate cancer.However,after an initial response,which varies significantly among patients,the disease eventually progresses despite the low levels of testosterone in the systemic circulation.1 The mechanism underlying the progression of prostate cancer to castration-resistant prostate cancer(CRPC)is not yet clear,and further investigation is needed. | Fei Liu Chao Wang Hai Huang Yue Yang Lihe Dai Sujun Han Nianzeng Xing Shancheng Ren | 2021 | Cellular & Molecular Immunology2021，18，3： | 5 |
| 13 | Weighted Discriminative Sparse Coding for Image Classification显示文摘In the discriminative sparse coding,the reconstruction residual over each class-specific subdictionary can provide great discriminative and label information. In this paper, we propose a weighted discriminative sparse coding method by using the residual as the weight. For a test sample, we first compute its sparse code over each learnt sub-dictionary, and then use the reconstruction residual over each sub-dictionary to weight the corresponding sub-dictionary, thereby forming a weighted sample-specific structure dictionary, over which we compute a new sparse code for the test sample. This code carries more discriminative information about interclass difference. Our method yields a unique structure dictionary for each test sample, so that samples with the same class labels have more similar distributions of dictionary atom contributions. Experimental results demonstrate that the proposed method outperforms some state-of-the-art methods under the same learning conditions. | ZHANG Lihe ZHANG Kunyu | 2014 | Chinese Journal of Electronics2014，23，1： | 4 |
| 14 | Non-Oxidative Aromatization of CH4-C_3H_8 over La-Promoted Zn/HZSM-5 Catalysts显示文摘有在支持 La 的 Zn/HZSM-5 催化剂上的 C3H8 的混合 CH4 的非氧化的芳构化与空间速度 600 h 在 823 K 在一个改正床反应堆被学习(? 1 ) 并且 CH4/C3H8 (摩尔比)=5:1。丙烷变换和芳香的选择分别地在催化剂上直到 99% 和 60% ,当甲烷变换与 30% 的最高的变换有诱导期时。催化剂的结构和表面酸味被 XRD, NH3-TPD 和 TG-DTA 描绘。在这项活动和选择的反应和再生条件的影响也被调查。给词调音:芳构化;甲烷;丙烷;新生;镧;Zn; | Lihe Zheng Dong Xuan Jianjun Guo Hui Lou Xiaoming Zheng | 2006 | Journal of Natural Gas Chemistry2006，15，1： | 4 |
| 15 | Roles of pre-formed martensite in below-Ms bainite formation,microstructure,strain partitioning and impact absorption energies of low-carbon bainitic steel显示文摘The roles of pre-formed martensite(PM)in below-Ms bainite formation,microstructure,crystallography,strain partitioning and mechanical properties of a low-carbon bainitic steel were investigated using electron-backscattered diffraction,transmission electron microscopy,micro digital image correlation technique and mechanical tests.It is demonstrated that the pre-formation of martensite eliminates the incubation time for bainite transformation at various austempering temperatures below Ms,indicative of its acceleration effect at the early stage of transformation.This effect is mainly attributed to the surfaces or tips of the PM acting as the nuclei of subsequently-formed bainite,with initial bainite tending to form around the PM.However,the finishing time for below-Ms bainite transformation,especially at even lower temperatures,is retarded,owing to the dividing effect of PM on parent austenite grains,the decreasing effect of lowered isothermal temperature on the diffusion rate of carbon atoms and the strengthening effect of lowered isothermal temperature on supercooled austenite.PM and its adjacent bainitic laths have nearly the same crystallographic orientation and belong to the same block.The pre-formation of martensite largely refines the bainitic blocks/laths and retained austenite.The specimens with PM show relatively uniform strain partitioning among various phases,contrasting with the specimens without PM,for which strains are highly concentrated in the bainite region nearby fresh martensite/austenite(M/A)blocks or between adjacent M/A blocks.The impact absorption energies of the specimens with PM,when austempered at 30-60℃ below Ms,are more than twice higher than those of the specimens without PM,at no expense of tensile properties. | Lihe Qian Zhi Li Tongliang Wang Dongdong Li Fucheng Zhang Jiangying Meng | 2022 | Journal of Materials Science & Technology2022，，1： | 4 |
| 16 | Human amniotic epithelial cells express specific markers of nerve cells and migrate along the nerve fibers in the corpus callosum显示文摘Human amniotic epithelial cells were isolated from a piece of fresh amnion. Using immunocytochemical methods, we investigated the expression of neuronal phenotypes (microtubule-associated protein-2, glial fibrillary acidic protein and nestin) in human amniotic epithelial cells. The conditioned medium of human amniotic epithelial cells promoted the growth and proliferation of rat glial cells cultured in vitro, and this effect was dose-dependent. Human amniotic epithelial cells were further transplanted into the corpus striatum of healthy adult rats and the grafted cells could integrate with the host and migrate 1-2 mm along the nerve fibers in corpus callosum. Our experimental findings indicate that human amniotic epithelial cells may be a new kind of seed cells for use in neurograft. | Zhiyuan Wu Guozhen Hui Yi Lu Tianjin Liu Qin Huang Lihe Guo | 2012 | Neural Regeneration Research2012，7，1： | 3 |
