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| 1 | Expression of IGF-Ⅱ,p53,p21 and HBxAg in precancerous events of hepatocarcinogenesis induced by AFBI and/or HBV in tree shrews显示文摘INTRODUCTIONIn order to study the relationship between oncogeneexpression and HCC generation,we observed theprecancerous hepatic GGT loci,IGF-Ⅱ,p53 andp21 expression during hepatocarcinogenesis of treeshrew induced by hepatitis B virus (HBV) and/oraflatoxin B1 (AFB1). | Qin LL Su JJ Li Y Yang C Ban KC Yian RQ | 2000 | World Journal of Gastroenterology2000，6，1： | 37 |
| 2 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 3 | Efficacies of β-L-D4A against Hepatitis B virus in 2.2.15 cells显示文摘AIM:To investigate the antiviral effect of beta-L-enantiomer of 2',3'-didehydro-2',3'-dideoxyadenosine (β-L-D4A) on 2.2.15 cells transfected with the hepatitis B virus (HBV) genome. METHODS:Lamivudine (3TC) as a positive control. Then, HBV DNA in treated 2.2.15 cells and the Hepatitis B surface antigen (HBsAg) in the culture supernatants were detected to determine the inhibitory effect of β-L-D4A. At the same time, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to detect the survival ratio of 2.2.15 cells. RESULTS:β-L-D4A has a dose-dependent inhibitory effect on HBV DNA replication;this effect was apparent when the concentration was above 1 mol/L. When β-L-D4A was at the highest concentration, 100 mol/L, the HBsAg inhibition ratio was above 50%. The Therapeutic index (TI) of β-L-D4A was above 2.1. CONCLUSION:β-L-D4A has a dose-dependent inhibitory effect on the replication of HBV DNA and the secretion of HBsAg at low toxicity. | Lin-Lin Gao, Xiao-Yan Wang, Ju-Sheng Lin, Ying-Hui Zhang, Yan Li, Institute of Liver Diseases, Tongji Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Author contributions:Gao LL and Wang XY contributed equally to this work Gao LL, Wang XY, Lin JS, Zhang YH, Li Y designed the research Gao LL and Wang XY performed the research Gao LL wrote the paper | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 4 | Genotypic variation in spatiotemporal distribution of canopy light interception in relation to yield formation in cotton显示文摘Background: Within-canopy interception of photosynthetically active radiation(PAR) impacts yield and other agronomic traits in cotton(Gossypium hirsutum L.). Field experiments were conducted to investigate the influence of 6 cotton varieties(they belong to 3 different plant types) on yield, yield distribution, light interception(LI), LI distribution and the relationship between yield formation and LI in Anyang, Henan, in 2014 and 2015.Result: The results showed that cotton cultivars with long branches(loose-type) intercepted more LI than did cultivars with short branches(compact-type), due to increased LI in the middle and upper canopy. Although loose-type varieties had greater LI, they did not yield significantly higher than compact-type varieties, due to decreased harvest index. Therefore, improving the harvest index by adjusting the source-to-sink relationship may further increase cotton yield for loose-type cotton. In addition, there was a positive relationship between reproductive organ biomass accumulation and canopy-accumulated LI, indicating that enhancing LI is important for yield improvement for each cultivar. Furthermore, yield distribution within the canopy was significantly linearly related to vertical LI distribution.Conclusion: Therefore, optimizing canopy structure of different plant type and subsequently optimizing LI distribution within the cotton canopy can effectively enhance the yield. | XING Fangfang HAN Yingchun FENG Lu ZHI Xiaoyu WANG Guoping YANG Beifang FAN Zhengyi LEI Yaping DU Wenli WANG Zhanbiao XIONG Shiwu LI Xiaofei Ll Yabing | 2018 | Journal of Cotton Research2018，1，3： | 3 |
| 5 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 6 | characterization by automated DNA Sequencing of mutation in the gene(rPOB) encoding the RNA polymerase subunit in rifampin-resistant Mycobacterium tuberculosis serains from New York City and Texas显示文摘 | Kapur V Li LL Iordanescu S | 1994 | Clin Microbiol1994，32，： | 1 |
| 7 | Genetic characteristics of human entero-virus 71 and coxsaekievirus A16 circulating from 1999 to 2004 inShenzhen,people s public of China显示文摘 | Li LL He YQ Yang H | 2005 | J Clin Microbiol2005，43，8： | 1 |
| 8 | The pivotal role ofc-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells 显示文摘 | Li DD Wang LL Deng R | 2009 | Oncogene2009，28，6： | 1 |
| 9 | Regulation of the Pseudomona aeruginosa quorum - sensing regulator VqsR 显示文摘 | Li LL Malone JE Iglewski BH | 2007 | J Bacteriol2007，189，： | 1 |
| 10 | Decreased expression of auto- phagy-related proteins in malignant epithelial ovarian cancer显示文摘 | Shen Y Li DD Wang LL | 2008 | Autophagy2008，4，8： | 1 |
| 11 | Involvement of tissue transglutaminase in endothelin-l-induced hypertrophy in cultured neonatal rat cardiomyocytes 显示文摘 | Li X Wei XL Meng LL | 2009 | Hypertension2009，54，7： | 1 |
| 12 | Human protein tyrosine phosphatase-like gene : expression profile, genomic structure, and mutation analysis in families with ARVD 显示文摘 | Li D Gonzalez O Bachinski LL | 2000 | Gene2000，256，12： | 1 |
| 13 | paclitaxel-indeced apoptosis in human gastric carcinoma cell lines显示文摘 | Chang YF Li LL Wu Cw etal | 1996 | cancer1996，77，1： | 1 |
| 14 | Do multiple renal arteries in the remnant kidney have a negative influence on kidney donors after kidney donation? 显示文摘 | Ma LL Li G Huang Y | 2011 | Nephrology (Carlton)2011，16，6： | 1 |
| 15 | Dietary supplementation with At-ractylodes Macrophala Koidz polysaccharides ameliorate metabolic status and improve immune function in early-weaned pigs显示文摘 | Li LL Yin FG Zhang B | 2011 | Livest Sci2011，142，1： | 1 |
| 16 | Inhibition of hydrogen sulfide gen- eration contributes to 1-methy-4-phenylpyridinium ion-induced neu- rotoxicity 显示文摘 | Tang XQ Fan LL Li Y J | 2011 | Neurotox Res2011，19，： | 1 |
| 17 | Characterization by auto- mated DNA sequencing of mutations in the gene(rpoB) enco- ding the RNA polymerase -subunit in rifampin-resistant Myco- bacterium tuberculosis strains from New York and Texas显示文摘 | Kapur V Li LL Iordanescu S | 1994 | J Clin Mierobiol1994，32，4： | 1 |
| 18 | Glucagon gene polymorphism modifies the effects of smoking and physical activity on risk of type 2 diabetes mellitus in Han Chinese 显示文摘 | Li LL Gao KP Zhao JZ | 2014 | Gene2014，534，2： | 1 |
| 19 | Characterization by automated DNA sequencing of mutations in the gene(rpoB)encoding the RNA polymerase β subunit in rifampin2resistant Mycobacterium tuberculosis strains from New York City and Texas显示文摘 | Kapur Li LL Iordanescu S | 1994 | J Clin Micmbiol1994，32，： | 1 |
| 20 | Adiponectin modulates carnitine palmitoyhransferase-1 through AMPK signaling cascade in rat cardiomyocytes 显示文摘 | Li L Wu LL Wang C | 2007 | Regul Peptide2007，139，： | 1 |
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