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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans显示文摘AIM To determine whether and to what extent the gut microbiome is involved in regulating racial disparity in colorectal cancer(CRC). METHODS All patients were recruited and experiments were performed in accordance with the relevant guidelines and regulations by the Institutional Review Boards (IRB), committees of the John D. Dingell VAMC and Wayne State University guidelines. African American (AA) and Caucasian American (CA) patients were scheduled for an outpatient screening for colonoscopy, and no active malignancy volunteer patients were doubly consented, initially by the gastroenterologist and later by the study coordinator, for participation in the study. The gut microbial communities in colonic effluents from AAs and CAs were examined using 16 sRNA profiling, and bacterial identifications were validated by performing SYBR-based Real Time PCR. For metagenomic analysis to characterize the microbial communities, multiple software/tools were used, including Metastats and R statistical software.RESULTS It is generally accepted that the incidence and mortality of CRC is higher in AAs than in CAs. However, the reason for this disparity is not well understood. We hypothesize that the gut microbiome plays a role in regulating this disparity. Indeed, we found significant differences in species richness and diversity between AAs and CAs. Bacteroidetes was more abundant in AAs than in CAs. In particular, the pro-inflammatory bacteria Fusobacterium nucleatum and Enterobacter species were significantly higher in AAs, whereas probiotic Akkermansia muciniphila and Bifidobacterium were higher in CAs. The polyphyletic Clostridia class showed a divergent pattern, with Clostridium XI elevated in AAs, and Clostridium IV, known for its beneficial function, higher in CAs. Lastly, the AA group had decreased microbial diversity overall in comparison to the CA group. In summary, there were significant differences in pro-inflammatory bacteria and microbial diversity between AA and CA, which may help explain the CRC disparity between groups.CONCLUSION Our current investigation, for the first time, demonstrates microbial dysbiosis between AAs and CAs, which could contribute to the racial disparity of CRC. | Lulu Farhana Fadi Antaki Farhan Murshed Hamidah Mahmud Stephanie L Judd Pratima Nangia-Makker Edi Levi Yingjie Yu Adhip PN Majumdar | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 3 |
| 3 | Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation显示文摘Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stom-ach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distension with CO2 highlighting thickened areas of the esophageal wall, thus allowing an accurate quantifica-tion of their extents. Although there are other alterna-tives for distension (oral contrast agents, water and ef-fervescent granules), they may be suboptimal. Patients with locally advanced esophageal cancer have a dismal prognosis despite surgical resection. Therefore, neo-adjuvant treatment strategies using radiation therapy and chemotherapy were developed to improve sur-vival. Neoadjuvant therapy improves esophageal tumor prognosis in a substantial proportion of patients, and the use of imaging techniques is mandatory to detect their response. PnCT combined with virtual endoscopy and multiplanar reconstruction enhances morphologic details in esophageal cancer, and thus would allow animproved assessment of response to neoadjuvant treat-ment. Therefore, more information could be provided to assess the efficacy of pre-surgical treatment. We de-scribe the potential use of PnCT to assess the response to neoadjuvant therapy in esophageal cancer with an imaging pathologic correlation. | Marina Ulla Ernestina Gentile Ezequiel Levy Yeyati Maria L Diez Demetrio Cavadas Ricardo D Garcia-Monaco Pablo R Ros | 2013 | World Journal of Gastrointestinal Oncology2013，5，12： | 3 |
| 4 | Psychosocial mechanisms for the transmission of somatic symptoms from parents to children显示文摘AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.METHODS:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget Sound.Mothers completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health Cooperative.Mothers with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and education.RESULTS:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in children.There was no significant correlation between parental reinforcement of symptoms and child expression of GI or other symptoms.Hypothesis 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in children.Children of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)symptoms.Total health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers exhibit.Methods used by children to cope