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| 1 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 2 | Fabrication of a nano-sized ZSM-5 zeolite with intercrystalline mesopores for conversion of methanol to gasoline显示文摘Carbon deposition during methanol to hydrocarbons leads to the quick deactivation of ZSM-5 catalyst and it is one of the major problems for this technology. Decreasing the crystal size or introducing mesopores into ZSM-5 zeolites can improve its diffusion property and decrease the coke formation. In this paper, nano-sized ZSM-5 zeolite with intercrystalline mesopores combining the mesoporous and nanosized structure was fabricated. For comparison, the mesoporous ZSM-5 and nano-sized ZSM-5 were also prepared. These catalyst samples were characterized by XRD, BET, NH3-TPD, TEM, Py-IR and TG techniques and used on the conversion of methanol to gasoline in a fixed-bed reactor at T = 405 °C, WHSV = 4.74 h-1and P = 1.0 MPa. It was found that the external surface area of the nano-sized ZSM-5 zeolite with intercrystalline mesopores reached 104 m2/g, larger than that of mesoporous ZSM-5(66 m2/g) and nanosized ZSM-5(76 m2/g). Catalytic lifetime of the nano-sized ZSM-5 zeolite with intercrystalline mesopores was 93 h, which was only longer than that of mesoporous ZSM-5(86 h), but shorter than that of nanosized ZSM-5(104 h). Strong acidity promoted the coke formation and thus decreased the catalytic lifetime of the nano-sized ZSM-5 zeolite with intercrystalline mesopores though it presented large external surface that could improve the diffusion property. The special zeolite catalyst was further dealuminated to decrease the strong acidity. After this, its coke formation rate was slowed and catalytic lifetime was prolonged to 106 h because of the large external surface area and decreased weak acidity. This special structural zeolite is a potential catalyst for methanol to gasoline reaction. | Tingjun Fu Jiangwei Chang Juan Shao Zhong Li | 2017 | Journal of Energy Chemistry2017，26，1： | 5 |
| 3 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis显示文摘Dear Editor,Ferroptosis is an iron-dependent,non-apoptotic form of regulated cell death characterized by an accumulation of lipid.derived reactive oxygen species(ROS).The small-molecule compo und erastin in duces ferroptosis via in hibiti ng the cystineglutamate antiporter system x_(c).which consists of two subunits,namely the light chain xCT and the heavy chain 4F2hc(encoded by the SLC7A11 and SLC3A2 genes,respectively).^(1-4) | Renhong Yan Enjun Xie Yaning Li Jin Li Yuanyuan Zhang Ximin Chi Xueping Hu Lei xu Tingjun Hou Brent R.Stockwell Junxia Min Qiang Zhou Fudi Wang | 2022 | Cell Research2022，32，7： | 4 |
| 4 | A zirconium modified Co/SiO_2 Fischer-Tropsch catalyst prepared by dielectric-barrier discharge plasma显示文摘Co/SiO2 and zirconium promoted Co/Zr/SiO2 catalysts were prepared using dielectric-barrier discharge(DBD) plasma instead of the conventional thermal calcination method.Fischer-Tropsch Synthesis(FTS) performances of the catalyst were evaluated in a fixed bed reactor.The results indicated that the catalyst treated by DBD plasma shows the higher FTS activity and yield of heavy hydrocarbons as compared with that treated by the conventional thermal calcination method.Increase in CO conversion was unnoticeable on the Co/SiO2 catalyst,but significant on the Co/Zr/SiO2 catalyst,both prepared by DBD plasma.On the other hand,heavy hydrocarbon selectivity and chain growth probability (a value) were enhanced on all the catalysts prepared by the DBD plasma.In order to study the effect of the DBD plasma treatment on the FTS performance,the catalysts were characterized by N2-physisorption,H2-temperature programed reduction(H2-TPR),H2-temperature-programmed desorption(H2-TPD) and oxygen titration,transmission electron microscope(TEM) and X-ray diffraction(XRD).It was proved that,compared with the traditional calcination method,DBD plasma not only could shorten the precursor decomposition time,but also could achieve better cobalt dispersion,smaller Co3O4 cluster size and more uniform cobalt distribution.However,cobalt reducibility was hindered to some extent in the Co/SiO2 catalyst prepared by DBD plasma,while the zirconium additive prevented significantly the decrease in cobalt reducibility and increased cobalt dispersion as well as the FTS performance. | Yunhui Jiang Tingjun Fu Jing Lü Zhenhua Li | 2013 | Journal of Energy Chemistry2013，22，3： | 4 |
