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| 1 | Mesozoic contraction deformation in the Yanshan and northern Taihang mountains and its implications to the destruction of the North China Craton显示文摘Mesozoic contraction deformation in the Yanshan and Taihang mountains is characterized by basement-involved thrust tectonics,basement-cored buckling anticlines and ductile thrust and nappe tectonics.Most of these deformations are orientated west-east,west-northwest and northeast to north-northeast.The contraction deformations began in the Permian,continued through the Triassic and Jurassic and terminated in the Early Cretaceous,and constitute an important part of the destruction of the North China Craton.It is estimated,from balanced cross-section reconstructions,that the north-south shortening of the central part of the Yanshan belt before 135 Ma was around 38%.The initial crust thickness,pre-dating the major contraction deformation in late Paleozoic and early Mesozoic,was estimated to be around 35 km based on paleogeographic characteristics.Assuming that the inferred depth of ductile thrusting deformation,20-25 km,was the crust thickness involved in the contraction deformation,and also assuming that the N-S contraction deformation was accommodated by vertical crust thickening,the thickness of the crust after the contraction deformation was expected to be around 47-50 km.This was the approximate crust thickness required for the eclogitization of the lower crust for delamination.The gravity potential accumulated by the isostatic uplift of the thickened crust,together with the decrease in crustal strength caused by the coeval magmatisms associated with the contraction deformation,led to the subsequent extensional collapse of the middle and upper crust although the regional stress regime associated with the plate interactions remained constant.It is inferred that the Mesozoic contraction deformations in the Yanshan and Taihang mountains were not only a significant tectonic process contributing to the destruction of the craton in middle and upper crust but also stimulated delamination at a deep level and the extension of the shallow crust.In other words,both the suspected delamination of the lower crust and upper mantle and the well constrained extension deformations of the shallow crust in the eastern North China Craton during the late Mesozoic are a consequence of crust thickening due to previous contractions.Extensional deformations could be expected to occur independently in the shallow crust,and are not necessarily associated with or responding to delamination at a deep level. | ZHANG ChangHou LI ChengMing DENG HongLing LIU Yang LIU Lei WEI Bo LI HanBin LIU Zi | 2011 | Science China Earth Sciences2011，54，6： | 40 |
| 2 | Genesis of the Zhaokalong Fe-Cu Polymetallic Deposit at Yushu, China: Evidence from Ore Geochemistry and Fluid Inclusions显示文摘The ore types of the Zhaokalong Fe-Cu deposit are divided into two categories: sulfide-type and oxide-type. The sulfide-type ore include siderite ore, galena-sphalerite ore and chalcopyrite ore, whereas the oxide-type ore include magnetite ore and hematite ore. The ore textures and structures indicate that the Zhaokalong deposit is of the sedimentary-exhalative mineralization type. Geochemical analyses show that the two ore types have a high As, Sb, Mn, Co and Ni content. The REE patterns reveal an enrichment of the LREE compared to the HREE. Isotopic analysis of siderite ore reveal that the δ13CPDB ranges from 2.01 to 3.34 (‰) whereas the δ18O SMOW ranges from 6.96 to 18.95 (‰). The fluid inclusion microthermometry results indicate that homogenization temperatures of fluid inclusions in quartz range from 131 to 181℃, with salinity values of 1.06 to 8.04 wt% NaCl eq. The mineralizing fluid therefore belongs to the low temperature - low salinity system, with a mineralizing solution of a CO2-Ca2+(Na+, K+)-SO42-(F-, Cl-)-H2O system. The geochemical results and fluid inclusion data provide additional