|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A显示文摘增加的证据建议 hsa-miR-126 (miR-126 ) 在房间衬里的非小的房间肺癌症(NSCLC ) 是下面调整的, miR-126 的恢复由指向特定的分子损害肿瘤房间增长,移植,侵略,和幸存。这里,我们第一次报导 miR-126 涉及调整 NSCLC 房间的反应到癌症化疗。在有 miR-126 的房间模仿的 transfected A549 或禁止者以后,我们发现 miR-126 的提高的水平显著地与减少的一半被联系 adriamycin ( ADM )和长春新碱的最大的禁止的集中, ADM 的增加的累积,脉管的 endothelial 生长因素 A ( VEGFA )和 multidrug 的下面规定联系抵抗的蛋白质 1 ( MRP1 ),并且 Akt 的 inactivation 发信号的小径。而且,提高了 miR-126 的表示压制了 A549 异种皮移植的生长并且禁止了 VEGFA 和 MRP1 的表示。miR-126 能高效地通过和 VEGFA 3-untranslated 区域的相互作用的下面调整 VEGFA 表示,而 VEGFA 的恢复能部分由 miR-126 稀释 MRP1 的抑制。然而, LY294002,表明小径的 PI3K/Akt 的一个禁止者,减少这效果,建议 miR-126 的那提高的表情通过发信号的 VEGF/PI3K/Akt/MRP1 的否定规定增加了 NSCLC 房间的敏感到 anticancer 代理人小径。 | Xiaolan Zhu Hao Li Lulu Long Lulu Hui Haining Chen Xuefeng Wang Huiling Shen Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 23 |
| 2 | Wood defect detection method with PCA feature fusion and compressed sensing显示文摘We used principal component analysis(PCA) and compressed sensing to detect wood defects from wood plate images. PCA makes it possible to reduce data redundancy and feature dimensions and compressed sensing, used as a classifier, improves identification accuracy. We extracted 25 features, including geometry and regional features, gray-scale texture features, and invariant moment features, from wood board images and then integrated them using PCA, and selected eight principal components to express defects. After the fusion process, we used the features to construct a data dictionary, and realized the classification of defects by computing the optimal solution of the data dictionary in l_1 norm using the least square method. We tested 50 Xylosma samples of live knots, dead knots, and cracks. The average detection time with PCA feature fusion and without were 0.2015 and 0.7125 ms,respectively. The original detection accuracy by SOM neural network was 87 %, but after compressed sensing, it was 92 %. | Yizhuo Zhang Chao Xu Chao Li Huiling Yu Jun Cao | 2015 | Journal of Forestry Research2015，26，3： | 17 |
| 3 | Emissions of polycyclic aromatic hydrocarbons from coking industries in China显示文摘这研究开始估计多不的芳香的烃的特征(哼) 从 coking 工业的排放,与在四典型焦炭植物进行的领域采样。为每选择植物,栈烟道气体样品在包括的进程期间是镇定的控告煤进炉(CC ) ,推焦炭(PC ) 和焦炭炉气体(CG ) 的燃烧。十六个个人在 US EPA 优先级表上哼被煤气的层析 / 团 spectrometry (GC/MS ) 分析。结果证明总数哼在烟道气体的集中从 45.776 ~ 414.874 g/m3 ,与为 CC (359.545 g/m3 ) 的最高的排放水平。集中哼在 CP1 (收费的邮票) 从 CC 过程射出从 CP3 和 CP4 (收费的顶) 是比那低的。Low-molecular-weight 哼(即,二 -- 到三戒指哼) 到总数的占优势的贡献者哼内容,和小睡, AcPy,流感, PhA,和蚂蚁被发现是最丰富的。为 CC (2.248 g/m3 ) 的全部的 BaPeq 集中比为 PC (1.838 g/m3 ) 的那些高, CG (1.082 g/m3 ) ,和 DbA 作为在从 coking 过程的排出物的 BaP 是到 carcinogenic 风险的一个重要贡献者。微粒哼比对总数的相应贡献哼的占了超过 20% 全部的 BaPeq 集中,它显著地高集体集中(5%) 。微粒并且气体哼当时,应该被考虑潜在的毒性风险哼污染在 coking 期间,过程被估计。吝啬的总数 -- 哼排放因素分别地是为 CC 和 PC 的 346.132 和 93.173 g/kg。 | Ling Mu Lin Peng Junji Cao Qiusheng He Fan Li Jianqiang Zhang Xiaofeng Liu Huiling Bai | 2013 | Particuology2013，11，1： | 17 |
