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| 1 | 抑制平滑肌的张力收缩:一种治疗勃起功能障碍的新途径显示文摘阴茎海绵体血管的收缩及张力的维持是由钙敏感的RhoA/Rho激酶信号传导途径介导的。以Y 2 76 32抑制海绵体平滑肌细胞的Rho激酶信号系统可促进阴茎勃起 ,表现为海绵体内压 (ICP)明显升高 ,而平均动脉压 (MAP)变化不显著。为什么在血管收缩信号很强的情况下性刺激仍能引发阴茎勃起反应 ?我们设想体内一氧化氮 (NO)能直接抑制RhoA/Rho激酶途径的活性 ,减少血管张力 ,促使血管舒张 ,勃起发生 ,使用Y 2 76 32可以恢复性腺功能低下和高血压病动物ED模型的阴茎勃起功能 ,这表明抑制Rho激酶活性药物具有临床应用的前景。此外 ,我们的结果显示阴茎表面使用Rho激酶抑制剂可能为ED治疗的有效方法之一。 | 戴玉田 Thomas M MILLS Ronald W LEWIS RClinton WEBB | 2002 | 中华男科学杂志2002，8，6： | 8 |
| 2 | Adaptive fuzzy logic control of discrete-time dynamical systems 显示文摘 | Jagannathan A Vandegrift M W Lewis F L | 2000 | Automatica2000，36，2： | 2 |
| 3 | Variation in trophie shift for stable isotope ratios of carbon, nitrogen, and sulfur显示文摘 | MCCUTCHAN JR J H LEWIS JR W M KENDALL C | 2003 | Oikos2003，102，2： | 1 |
| 4 | Vertical nitrite fluxes in the oligotrophic ocean显示文摘 | Lewis M R Harrison W G Oakey N S | 1986 | Science1986，234，： | 1 |
| 5 | Rationale for control of anthropogenic nitrogen and phosphorus to reduce eutrophication of inland waters 显示文摘 | LEWIS J W M WURTSBAUGH W A PAERL H W | 2011 | Science and Technology2011，45，10： | 1 |
| 6 | Prediction of mammalian microRNA targets显示文摘 | Lewis B P Shih I H Jones-Rhoades M W | 2003 | Cell2003，115，7： | 1 |
| 7 | Cellular responses to increasing Cd concentrations in the freshwater crab, Potamonautes warreni, harbouring microbial gill infestations 显示文摘 | SCHUWERACK P M LEWIS J W | 2003 | Cell Tissue Research2003，313，3： | 1 |
| 8 | Prediction of mammalian microRNA targets显示文摘 | Lewis B P Shih I H Jones-Rhoades M W | 2003 | Cell2003，115，： | 1 |
| 9 | Exploitation-exploration tensions and organizational ambidexterity: Managing paradoxes of innovation 显示文摘 | Andriopoulos C Lewis M W | 2009 | Organization Science2009，20，4： | 1 |
| 10 | Evaluation of high power ultrasound porous cleaning efficacy in American oak wine barrels using X-ray tomography显示文摘 | Porter G W Lewis A Barnes M | 2011 | Innovative Food Science and Emerging Technologies2011，，4： | 1 |
| 11 | Innovation- supportive culture : The impact of organizational values on process innovation 显示文摘 | KHAZANCHI S LEWIS M W BOYER K K | 2007 | Journal of Operations Management2007，，25： | 1 |
| 12 | Lumbar interbody fusion using the Brantigan I/F cage for posterior lumbar interbody fusion and variable pedicle screw placement system:two-year results from a Food and Drug Administration investigational device exemption clinical trial显示文摘 | Brantigan J W Steffce A D Lewis M L | 2000 | Spine2000，25，12： | 1 |
| 13 | Highly efficient separation of actinides from lanthanides by a phenanthroline derived his triazine ligand 显示文摘 | LEWIS F W HARWOOD L M HUDSON M J | 2011 | Journal of the American Chemical Society2011，133，13： | 1 |
| 14 | Innovation-support- ive culture: the impact of organizational values on process innovation 显示文摘 | Khazanchi S Lewis M W Boyer K K | 2007 | Journal of Operations Management2007，25，4： | 1 |
| 15 | Nitrogen ebullition in a Colorado plains river显示文摘 | Higgins T M McCutchan Jr J H Lewis Jr W M | 2008 | Biogeochemistry2008，89，： | 1 |
| 16 | Angiogenic and lym- phangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF-family gene expression 显示文摘 | Choi W W Lewis M M Lawson D | 2005 | ModPathol2005，18，1： | 1 |
| 17 | The effects of the phytoestrogen genistein on the postnatal development of the rat 显示文摘 | Lewis R W Brooks N Milburn G M | 2003 | Toxicol Sci2003，71，1： | 1 |
| 18 | Localised Oxidation Defects in TiA1N/CrN Superlattice Structured Hard Coatings Grown by Cathodic Arc/Unbalanced Magnetron Deposition on Various Substrate Materials显示文摘 | Lembke M Lewis D Munz W | 2000 | Surf Coat Technol2000，125，： | 1 |
| 19 | Structure of fish as semblages along environmental gradients in floodplain lakes of the Orinoco River显示文摘 | RODRiGUEZ M A LEWIS J R W M | 1997 | Ecological Monographs1997，67，10： | 1 |
| 20 | New production in the central equatorial Pacific 显示文摘 | PENA M A HARRISON W G LEWIS M R | 1992 | Mar Ecol Prog Ser1992，80，： | 1 |
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