evidence that the Zhaokalong deposit is a sedex-type deposit that experienced two stages of mineralization. The sulfide mineralization probably occurred first, during the sedimentary exhalative process, as exhibited by the abundance of marine materials associated with the sulfide ores, indicating a higher temperature and relatively deoxidized oceanic depositional environment. After the main exhalative stage, hydrothermal activity was superimposed to the sulfide mineralization. The later stage oxide mineralization occurred in a low temperature and relatively oxidized environment, in which magmatic fluid circulation was dominant. | LI Huan XI Xiaoshuang WU Chengming Koichiro WATANABE | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 15 |
| 3 | Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer显示文摘Objective:The aim of this study was to investigate how the tumor immune microenvironment differs regarding tumor genomics,as well as its impact on prognoses and responses to immunotherapy in East Asian patients with non-small cell lung cancer(NSCLC).Methods:We performed an integrated analysis using publicly available data to identify associations between anti-programmed death 1(PD-1)/programmed death-ligand 1(PD-L1)immunotherapy efficacy and classic driver oncogene mutations in East Asian NSCLC patients.Four pooled and clinical cohort analyses were used to correlate driver oncogene mutation status and tumor microenvironment based on PD-L1 and CD8+tumor-infiltrating lymphocytes(TILs).Immune infiltrating patterns were also established for genomic NSCLC subgroups using the CIBERSORT algorithm.Results:Based on East Asian NSCLC patients,TIDE analyses revealed that for anti-PD-1/PD-L1 immunotherapy,epidermal growth factor receptor(EGFR)-mutant and anaplastic lymphoma kinase(ALK)-rearranged tumors yielded inferior responses;however,although Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors responded better,the difference was not statistically significant(EGFR:P=0.037;ALK:P<0.001;KRAS:P=0.701).Pooled and clinical cohort analyses demonstrated tumor immune microenvironment heterogeneities correlated with oncogenic patterns.The results showed remarkably higher PD-L1-and TIL-positive KRAS-mutant tumors,suggesting KRAS mutations may drive an inflammatory phenotype with adaptive immune resistance.However,the EGFR-mutant or ALK-rearranged groups showed a remarkably higher proportion of PD-L1-/TIL-tumors,suggesting an uninflamed phenotype with immunological ignorance.Notably,similar to triple wild-type NSCLC tumors,EGFR L858R-mutant tumors positively correlated with an inflammatory phenotype,suggesting responsiveness to anti-PD-1/PD-L1 immunotherapy(P<0.05).Furthermore,the CIBERSORT algorithm results revealed that EGFR-mutant and ALK-rearranged tumors were characterized by an enriched resting memory CD4+T cell population(P<0.001),as well as a lack of CD8+T cells(P<0.01),and activated memory CD4+T cells(P=0.001).Conclusions:Our study highlighted the complex relationships between immune heterogeneity and immunotherapeutic responses in East Asian NSCLC patients regarding oncogenic dependence. | Runsen Jin Chengming Liu Sufei Zheng Xinfeng Wang Xiaoli Feng Hecheng Li Nan Sun Jie He | 2020 | Cancer Biology & Medicine2020，17，3： | 10 |
| 4 | Towards full-spectrum photocatalysis: Achieving a Z-scheme between Ag2S and TiO2 by engineering energy band alignment with interfacial Ag显示文摘Z 计划是一条有希望的途径完成用途广泛的光催化。有有 1.0 eV 的乐队差距的另一个半导体的 TiO 2 的集成将对紫外的收获和在可见附近理想为光催化的红外线的光;然而,大多数 narrow-bandgap 半导体让与组成一个障碍到为 photocatalytic 氢生产形成 Z 计划的 TiO 2, 跨骑乐队结构排列。在这通讯,我们表明 Ag 2 是的 S 在哪儿的一个模型系统精力乐队分享一个接口,一个金属罐头克服的 narrow-bandgap 半导体换高速档这限制。制作设计,我们开发了一条唯一的途径综合 Ag 2 SAgTiO 2 混血儿结构。戏剧性地展出的获得的第三的混合结构在完整光谱的轻照明下面在 photocatalytic 氢生产提高了性能。这些活动比 Ag 2 SAgTiO 2 结构在下面 < 400 nm 并且 > 他们在任何轻照明下面的对应物的象那些一样的 400 nm 照耀调节。 | Yanrui Li Leilei Li Yunqi Gong Song Bai Huanxin Ju Chengming Wang Qian Xu Junfa Zhu Jun Jiang Yujie Xiong | 2015 | Nano Research2015，8，11： | 5 |