| 4 | A Highly Pathogenic Strain of Porcine Deltacoronavirus Caused Watery Diarrhea in Newborn Piglets显示文摘Porcine deltacoronavirus(PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and China's Mainland. Here we isolated a strain of PDCoV, named CHN-GD-2016,from the intestinal content of a diseased newborn piglet with severe diarrhea in a pig farm in Guangdong, China. PDCoV CHN-GD-2016 could be identified by immunofluorescence with PDCoV specific rabbit antisera, and typical crown-shaped particles with spiky surface projections of this PDCoV were observed with electron microscopy. Genomic analysis showed that the PDCoV CHN-GD-2016 was closely related to other Chinese PDCoV strains, with the highest sequence similarity with the strain CHN/Tianjin/2016. Importantly, inoculation of newborn piglets with 1×10~5 TCID_(50) of CHN-GD-2016 by oral feeding successfully reproduced clear clinical symptoms, including vomiting, dehydration, and severe diarrhea in piglets. In addition, the virus RNA in rectal swabs from 1 to 7 days post inoculation was detected, macroscopic and microscopic lesions in small intestine were observed, and viral antigen was also detected in the small intestines with immunohistochemical staining. Collectively, the data show in this study confirms that PDCoV is present in Guangdong,China and is highly pathogenic in newborn piglets. | Zhichao Xu Huiling Zhong Qingfeng Zhou Yunping Du Li Chen Yun Zhang Chunyi Xue Yongchang Cao | 2018 | Virologica Sinica2018，33，2： | 16 |
| 5 | Assessment of coral bleaching using symbiotic zooxanthellae density and satellite remote sensing data in the Nansha Islands,South China Sea显示文摘Coral bleaching,characterized by a significant loss of symbiotic zooxanthellae,is the primary cause of mass coral mortality and reef degradation throughout the world.The characteristics,processes,and resistance of corals to bleaching varies significantly and is dependent on environmental conditions.We documented a mass coral bleaching event in June 2007 at the Meiji and Zhubi Reefs,Nansha Islands (NS),South China Sea using ecological surveys and measurement of coral zooxanthellae density and sea surface temperatures (SST).More than 35 species of corals (between 0-20 m in depth) were bleached.These bleached corals accounted for 15.6% of total corals in the investigated quadrats.The branching corals Pocillopora and Acropora were the most vulnerable species whereas the massive corals Porites and Favia were more tolerant of the high SSTs.Surprisingly,we found no evidence of bleaching in Agariciidae corals suggesting that this family is resistant to thermal stresses.The bleached corals had lost 72%-90% of their symbiotic zooxanthellae.Furthermore,corals that had no visual signs of bleaching had also lost 31%-53% of their zooxanthellae suggesting that most corals were experiencing the early stage of bleaching.The monthly mean SST during June 2007 was 30.8°C,the highest since 1998.Based on measurements of SST and the Hotspots and DHW data (NOAA),we conclude that it the extremely high SSTs triggered this coral bleaching event.Our results suggest that the previously accepted temperature thresholds used to predict coral bleaching based on satellite data are likely to underestimate the extent and intensity of coral bleaching,at least in the NS. | LI Shu,YU KeFu,CHEN TianRan,SHI Qi & ZHANG HuiLing CAS Key Laboratory of Marginal Sea Geology,South China Sea Institute of Oceanology,Chinese Academy of Sciences Guangzhou 510301,China | 2011 | Chinese Science Bulletin2011，56，10： | 15 |