| 5 | Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays显示文摘Androgen receptor(AR) is a ligand-activated transcription factor that plays a pivotal role in the development and progression of many severe diseases such as prostate cancer, muscle atrophy, and osteoporosis. Binding of ligands to AR triggers the conformational changes in AR that may affect the recruitment of coactivators and downstream response of AR signaling pathway.Therefore, AR ligands have great potential to treat these diseases. In this study, we searched for novel AR ligands by performing a docking-based virtual screening(VS) on the basis of the crystal structure of the AR ligand binding domain(LBD) in complex with its agonist. A total of 58 structurally diverse compounds were selected and subjected to LBD affinity assay, with five of them(HBP1-3, HBP1-17, HBP1-38, HBP1-51, and HBP1-58) exhibiting strong binding to AR-LBD. The IC50 values of HBP1-51 and HBP1-58 are 3.96 m M and 4.92 m M, respectively, which are even lower than that of enzalutamide(Enz, IC50= 13.87 m M), a marketed second-generation AR antagonist. Further bioactivity assays suggest that HBP1-51 is an AR agonist, whereas HBP1-58 is an AR antagonist. In addition, molecular dynamics(MD) simulations and principal components analysis(PCA) were carried out to reveal the binding principle of the newlyidentified AR ligands toward AR. Our modeling results indicate that the conformational changes of helix 12 induced by the bindings of antagonist and agonist are visibly different. In summary,the current study provides a highly efficient way to discover novel AR ligands, which could serve as the starting point for development of new therapeutics for AR-related diseases. | Wenfang Zhou Mojie Duan Weitao Fu Jinping Pang Qin Tang Huiyong Sun Lei Xu Shan Chang Dan Li Tingjun Hou | 2018 | Genomics, Proteomics & Bioinformatics2018，16，6： | 3 |
| 6 | Purification and characterization of phenoloxidase from Octopus ocellatus显示文摘从章鱼 ocellatus 的墨水囊的 Phenoloxidase (PO ) 被胶化过滤和离子交换层析净化,并且由把 L-dihydroxyphenylalanine (L-DOPA ) 用作特定的底层以它的生物化学、酶的性质描绘了。它从 O 被发现那 prophenoloxidase。当 153.8 kDa 的 heterodimeric 蛋白质,和 75.6 和 73.0 kDa 的二个子单元经常在 SDS 激活以后在准备被检测, ocellatus 被孤立。象 PO 一样活动显示出 7.0 的最佳的 pH, 40 的最佳的温度 ?????? | Tingjun Fan Mingyu Li Jing Wang Lingling Yang Rishan Cong | 2009 | Acta Biochimica et Biophysica Sinica2009，41，10： | 3 |
| 7 | Soil-Transmitted Helminthiasis--China,2018显示文摘What is already known about this topic?Soil-transmitted helminthiasis(STH)is distributed widely in China and a large number of the population is afflicted.However,trends of STH infections are decreasing.What is added by this report?The most recent data indicates that the overall prevalence of STH was 1.29% in 2018 in China,which was based on the national sentinel surveillance and demonstrates a continuous decline pattern.What are the implications for public health practice?Considering the current prevalence in China and various endemic statuses in different regions,precision control measures should be implemented for the control and elimination of STH in China. | Huihui Zhu Jilei Huang Changhai Zhou Tingjun Zhu Menbao Qian Mizhen Zhang Yingdan Chen Shizhu Li | 2020 | China CDC weekly2020，2，3： | 2 |
| 8 | A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer显示文摘Protein neddylation is catalyzed by a neddylation activating enzyme(NAE,E1),an E2 conjugating enzyme,and an E3 ligase.In various types of human cancers,the neddylation pathway is abnormally activated.Our previous study validated that the neddylation E2 UBE2F is a promising therapeutic target in lung cancer.Although the NAE inhibitor MLN4924/pevonedistat is currently under clinical investigation as an anti-cancer agent,there are no small molecules available that selectively target UBE2F.Here,we report,for the first time,the discovery,via structure-based virtual screen and chemical optimization,of such a small molecule,designated as