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| 1 | Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis显示文摘OBJECTIVE: To investigate the association of E-selectin S128R polymorphisms with ischemic stroke. DATA SOURCES: A computer-based online search was conducted in PubMed, Elsevier, Ovid Database, the China National Knowledge Infrastructure, and Wanfang Database between January 1998 and December 2010. STUDY SELECTION: Case-controlled studies addressing the association of the E-selectin polymorphism and ischemic stroke were included in this review. The genotype distribution complied with the Hardy-Weinberg genetic equilibrium. The included reports were evaluated by two authors for strict quality screening. Meta-analysis software, REVMAN 5.1, was used to investigate heterogeneity, pooled odds ratio (OR) and 95% confidence interval (CI) in individual studies. MAIN OUTCOME MEASURES: Genotype and allele distributions at the E-selectin S128R site. RESULTS: Six case-controlled studies were included after screening and application of inclusion and exclusion criteria. There was no heterogeneity in the genotype and allele frequencies, and no publication bias was found. Meta-analysis of the pooled data showed that the OR value of the (AC+CC)/AA genotype was 1.93 (95% CI: 1.55-2.41, Z = 5.80, P < 0.000 01), and the OR for the C/A allele was 1.80 (95% CI: 1.47-2.22, Z = 5.59, P < 0.000 01) in the ischemic stroke group, compared with control group. Results of pooled data in Chinese subjects showed that the OR value of (AC+CC)/AA was 2.36 (95% CI: 1.68-3.31, Z = 4.99, P < 0.000 01), and the OR value of the C/A allele was 2.25 (95% CI: 1.63-3.12, Z = 4.89, P < 0.000 01). CONCLUSION: Polymorphism of E-selectin S128R was significantly associated with susceptibility to ischemic stroke; the AC and CC genotypes as well as the C allele may be factors associated with susceptibility to ischemic stroke. | Qingli Sun Yu Fu Aping Sun Yanhong Shou Mei Zheng Xiaogang Li Dongsheng Fan | 2011 | Neural Regeneration Research2011，6，22： | 46 |
| 2 | Slower cycling of nestin-positive cells in neurosphere culture显示文摘 | Ma BF Liu XM Xie XM Zhang AX Zhang JQ Yu WH Zhang XM Li SN Lahn BT Xiang AP | 2006 | 中国生物学文摘2006，20，5： | 4 |
| 3 | Salivary Actinomyees naeslundii Genospecies and Lactobacillus casei Levels Predict Pregnancy Outcomes显示文摘 | Dasanayake AP Li Y Wiener H | 2005 | J Periodontol2005，76，2： | 1 |
| 4 | Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease显示文摘 | Bolger AP Sharma R Li W | 2002 | Circulation2002，106，1： | 1 |
| 5 | Quantitative reverse transcriptase/PCR assay for the measurement of induction in cultured hepatocytes 显示文摘 | Mattes WB Li AP | 1997 | Chem Biol Interact1997，107，1： | 1 |
| 6 | Polyol pathway and osmoregulation in JS1 Schwann cells grown in hyperglycemic and hyperosmotic conditions 显示文摘 | Mizisin AP Li L Perello M | 1996 | Am J Physiol1996，270，39： | 1 |
| 7 | Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension:comparison between urban and rural communities in China显示文摘 | Avolio AP Deng FQ Li WQ | 1985 | Circulation1985，71，2： | 1 |
| 8 | Polymyxin B for the treatment of multidrug-resistant pathogens~a critical review显示文摘 | Zavascki AP Goldani LZ Li J | 2008 | J Antimierob Chemother2008，60，6： | 1 |
| 9 | Polymyxin B for the treat?ment of multidrug-resistant pathogens: a critical review显示文摘 | Zavascki AP Goldani L2 Li J | 2007 | J An?timicrob Chemother2007，60，6： | 1 |
| 10 | The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair显示文摘 | Li B Castano AP Hudson TE | 2010 | FASEB J2010，24，12： | 1 |
| 11 | Shoulder function after thoracic surgery 显示文摘 | Li WW Lee TW Yim AP | 2004 | Thorac Surg Clin2004，14，3： | 1 |
| 12 | Semiconductor nanorod liquid crystals and their assembly on a substrate显示文摘 | LI LS ALIVISATOS AP | | Adv Mater0，15，5： | 1 |
| 13 | Generation of breast cancer stem cells through epithelial-mesenchymal transition显示文摘 | Morel AP Lièvre M Thomas C | | 0，，08： | 1 |
| 14 | Accurate prediction of human drug toxicity:a major challenge in drug development显示文摘 | Li AP | 2004 | Chem Biol Interact2004，150，1： | 1 |
| 15 | Accurate prediction of human drug toxicity : a major challenge in drug development显示文摘 | LI AP | 2004 | Chem Biol interact2004，150，1： | 1 |
| 16 | Generation of breast cancer stem cells through epithelial-mesenchymal transition显示文摘 | Morel AP Li è vre M Thomas C | 2008 | PLoS One2008，3，8： | 1 |
| 17 | Elevated circulating levels of in- flammatory eytokines and bacterial endotoxin in adults with congenital heart disease显示文摘 | Sharma R Bolger AP Li W | 2003 | Am J Cardiol2003，92，2： | 1 |
| 18 | A sensitive non-radioactive northern blot method to detect small RNAs显示文摘 | Kim SW Li Z Moore PS Monaghan AP Chang Y Nichols M John B | | 0，，07： | 1 |
| 19 | A comprehensive approach for drug safety assessment显示文摘 | LI AP | 2004 | Chem Biol Interact2004，150，1： | 1 |
| 20 | Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China显示文摘 | Avolio AP Deng Fa-quan Li Wei-qiang | 1985 | Circulation1985，71，2： | 1 |
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