| 6 | Non-Orthogonal Multiple Access(NOMA) for Future Downlink Radio Access of 5G显示文摘Multiple access(MA) technology is of most importance for 5G. Non-orthogonal multiple access(NOMA) utilizing power domain and advanced receiver has been considered as a promising candidate MA technology recently. In this paper, the NOMA concept is presented toward future enhancements of spectrum efficiency in lower frequency bands for downlink of 5G system. Key component technologies of NOMA are presented and discussed including multiuser transmission power allocation, scheduling algorithm, receiver design and combination of NOMA with multi-antenna technology. The performance gains of NOMA are evaluated by system-level simulations with very practical assumptions. Under multiple configurations and setups, the achievable system-level gains of NOMA are shown promising even when practical considerations were taken into account. | LI Anxin LAN Yang CHEN Xiaohang JIANG Huiling | 2015 | China Communications2015，12，S1： | 12 |
| 7 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 8 | Discovery of a male-biased mutant family and identification of a male-specific SCAR marker in gynogenetic gibel carp Carassius auratus gibelio显示文摘Gibel 鲤鱼(Carassius auratus gibelio ) 是一特别地有在自然产地的男性的次要的比率的 gynogenetic 种类,而是它的男起源和性决心机制是未知的。在这研究,一个偏导男性的变异的家庭从 gynogenetic gibel 鲤鱼被发现,并且一个男性特定的疤标记从变异的家庭被识别。正常精子发生被免疫荧光组织化学在男睾丸观察。将近相同的 AFLP 侧面在男性和女性之间被观察,但是一男性特定 86 bp AFLP 碎片被性水池 bulked segregant 分析并且单个屏蔽屏蔽。基于男性特定的 AFLP 碎片, 579 个 bp 序列的一个总数被染色体走克隆。随后,一个男性特定的疤标记被设计,并且男性特定的 DNA 碎片被证实稳定地被传给下一代并且一致地仅仅在男性检测了。 | Da Wang Huiling Mao Jinxia Peng Xiyin Li Li Zhou Jianfang Gui | 2009 | Progress in Natural Science:Materials International2009，19，11： | 11 |
| 9 | Photoreduction of CO_2 to methanol over Bi_2S_3/CdS photocatalyst under visible light irradiation显示文摘The Bi2S3,CdS and Bi2S3/CdS photocatalysts were prepared by direct reactions between their corresponding salt and thiourea in a hy- drothermal autoclave.The photocatalytic activities of these photocatalysts for reducing CO2 to CH3OH under visible light irradiation have been investigated.The results show that the photocatalytic activity and visible light response of Bi2S3 are higher than those of CdS.The Bi2S3 modification can enhance the photocatalytic activity and visible light response of CdS.The photocatalytic activity of Bi2S3/CdS hetero-junction photocatalyst was the highest and the highest yields of methanol was 613μmol/g when the weight proportion of Bi2S3 to CdS was 15%,which was about three times as large as that of CdS or two times of that of Bi2S3. | Xin Li Juntao Chen Huiling Li Jingtian Li Yitao Xu Yingju Liu Jiarong Zhou | 2011 | Journal of Natural Gas Chemistry2011，20，4： | 11 |
| 10 | Uniform blow-up profiles and boundary layer for a parabolic system with localized nonlinear reaction terms显示文摘This paper deals with the blow-up properties of the solution to a semilinear parabolic system with localized nonlinear reaction terms, subject to the null Dirichlet boundary condition. We first give sufficient conditions for that the classical solution blows up in the finite time, secondly give necessary conditions and a sufficient condition for that two components blow up simultaneously, and then obtain the uniform blow-up profiles in the interior. Finally we describe the asymptotic behavior of the blow-up solution in the boundary layer. | LI Huiling & WANG Mingxin Department of Mathematics, Southeast University, Nanjing 210018, China Department of Mathematics, Xuzhou Normal University, Xuzhou 221116, China | 2005 | Science China Mathematics2005，48，2： | 9 |