| 5 | Frequency-constrained Co-planning of Generation and Energy Storage with High-penetration Renewable Energy显示文摘Large-scale renewable energy integration decreases the system inertia and restricts frequency regulation. To maintain the frequency stability, allocating adequate frequency-support sources poses a critical challenge to planners. In this context, we propose a frequency-constrained coordination planning model of thermal units, wind farms, and battery energy storage systems (BESSs) to provide satisfactory frequency supports. Firstly, a modified multi-machine system frequency response (MSFR) model that accounts for the dynamic responses from both synchronous generators and grid-connected inverters is constructed with preset power-headroom. Secondly, the rate-of-change-of-frequency (ROCOF) and frequency response power are deduced to construct frequency constraints. A data-driven piecewise linearization (DDPWL) method based on hyperplane fitting and data classification is applied to linearize the highly nonlinear frequency response power. Thirdly, frequency constraints are inserted into our planning model, while the unit commitment based on the coordinated operation of the thermal-hydro-wind-BESS hybrid system is implemented. At last, the proposed model is applied to the IEEE RTS-79 test system. The results demonstrate the effectiveness of our co-planning model to keep the frequency stability. | Chengming Zhang Lu Liu Haozhong Cheng Dundun Liu Jianping Zhang Gang Li | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，4： | 4 |
| 6 | Corrosion resistance properties of AZ31 magnesium alloy after Ti ion implantation显示文摘Magnesium alloys have a wide range of applications in industry; however, their corrosion resistance, wear resistance, and hardness are rather poor, which limit their applications. Ti ion was implanted into the AZ31 magnesium alloy surface by metal vapor vacuum arc (MEVVA) implanter. This metal arc ion source has a broad beam and high current capabilities. The implantation energy was fixed at 45 keV and the dose was at 9 × 1017 cm?2. Through ion implantation, Ti ion implantation layer with approximately 900 nm in thickness was directly formed on the surface of AZ31 magnesium alloy, by which its surface property greatly improved. The chemical states of some typical elements of the ion implantation layer were analyzed by means of X-ray photoelectron spectroscopy (XPS), while the cross sectional morphology of the ion im-plantation layer and the phase structure were observed by means of scanning electron microscopy (SEM) and X-ray diffraction (XRD). The property of corrosion resistance of the Ti ion implanted layer was studied by the CS300P electrochemistry corrosion workstation in 3.5% NaCl solution. The results showed that the property of corrosion resistance was enhanced remarkably, while the corrosion velocity was obviously slowed down. | CHEN Fei ZHOU Hai CAI Suo LV Fanxiu LI Chengming | 2007 | Rare Metals2007，26，2： | 4 |
| 7 | A targeted sequencing approach to find novel pathogenic genes associated with sporadic aortic dissection显示文摘Aortic dissection(AD) is a heterogeneous genetic disease of the aorta with high mortality and poor prognosis. However, only few genetic causes of AD have been explored till date. After conducting a broad literature review focused on identifying potential pathogenic pathways, we designed a panel containing 152 AD-associated genes to conduct massively parallel targeted nextgeneration sequencing of 702 sporadic aortic dissection patients and 163 matched healthy controls. After validation by Sanger sequencing, we identified 21 definitely pathogenic and 635 likely pathogenic variants in 61.25%(430/702) of patients. In these patients, 34.88%(150/430) harbored more than one variant that was either definitely or likely to be pathogenic. Among the candidate genes, we identified 546 likely pathogenic variants in 47.72%(335/702) of patients. Importantly, we identified 94 lossof-function(LOF) variants in 45 genes in AD patients, but only five LOF variants in the controls(P=1.34×10^(-4)). With a burden test, we highlighted RNF213 as an important new gene for AD pathogenesis. We also performed transcriptome sequencing of human aorta tissues to evaluate the expression levels of these newly identified genes. Our study has compiled a comprehensive genetic map of sporadic AD in the Han Chinese population. We believe it will facilitate risk predicting and genetic diagnosis of this severe disease in the future. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2018 | Science China(Life Sciences)2018，61，12： | 4 |