| 17 | The Discovery of Magnesioferrite from Au (Fe, Cu) Magnesian Skarn Deposits and Study of the Magnesioferrite-Magnesiomagnetite Series显示文摘Magnesioferrite, a rare metasomatic mineral, was discovered for the first time in China from the Qinlou Au (Fe, Cu) magnesian skarn deposit, Sanpu, Huaibei, Auhui Province, and the Mulonggou Fe (Mo, Cu) magnesian skarn deposit, Luonan County, Shaanxi Province. In this paper, the geological setting, mineral associations, chemical composition, some physical properties, X-ray powder diffraction data and infrared spectroscopy of magnesioferrite and magnesiomagnetite are discussed. Magnesioferrite contains 17.66%-13.48% of MgO. Its main associated minerals are clinohumite, chondrodite, serpentine,, calcite and magnesiomagnetite. The density of magnesioferrite is 4.537-4.720, reflectances in percent are: 17.8-18.1, hardness is 838-900 kg/mm2, and the cell parameter a0 = 8.371-8.379 A. A systematic study of the magnesioferrite-magnesiomagnetite-magnetite series suggests that along with the increase of magnesioferrite molecules in the mineral, the density, reflectances and cell parameters decrease | ZHAO Yiming ZHANG Yinan BI Chengsi GUO Lihe | 1998 | Acta Geologica Sinica(English Edition)1998，72，4： | 3 |
| 18 | Investigation of T-cell receptor-y gene rearrangement in gastrointestinal lymphomas by PCR-SSCP analysis显示文摘AIM: To analyze the characterization of T-cell receptor-γ (TCR-γ) gene rearrangement in the gastrointestinal lymphomas and evaluate the value of PCR-SSCP analysis in gastrointestinal lymphomas investigation. METHODS: TCR-γ gene rearrangement segments of gastrointestinal lymphomas were cloned and sequenced. Single clone plasmid and mixed clone plsamids were subsequently submitted to PCR-SSCP analysis to investigate the relationship between the number of amplified clones and band patterns of the amplified products. The PCR products of TCR-γ gene rearrangement of 40 gastrointestinal lymphomas were electrophoresed on agarose gels and the positive cases on agarose gels were studied by SSCP analysis. RESULTS: The sequencing showed that TCR-γ gene rearrangement of the gastrointestinal lyrnphomas included functional gene and pseudogene with extensive variety in the junctional regions. In SSCP analysis, the number of the single-stranded bands was about two times of the number of amplified clones, and double-stranded band became broad with the increased number of the amplified clones. Thirteen of the 25 B-cell gastrointestinal lymphornas and 14 of the 15 gastrointestinal T-cell lymphomas were positive detected on agarose gel electrophoresis. Of the positive cases detected by SSCP analysis, 3 B-cell lyrnphomas and 13 T-cell lyrnphomas showed positive bands. The other cases showed only smears. The rearranged pattern included 13 monoallelic gene rearrangements and 3 biallelic or oligoclonal gene rearrangements. CONCLUSION: The pattern of TCR-γ gene rearrangement in gastrointestinal lymphomas are similar to that of the nodular lymphomas. PCR-SSCP analysis for TCR-γ gene rearrangement can be applied both for adjuvant diagnosis of gastrointestinal lymphomas and analysis of the gene rearrangement pattern. The ratio of TCR-γ gene rearrangements occurred in T-cell gastrointestinal lymphomas is significantly higher than that in B-cell gastrointestinal lymphomas. The gene rearrangement pattern involves monoallelic and biallelic (or oligoclonal) gene rearrangement. | Xi-QunHan LiHe Lan-YingShong Hui-YongJiang Mei-GangZhu TongZhao | 2004 | World Journal of Gastroenterology2004，10，7： | 3 |
| 19 | Microstructure and mechanical properties of a low carbon carbide-free bainitic steel co-alloyed with Al and Si显示文摘 | Lihe Qian Qian Zhou Fucheng Zhang Jiangying Meng Ming Zhang Yuan Tian | 2012 | Materials and Design2012，，： | 2 |
| 20 | FEM Modeling of Crack Propagation in a Model Multiphase Alloy显示文摘在这篇论文,几个广泛地应用的破裂标准数字地首先被检验, crack-tip-region J 积分标准被证实更适用在有弹性塑料的多相的材料预言破裂角度。然后,在理想化的树枝状的二阶段的 Al-7 百分比 Si 合金的裂缝繁殖用 anelastic 塑料的有限元素方法被建模。有裂缝扩展的裂缝生长驱动力的变化也被表明。裂缝路径被 alpha 阶段的存在显著地在裂缝尖端附近影响,这被发现,并且裂缝生长驱动力到处急速地变化。最后,在二阶段的模型合金的模仿的破裂路径与试验性地观察的破裂路径相比。 | Lihe QIAN Seishi NISHIDO Hiroyuki TODA Toshiro KOBA YASHI | 2006 | Journal of Materials Science & Technology2006，22，1： | 2 |
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