| 11 | Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis显示文摘最近的研究证明了 microRNA-21 (miR-21 ) 贡献肿瘤抵抗到化疗。有趣地,我们发现了 berberine 能在几根癌症房间线禁止 miR-21 表示。在这研究,我们调查了 berberine 是否能调制卵巢的癌症房间的敏感到 cisplatin 并且探索机制。被孵化, berberine 与 cisplatin 结合了的 cisplatin 抵抗的 SKOV3 房间独自比 cisplatin 有 signicantly 更低的幸存组和提高的导致 cisplatin 的 apoptosis。Berberine 能在卵巢的癌症禁止 miR-21 表示和功能,由它的目标 PDCD4 的改进出现在卵巢的癌症的重要肿瘤 suppressor。结果建议 berberine 能经由在卵巢的癌症房间调整 miR-21/PDCD4 轴调制 cisplatin 的敏感。 | Shiguo Liu Yue Fang Huiling Shen Wenlin Xu Hao Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 9 |
| 12 | Critical velocity in phosphorus exchange processes across the sediment-water interface显示文摘Sediments are ultimate sinks of nutrients in lakes that record the pollution history evolutionary processes, and anthropogenic activities of a lake. However, sediments are considered as inner sources of environmental factor changes such as the variation in hydrodynamic conditions because of the nutrients they release. How does this process happen? This study investigates a typical nutrient phosphorus(P) exchange among sediment, suspended particle matter(SPM), and water. Compared with numerical and experimental studies, this study confirms that the critical velocity that occurs at a lower flow rate state exists in the range of 7 to 15 cm/sec. Critical velocity below the critical flow rate promotes the migration of particulate phosphorus(PP) to the SPM. On the other hand, critical velocity above the critical flow rate promotes the release of PP in water. | Jun Wan Ze Wang Zhijie Li Huiling Duan HezhongYuan | 2013 | Journal of Environmental Sciences2013，25，10： | 9 |
| 13 | miR-25 modulates triacylglycerol and lipid accumulation in goat mammary epithelial cells by repressing PGC-1beta显示文摘Background: The goat(Caprahircus) is one of the most important livestock animals. Goat milk fat is an important component in the nutritional quality of goat milk. Growing evidence points to the critical roles of microRNAs(miRNAs) in lipid metabolism.Results: Using a highly sensitive method of S-poly(T) plus for miRNAs detection, we analyze the expression patterns of 715 miRNAs in goat mammary gland tissues at different stages of lactation. We observed that miR-25 expression had an inverse relationship with milk production. Overexpression of miR-25 significantly repressed triacylglycerol synthesis and lipid droplet accumulation. To explore the regulatory mechanism of miR-25 in milk lipid metabolism,we analyzed its putative target genes with bioinformatics analysis followed by 3′-UTR assays. Peroxisome proliferative activated receptor gamma coactivator 1 beta(PGC-1 beta), a key regulator of lipogenics was identified as a direct target of miR-25 with three specific sites within its 3′-UTR. In addition, miR-25 mimics in goat mammary epithelial cells reduced the expressions of genes involved in lipid metabolism.Conclusions: Taken together, our results show miR-25 is potentially involved in lipid metabolism and we reveal the function of the miR-25/PGC-1 beta regulatory axis during lactation. | Liuan Ma Huiling Qiu Zhi Chen Li Li Yan Zeng Jun Luo Deming Gou | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 9 |
| 14 | MULTI-PERIOD MEAN-VARIANCE PORTFOLIO SELECTION WITH MARKOV REGIME SWITCHING AND UNCERTAIN TIME-HORIZON显示文摘这份报纸调查一个多时期有政体切换和不明确的出口时间的吝啬变化的公事包选择。财产的回来都取决于被假定跟随分离时间的 Markov 链的随机的市场的状态。作者导出最佳的策略和模型的有效边疆在靠近形式。在存在文学的一些结果作为我们的结果的特殊情况被获得。 | Huiling WU Zhongfei LI | 2011 | Journal of Systems Science & Complexity2011，24，1： | 9 |