| 8 | Attapulgite nanorods assisted surface engineering for separator to achieve high-performance lithium–sulfur batteries显示文摘Lithium-sulfur(Li-S)batteries have been recognized as one of the most promising candidates for nextgeneration portable electronic devices,owing to their extremely high energy density and low cost.However,the dissolution of lithium polysulfides(LiPSs)and consequent'shuttle effect'seriously hinder the practical deployment of Li-S batteries.Herein,multi-metal oxide nanorods named attapulgite are proposed as multifunctional ionic sieve to immobilize LiPSs and further promote the regulation of LiPSs.Attapulgite,consisting of Al,Mg,Fe,Si and O ions,possesses more polar sites to immobilize LiPSs in comparison with single metal oxides.In addition,the catalytic nature(Fe ions)of attapulgite avails the LiPSs conversion reaction,which is further confirmed by the linear sweep voltammetry and electrochemical impedance spectroscopy.Benefited from the synergistic effect of multi-metal oxide and conductive carbon,the Li-S battery with the modified separator delivers remarkable discharge capacities of 1059.4 mAh g-1 and 792.5 mAh g-1 for the first and 200th cycle at 0.5 C,respectively.The work presents an effective way to improve the electrochemical performance of Li-S batteries by employing attapulgite nanorods assisted separator surface engineering. | Wenhao Sun Xiaogang Sun Naseem Akhtar Chengming Li Weikun Wang Anbang Wang Kai Wang Yaqin Huang | 2020 | Journal of Energy Chemistry2020，29，9： | 4 |
| 9 | Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection显示文摘Aortic dissection(AD) is a devastating,heterogeneous condition of aorta.The homeostasis between collagens and matrix metalloproteases(MMPs)/tissue inhibitors of MMPs(TIMPs) system in the extracellular matrix plays an important role for structure and functions of aorta.However,our knowledge on association between variants of genes in this system and pathogenesis of AD is very limited.We analyzed all yet known coding human genes of collagens(45 genes),MMPs/TIMPs(27genes) in 702 sporadic AD patients and in 163 matched healthy controls,by using massively targeted next-generation and Sanger sequencing.To define the pathogenesis of potential disease-causing candidate genes,we performed transcriptome sequencing and pedigree co-segregation analysis in some genes and generated Col5a2 knockout rats.We identified 257 pathogenic or likely pathogenic variants which involved 88.89%(64/72) genes in collagens-MMPs/TIMPs system and accounted for 31.05%(218/702) sporadic AD patients.In them,84.86%patients(185/218) carried one variant,12.84%two variants and 2.30%more than two variants.Importantly,we identified 52 novel probably pathogenic loss-of-function(LOF) variants(20 nonsense,16 frameshift,14 splice sites,one stop-loss,one initiation codon) in 11.06%(50/452) AD patients,which were absent in 163controls(P=2.5×10^(-5)).Transcriptome sequencing revealed that identified variants induced dyshomeostasis in expression of collagens-TIMPs/MMPs systems.The Col5α2^(-/-) rats manifested growth retardation and aortic dysplasia.Our study provides a first comprehensive map of genetic alterations in collagens-MMPs/TIMPs system in sporadic AD patients and suggests that variants of these genes contribute largely to AD pathogenesis. | Zongzhe Li Chengming Zhou Lun Tan Peng Chen Yanyan Cao Chenze Li Xianqing Li Jiangtao Yan Hesong Zeng Dao-Wu Wang Dao-Wen Wang | 2017 | Science China(Life Sciences)2017，60，1： | 4 |