with stomachaches differed from methods used by their mothers.Only 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and children share psychological traits such as anxiety,depression,and somatization.Child psychological distress correlated with mother’s psychological distress(rho=0.41,P<0.001 for cases,rho=0.38,P<0.001 for controls).Hypothesis 5:stress that affects the whole family might explain the similarities between mothers and their children.Family exposure to stress was not a significant predictor of children’s symptom reports.Hypothesis 6:the intergenerational transmission of GI illness behavior may be due to multiple mechanisms.Regression analysis identified multiple independent predictors of the child’s GI complaints,which were similar to the predictors of the child’s non-GI symptoms(mother’s IBS status,child psychological symptoms,child catastrophizing,and child age).CONCLUSION:Multiple factors influence the reporting of children’s gastrointestinal and non-gastrointestinal symptoms.The clustering of illness within families is best understood using a model that incorporates all these factors. | Miranda AL van Tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 5 | Social learning contributions to the etiology and treatment of functional abdominal pain and inflammatory bowel disease in children and adults显示文摘This paper reviews empirical work on cognitive and social learning contributions to the etiology and treatment of illness behavior associated with functional abdominal pain and inflammatory bowel disease. A particular emphasis is placed on randomized controlled trials, the majority of which are multi-modal in orientation, incorporating elements of cognitive behavioral therapy, social learning, and relaxation. Based on this review, we offer methodological and clinical suggestions: (1) Research investigations should include adequate sample sizes, long-term follow-up assessments, and a credible, active control group. (2) Standard gastrointestinal practice should include, when appropriate, learning opportunities for patients and family members, for example, instruction regarding the encouragement of wellness behavior. | Rona L Levy Shelby L Langer William E Whitehead | 2007 | World Journal of Gastroenterology2007，13，17： | 2 |
| 6 | Evaluation of minor penetrating duodenal iniures显示文摘 | Mckenney MG Nir L Levi DM | 1996 | Am Surg1996，62，11： | 1 |
| 7 | Hydrothermal epitaxy of KTaO3 thin films显示文摘 | GOH G K L LEVI C G LANGE F F | 2002 | J Mater Res2002，17，11： | 1 |
| 8 | An implantable carotid sinus stimulator for drug-resistant hypertension: surgical technique and short-term outcome from the muhicenter phase II Rheos feasibility trial显示文摘 | Illig KA Levy M Sanchez L | 2006 | J Vasc Surg2006，44，6： | 1 |
| 9 | Randomized trial of suture versus electrosurgical bipolar vessel sealing in vaginal hysterectomy显示文摘 | Levy B Emery L | | 0，，01： | 1 |
| 10 | 查看详情显示文摘 | Di B A Gray L K Levy J K | | 0，，： | 1 |
| 11 | Brain MRI of na- sal MOG therapeutic effect in relapsing-progressive EAE 显示文摘 | Levy Barazany H Barazany D Puckett L | 2014 | Exp Neuro12014，255，： | 1 |
| 12 | Second primary cancers in la- ryngeal cancer patients 显示文摘 | Levi F Randimbison L Te VC | 2003 | Eur J Cancer2003，39，2： | 1 |
| 13 | Silica nanobubbles containing an organic dye in a multilayered organic/inorganic heterostructure with enhanced luminescence 显示文摘 | Lal M Levy L Kim K S | 2000 | Chem Mater2000，12，： | 1 |
| 14 | Transient performance of linear induction launchers fed by generators and by capacitor banks 显示文摘 | He J L Zabar Z Levi E | 1991 | IEEE Transactions on Magnetics1991，27，1： | 1 |
| 15 | Palhogenesis and pharmacological strategies for mitigating secondary damage in acute spinal cord injury 显示文摘 | Amar A P Levy M L | 1999 | Neurosurgery1999，44，5： | 1 |
| 16 | Total serum bilirubin and risk of cardiovascular disease in the Framingham of spring study 显示文摘 | Levy D Adrienne L | 2001 | The American Journal of Cardiology2001，87，10： | 1 |
| 17 | Role of theperoxisome proliferator-activated receptor-ganmm (PPAR-gamma) and its natural ligand 15-deoxy-deltal2,14-prostaglandin J2 in the regulation of microglial function显示文摘 | Bernardo A Levi G Minghetti L | 2000 | Eur J Nenrosci2000，12，7： | 1 |
| 18 | The Importance of Instrumentality Beliefs in the Prediction of Organizational Citizenship Behaviors 显示文摘 | Haworth C L Levy P E | 2001 | Journal of Vocational Behavior2001，59，： | 1 |
| 19 | Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery:time limitation and advantage of brain protection显示文摘 | LAVlNE S D MASRI L S LEVY M L | 1997 | J Neurosurg1997，87，6： | 1 |
| 20 | Nanochemistry: synthesis and characterization of muhifunctional nanoclinics for biological applications 显示文摘 | LEVY L SAHOO Y KIM K S | 2002 | Chem Mater2002，14，： | 1 |
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