| 15 | A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice显示文摘Symbiotic microorganisms improve nutrient uptake by plants.To initiate mutualistic symbiosis with arbus-cular mycorrhizal(AM)fungi,plants perceive Myc factors,including lipochitooligosaccharides(LCOs)and short-chain chitooligosaccharides(CO4/CO5),secreted by AM fungi.However,the molecular mechanism of Myc factor perception remains elusive.In this study,we identified a heteromer of LysM receptor-like kinases consisting of OsMYR1/OsLYK2 and OsCERK1 that mediates the perception of AM fungi in rice.CO4 directly binds to OsMYR1,promoting the dimerization and phosphorylation of this receptor complex.Compared with control plants,Osmyr1 and Oscerk1 mutant rice plants are less sensitive to Myc factors and show decreased AM colonization.We engineered transgenic rice by expressing chimeric receptors that respectively replaced the ectodomains of OsMYR1 and OsCERK1 with those from the homologous Nod factor receptors MtNFP and MtL YK3 of Medicago truncatula.Transgenic plants displayed increased cal-cium oscillations in response to Nod factors compared with control rice.Our study provides significant mechanistic insights into AM symbiotic signal perception in rice.Expression of chimeric Nod/Myc recep-tors achieves a potentially important step toward generating cereals that host nitrogen-fixing bacteria. | Jiangman He Chi Zhang Huiling Dai Huan Liu Xiaowei Zhang Jun Yang Xi Chen Yayun Zhu Dapeng Wang Xiaofeng Qi Weichao Li Zhihui Wang Guoyong An Nan YU Zuhua He Yong-Fei Wang Youli Xiao Peng Zhang Ertao Wang | 2019 | Molecular Plant2019，12，12： | 9 |
| 16 | Photocatalytic reduction of carbon dioxide to methanol by Cu_2O/SiC nanocrystallite under visible light irradiation显示文摘The Cu2O/SiC photocatalyst was obtained from SiC nanoparticles (NPs) modified by Cu2O. Their photocatalytic activities for reducing CO2 to CH3OH under visible light irradiation have been investigated. The results indicated that besides a small quantity of 6H-SiC, SiC NPs mainly consisted of 3C-SiC. The band gaps of SiC and Cu2O were estimated to be about 1.95 and 2.23 eV from UV-Vis spectra, respectively. The Cu2O modification can enhance the photocatalytic performance of SiC NPs, and the largest yields of methanol on SiC, Cu2O and Cu2O/SiC photocatalysts under visible light irradiation were 153, 104 and 191μmol/g, respectively. | Huiling Li Yonggen Lei Ying Huang Yueping Fang Yuehua Xu Li Zhu Xin Li | 2011 | Journal of Natural Gas Chemistry2011，20，2： | 8 |
| 17 | Effect of Calcium Oxide Additive on the Performance of Iron Oxide Sorbent for High-Temperature Coal Gas Desulfurization显示文摘The effect of calcium oxide additive in iron oxide sorbent for hot gas desulfurization was investigated by XRD and TPR techniques.XRD characterization showed that CaO was highly dispersed after the calcination of sorbents.Calcium sulfate formed in the desulfurization was decomposed and regenerated to CaO by reacting with CO before the next sulfidation process.Calcium participated in every sulfidation/regeneration cycle and contributed to the enhancement of sulfur capacity.The TPR results showed that the reduction temperature of the sorbent increased with the increase of the content of calcium.Calcium played a role of retarding reduction.Therefore,the addition of calcium oxide additive will benefit the utilization of iron oxide sorbent in strongly reducing atmospheres. | Huiling Fan Kechang Xie Ju Shangguan Fang Shen Chunhu Li | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 7 |