| 10 | Enhancing the catalytic efficiency of the Heck coupling reaction by forming 5 nm Pd octahedrons using kinetic control显示文摘异构的催化作用通过界面的反应的一个过程发生;因此,表面方面和尺寸控制能增加催化效率。八面的 Pd nanocrystals,围住由 { 111 } 方面,应该是理想的几何形状为哎呀联合反应;然而,综合是挑战性的有用存在帽子代理人技术的相对一致的尺寸分布的 5 nm Pd 八面体。这里,我们把钯用作一个模型系统调查原子增加的动力学怎么能精确用注射泵被控制。作为结果,我们的方法生产了象 5 nm 一样小的 Pd 八面体,它增加了催化效率哎呀当减少使用的催化剂的重量时,联合反应。 | Ran Long Di Wu Yaping Li Yu Bai Chengming Wang Li Song Yujie Xiong | 2015 | Nano Research2015，8，6： | 4 |
| 11 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 12 | Age, estimated glomerular filtration rate and ejection fraction score predicts contrast-induced acute kidney injury in patients with diabetes and chronic kidney disease: insight from the TRACK-D study显示文摘 | Li Jing Li Yi Wang Xiaozeng Yang Shuguang Gao Chuanyu Zhang Zheng Yang Chengming Jing Quanming Wang Shouli Ma Yingyan Wang Zulu Liang Yanchun Han Yaling | 2014 | Chinese Medical Journal2014，，12： | 3 |
| 13 | Geochemistry of the Batang Group in the Zhaokalong Area, Yushu, Qinghai: Implications for the Late Triassic Tectonism in the Northern Sanjiang Region, China显示文摘The Batang Group in the Zhaokalong area not only hosts an important Fe-Cu polymetallic deposit but also reveal important insights for the Late Triassic tectonism in the northern Sanjiang region. In order to delineate the tectonic setting and evolutionary process of the paleo arc-basin system, geochemical studies on the Batang Group strata have been carried out. The results suggest that andesite in the Zhaokalong area mainly belongs to the tholeiite series and is characterized by obvious fractionation of LREE and HREE, enrichment in LILE and depletion in HFSE, and a distinctly elevated δ^(34)SCDT average of 10.5‰. The sandstone is classified as lithic sandstone, which is also characterized by obvious fractionation of LREE and HREE, as well as weak negative Ce and Eu anomalies. The limestone displays positive Eu anomalies, with δ^(13)CPDB ranging from-1.3‰ to 4.4‰ and δ^(18) OSMOW ranging from 14.6‰ to 22.5‰. These results indicate that the andesite has a dual signature of both arc andesite and rift volcanic rocks, whereas the sandstone may be formed in an active continental margin, and the limestone could be deposited in a weak oxidizing shallow sea. The sandstone in the Zhaokalong area represents sedimentation in a platform slope facies, corresponding to the main stage of the Jinshajing oceanic basin subduction during the middle period of Late Triassic. The continental arc volcanic activity resulted from subsequent strengthened subduction, forming the andesite in the North Qiangtang backarc basin. Afterwards, the limestone was formed after the cessation of magmatic activity. The information gleaned from the Batang Group strata helped constrain the evolution of the paleo-Jomda island arc and Jinshajiang oceanic subduction in the Late Triassic. | LI Huan XI Xiaoshuang SUN Huashan KONG Hua WU Qianhong WU Chengming Jillian Aira S.GABO-RATIO | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 3 |
| 14 | The Sr, Nd isotopic composition of lamprophyres in Laowangzhai gold orefield, Yunnan Province显示文摘Lamprophyres are widely spread over the Laowangzhai gold orefield in northern Mt. Ailao structure zone, Yunnan Province. Lamprophyres in the orefield are temporally and spatially related to gold mineralization. Lamprophyres in the orefield have anomalous Sr and Nd isotopic compositions, e.g. the 87Sr/ 86Sr ratios (0.706 665-0.707 960, the 87Sr/ 86Sr ratio of sample YLW-44 is 0.709 041) are higher than the modern value of the original mantle (0.704 5), the 143Nd/ 144Nd ratios (0.512 463-0.512 551) are lower than the modern value of the original mantle (0.512 638), and the calculated values ε Sr>0 (28.1-63.7) and ε Nd<0 (-1.34--3.07). The results of investigation indicate that lamprophyres in the Laowangzhai gold orefield with anomalous Sr and Nd isotopic compositions would not be produced as a result of contamination of the primary magma with the isotopic features of MORB by the crust materials high 87Sr/ 86Sr ratios and low 143Nd/ 144Nd ratios in the processes of rising or in the magma chamber, but the result of metasomatism of source mantle. | Huang Zhilong Jin Zhisheng Zhu Chengming Wang Liankui Li Xianhua | 1998 | Chinese Science Bulletin1998，43，11： | 3 |