HA-9104.HA-9104 binds to UBE2F,reduces its protein levels,and consequently inhibits cullin-5 neddylation.Blockage of cullin-5 neddylation inactivates cullin-RING ligase-5(CRL5)activity,leading to accumulation of the CRL5 substrate,NOXA,to induce apoptosis.Moreover,HA-9104 appears to form the DNA adduct via its 7-azaindole group to induce DNA damage and G2/M arrest.Biologically,HA-9104 effectively suppresses the growth and survival of lung cancer cells and confers radiosensitization in both in vitro cell culture and in vivo xenograft tumor models.In summary,we discovered a small molecule,designated HA-9104,that targets the UBE2F-CRL5 axis with anti-cancer activity alone or in combination with radiation. | Tiantian Xu Qisheng Ma Yanan Li Qing Yu Peichen Pan Yawen Zheng Zhijian Li Xiufang Xiong Tingjun Hou Bin Yu Hongmin Liu Yi Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 2 |
| 9 | Data Acquiring System Based on Vxi Bus显示文摘 | Li Tingjun | 2004 | 2nd International Conference on Active Media Technology2004，，5： | 1 |
| 10 | Design of Boot Loader in Embedded System 显示文摘 | Li Tingjun | | Proceedings of the0，6，： | 1 |
| 11 | Tonoplast H-ATPase in response to salt stress in populus euphratica cell suspensions显示文摘 | Tingjun Ma Qunlu Liu Zhuo Li | 2002 | Plant Science2002，163，： | 1 |
| 12 | Tonoplast H^+-ATPase in response to salt stress in Populus euphratica cell suspensions显示文摘 | Ma Tingjun Liu Qunlu Li Zhuo | 2002 | Plant Science2002，163，： | 1 |
| 13 | Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy显示文摘Protein neddylation is catalyzed by a three-enzyme cascade,namely an E1 NEDD8-activating enzyme(NAE),one of two E2 NEDD8 conjugation enzymes and one of several E3 NEDD8 ligases.The physiological substrates of neddylation are the family members of cullin,the scaffold component of cullin RING ligases(CRLs).Currently,a potent E1 inhibitor,MLN4924,also known as pevonedistat,is in several clinical trials for anti-cancer therapy.Here we report the discovery,through virtual screening and structural modifications,of a small molecule compound HA-1141 that directly binds to NAE in both in vitro and in vivo assays and effectively inhibits neddylation of cullins 1 e5.Surprisingly,unlike MLN4924,HA-1141 also triggers non-canonical endoplasmic reticulum(ER)stress and PKR-mediated terminal integrated stress response(ISR)to activate ATF4 at an early stage,and to inhibit protein synthesis and mTORC1 activity at a later stage,eventually leading to autophagy induction.Biologically,HA-1141 suppresses growth and survival of cultured lung cancer cells and tumor growth in in vivo xenograft lung cancer models at a well-tolerated dose.Taken together,our study has identified a small molecule compound with the dual activities of blocking neddylation and triggering ER stress,leading to growth suppression of cancer cells. | Yanan Li Chaorong Wang Tiantian Xu Peichen Pan Qing Yu Lei Xu Xiufang Xiong Tingjun Hou Sunliang Cui Yi Sun | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 14 | Influence of snow cover on the lower limit of permafrost in Altai Mountains显示文摘 | Zhang Tingjun Tong Boliang Li Shude | 1985 | Journal o Glaciology and Geocryology1985，7，1： | 1 |
| 15 | Design of computer management system 显示文摘 | Li Tingjun | 2004 | 3thlnternational Conferenceon Wayelet Analsis and Applications2004，，05： | 1 |
| 16 | Automatic Testing System for theWave-guide Measurement Line 显示文摘 | Zhao Yuanli Li Tingjun | 2003 | 5th International Symposium on Test and Measurement2003，，： | 1 |
| 17 | Design of Boot Loader in Embedded System显示文摘 | Li Tingjun | 2004 | Proceedings of the 6th International Progress Wavelet Analysis and Active Media Technology2004，，： | 1 |
| 18 | The System of Long-range Monitor and Measurement Based on Common Telephone显示文摘 | Tingjun Li | 2003 | 5th International Symposium on Test and Measurement2003，，6： | 1 |
| 19 | Automatic Measuring Mode of a Reciprocal Twoport Network显示文摘 | Tingjun Li | 2003 | 5th International Symposium on Test and Measurement2003，，6： | 1 |
| 20 | Data Acquiring System Based on VXIBus显示文摘 | Tingjun Li | 2004 | 2th International Conference on Active Media Technology2004，，5： | 1 |
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