| 18 | The research on the quantum tunneling characteristics and the radiation spectrum of the stationary axisymmetric black hole显示文摘At the event horizon and the cosmological horizon of the stationary axisymmetric Kerr-Newman black hole in the de Sitter space-time background, the tunneling rate of the charged particles is relevant with Bekenstein-Hawking entropy and the real radiation spectrum is not strictly pure thermal, but consistent with the underlying unitary theory in quantum mechanics. This is a feasible interpretation for the paradox of the black hole information loss. Taking the self-gravitation action, energy conservation, angular momentum conservation and charge conservation into account, the derived radiation spectrum is a correct amendment to the Hawking pure thermal spectrum. | YANG ShuZheng LI HuiLing JIANG QingQuan LIU MenQuan | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，2： | 7 |
| 19 | Plasma Nesfatin-1 concentration and its correlation with HPA axis in depression model rats显示文摘Objective To explore plasma Nesfatin-1 concentration and its correlation with hypothalamic pituitary adrenal(HPA) axis in depression model rats. Methods Twelve SD rats were randomly divided into normal control group(NCG) and depression model group(DMG). DMG received 5 consecutive weeks of 7 different chronic unpredictable mild stress(CUMS). The behavior of rats was evaluated by an open field test,sucrose preference test,and forced swimming test(FST). The concentration of plasma corticosterone and Nesfatin-1 were measured with an enzyme-linked immuno-sorbent assay(ELISA). Results Compared with NCG,DMG had a lower weight gain,lower index of sucrose preference and spent longer time being immobile in FST while all of these differences were statistically significant(P<0.05). The plasma concentrations of corticosterone and Nesfatin-1 were significantly higher in DMG than in theN CG(P<0.05). The plasma concentration of Nesfatin-1in DMG was positively correlated with the plasma corticosterone concentration. Conclusion CUMS could induce depression-like behavior in rats and increase the plasma concentration of Nesfatin-1 and corticosterone,while the HPA axis hyperactivity induced by CUMS may be associated with the increased concentration of Nesfatin-1. | WANG Gaohua WU Shengjuan WANG Huiling Wei Yanyan Gao Guoqing Li Jiangbo | 2016 | 国际精神病学杂志2016，43，3： | 6 |
| 20 | miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1显示文摘到化学疗法的代理人的 Multidrug 抵抗(MDR ) 是到在乳癌病人的成功的治疗的一个主要障碍。这研究的目的是调查 miR-137 是否涉及 MDR 的规定,并且在 MCF-7/ADM 房间的敏感上探索 miR-137 的机制。miR-137 是在 MCF-7/ADM 房间的 downregulated,并且它的表达式被发现相反地在乳癌房间与 Y 盒子有约束力的 protein-1 (YB-1 ) 和 P-glycoprotein (P-gp ) 层次相关。而且, YB-1 被酶记者试金和西方的污点分析作为 miR-137 的一个目标证实。而且, miR-137 的提高的表示减少了 YB-1 和 P-gp 的蛋白质表示层次, mimicking 在到 anticancer 代理人的 MCF-7/ADM 房间的敏感击倒的 YB-1 的效果,而 YB-1 的恢复减少了这效果。在结论,我们的结果证明 miR-137 被指向 YB-1 通过 P-gp 的调整在癌症涉及 MDR,建议 miR-137 可能是为阻止并且逆行在肿瘤房间的 MDR 的一个潜在的目标。 | Xiaolan Zhu Yuefeng Li Huiling Shen Hao Li Lulu Hui Wenlin Xu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员