| 15 | Hydride vapor phase epitaxy for gallium nitride substrate显示文摘Due to the remarkable growth rate compared to another growth methods for gallium nitride(GaN)growth,hydride vapor phase epitaxy(HVPE)is now the only method for mass product GaN substrates.In this review,commercial HVPE systems and the GaN crystals grown by them are demonstrated.This article also illustrates some innovative attempts to develop homebuilt HVPE systems.Finally,the prospects for the further development of HVPE for GaN crystal growth in the future are also discussed. | Jun Hu Hongyuan Wei Shaoyan Yang Chengming Li Huijie Li Xianglin Liu Lianshan Wang Zhanguo Wang | 2019 | Journal of Semiconductors2019，40，10： | 3 |
| 16 | Etching approach to hybrid structures of PtPd nanocages and graphene for efficient oxygen reduction reaction catalysts显示文摘Cathodic oxygen reduction reaction (ORR) is a highly important electrochemical reaction in renewable-energy technologies. In general, the surface area, exposed facets and electrical conductivity of catalysts all play important roles in determining their electrocatalytic activities, while their performance durability can be improved by integration with supporting materials. In this work we have developed a method to synthesize hybrid structures between PtPd bimetallic nanocages and graphene by employing selective epitaxial growth of single-crystal Pt shells on Pd nanocubes supported on reduced graphene oxide (rGO), followed by Pd etching. The hollow nature, {100} surface facets and bimetallic composition of PtPd nanocages, together with the good conductivity and stability of graphene, enable high electrocatalytic performance in ORR. The obtained PtPd nanocage-rGO structures exhibit mass activity (0.534 A.m-1) and which are 4.4 times and 3.9 times greater than the specific activity (0.482 mA-cm-2) corresponding values for Pt/C. | Song Bai Chengming Wang Wenya Jiang Nana Du Jing Li Junteng Du Ran Long Zhengquan Li Yujie Xiong | 2015 | Nano Research2015，8，9： | 3 |
| 17 | Propofol blocks apoptosis and Bcl-2 and Bax expression induced by hypoxia-reoxygenation in primary cultures of rat hippocampal astrocytes显示文摘BACKGROUND:Cerebral hippocampal astrocytes are more sensitive to ischemic injury than neurons.Hypoxic-ischemic brain injury induces profound astrocyte apoptosis,and propofol may protect against astrocyte apoptosis. OBJECTIVE:To verify the protective effects of propofol against astrocyte apoptosis and to investigate anti-apoptotic Bcl-2 and pro-apoptotic Bax expression in primary cultures of rat hippocampal astrocytes exposed to hypoxia-reoxygenation for different periods of time following propofol treatment. DESIGN,TIME,AND SETTING:In vitro neural immunocytochemistry was performed at the Central Laboratory of Yunyang Medical College between September 2007 and March 2008. MATERIALS:A total of 30 Wistar rats,aged 1-3 days,with equal numbers of males and females, were included for isolation and culture of hippocampal astrocytes. METHODS:Hippocampal astrocytes were purified and cultured for 3 weeks and treated with four culture conditions:50μL Hank's solution(normal control);0.2 mL/L Intralipid;50μL Hank's solution for 10 minutes followed by hypoxic incubation for 4 hours and normoxic incubation for 12,24,36,48, 60 or 72 hours;propofol(250μmol/L final) for 10 minutes followed by hypoxic incubation for 4 hours and normoxic incubation for 12,24,36,48,60 and 72 hours. MAIN OUTCOME MEASURES:(1) Morphologic changes in hippocampal astrocytes.(2) Levels of astrocyte apoptosis and Bcl-2 and Bax expression. RESULTS:Hypoxia and reoxygenation increased apoptosis over time,with Bcl-2 expression peaking at 24 hours and decreasing gradually(P<0.01);Bax expression peaked at 72 hours(P< 0.01);the ratio of Bcl-2/Bax was 1.4,0.8,and 0.6,respectively,at 24,48 and 72 hours. Non-apoptotic astrocytes showed significant proliferation and swelling.Propofol treatment decreased apoptosis after hypoxia-reoxygenation(P<0.01),as well as Bcl-2 and Bax expression (P<0.05,P<0.01),with Bcl-2/Bax ratios of 1.6-1.8.Propofol treatment also blocked astrocyte proliferation and swelling.No apoptotic cells or Bcl-2/Bax expression was detected in astrocytes cultured in Hank's or Intralipid solution. CONCLUSION:Propofol protects astrocytes against injury caused by hypoxia and reoxygenation via a mechanism that involves maintaining high ratios of Bcl-2/Bax. | Qing Li Juying Liu Long Zhou Chengming Qin | 2009 | Neural Regeneration Research2009，4，7： | 3 |
| 18 | Sleeping site use of the white-headed langur Trachypithecus leucocephalus: The role of predation risk, territorial defense, and proximity to feeding sites显示文摘 | Dayong LI Qihai ZHOU Xiaoping TANG Henglian HUANG Chengming HUANG | 2011 | Current Zoology2011，57，3： | 3 |
| 19 | Predicting future dynamics from short-term time series using an Anticipated Learning Machine显示文摘Predicting time series has significant practical applications over different disciplines.Here,we propose an Anticipated Learning Machine(ALM)to achieve precise future-state predictions based on short-term but high-dimensional data.From non-linear dynamical systems theory,we show that ALM can transform recent correlation/spatial information of high-dimensional variables into future dynamical/temporal information of any target variable,thereby overcoming the small-sample problem and achieving multistep-ahead predictions.Since the training samples generated from high-dimensional data also include information of the unknown future values of the target variable,it is called anticipated learning.Extensive experiments on real-world data demonstrate significantly superior performances of ALM over all of the existing 12 methods.In contrast to traditional statistics-based machine learning,ALM is based on non-linear dynamics,thus opening a new way for dynamics-based machine learning. | Chuan Chen Rui Li Lin Shu Zhiyu He Jining Wang Chengming Zhang Huanfei Ma Kazuyuki Aihara Luonan Chen | 2020 | National Science Review2020，7，6： | 3 |
| 20 | IMPROVING 9-INTERSECTION MODEL BY REPLACING THE COMPLEMENT WITH VORONOI REGION显示文摘intersection model is the most popular framework used for formalizing the spatial relations between two spatial objects A and B. It transforms the topological relation- ships between two simple spatial Objects A and B into point-set topology problem in terms of the intersections of A’s boundary ( A), interior (A0) and exterior (A - ) with B’s bound- ary ( B), interior (B0) and exterior (B - ). It is shown in this paper that there exist some limitations of the original 9-intersection model due to its definition of an object’s exterior as its complement,and it is difficult to distinguish different disjoint relations and relations be- tween complex objects with holes, difficult or even impossible to compute the intersections with the two object’s complements ( A B -, A0 B -, A - B, A - B0 and A - B - )since the complements are infinitive. The authors suggest to re-define the exterior of spa- tial object by replacing the complement with its Voronoi region. A new Voronoi-based 9-in- tersection (VNI) is proposed and used for formalizing topological relations between spatial objects. By improving the 9-interscetion model, it is now possible to distinguish disjoint rela- tions and to deal with objects with holes. Also it is possible to compute the exterior-based in- tersections and manipulate spatial relations with the VNI. | CHEN Jun LI Chengming LI Zhilin Gold C M | 2000 | Geo-Spatial Information Science2000，3，1： | 2 |
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