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| 1 | Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis显示文摘The importance of sphingosine kinase(SphK)and sphingosine-1-phosphate(S1P)in inflammation has been extensively demonstrated.As an intracellular second messenger,S1P plays an important role in calcium signaling and mobilization,and cell proliferation and survival.Activation of various plasma membrane receptors,such as the formyl methionyl leucyl phenylalanine receptor,C5a receptor,and tumor necrosis factor α receptor,leads to a rapid increase in intracellular S1P level via SphK stimulation.SphK and S1P are implicated in various chronic autoimmune conditions such as rheumatoid arthritis, primary Sjgren's syndrome,and inflammatory bowel disease.Recent studies have demonstrated the important role of SphK and S1P in the development of arthritis by regulating the pro-inflammatory responses.These novel pathways represent exciting potential therapeutic targets. | Alirio J Melendez Bernard P Leung | 2010 | World Journal of Biological Chemistry2010，1，11： | 3 |
| 2 | The conversion factor of K_(eff) to K_(3.7) in thermoluminescence dating显示文摘In the fine-grain TL dating the full o dose must be converted into the equivalent P dose. The conversion is finished by Keff-value, which is an effective or effectiveness. But the Keff can not be measured directly for each sample and only the external radiative efficiency K3.7 can be measured. In order to obtain the Keff a special study for the conversion factor of Keff to K3.t has been made using the ultrathin TLD. The results show that the conversion factor of tile TLD for archaeological samples is 0.847, which is in agreement with calculated value 0.85. | Wang Wei-Da Zhou Zhi-Xin Xia Jun-Ding (Research Laborotory for Conservation and Archaeology, Shanghai Museum, Shanghai 200951)Leung P L Stokes M J(Department of Physics and Materials Science, City University of Hong Kong) | 1998 | Nuclear Science and Techniques1998，9，4： | 3 |
| 3 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 4 | Anaerobic bacteria and intrahepatic stones: detections of Clostridium sp. and Bacteroides fragilis显示文摘To detect anaerobic bacteria Clostridium sp . and Bacteroides fragilis in intrahepatic stones by molecular genetic method Methods DNA was extracted from 59 stone samples and subjected to polymerase chain reaction (PCR) amplification targeting the 16S rRNA gene of Clostridium sp . and the glutamine synthetase gene of Bacteroides fragilis Single-strand conformational polymorphism (SSCP) analysis was performed to identify the Clostridium sp Results 16S rRNA gene sequences for Clostridium sp. were identified in 49 stones (83%, 49/59) The two most common groups were detected in 19 (41%) and 17 (37%) of the 46 samples using SSPC analysis, and 25/59 (42%) stones were tested positive for Bacteroides fragilis Conclusions Anaerobes such as Clostridium sp and Bacteroides fragilis present in intrahepatic stones and may play a role in stone formation PCR is a useful technique to detect fastidious pathogens, which are difficult to culture SSCP of PCR products is a rapid method in differentiating bacterial | LIU Yanlei Kan Lam Yajarayma J Tang Paul H Gumerlock Dong Ki Lee Myung Hwa Kim Sum P Lee Joseph SilvaJr Joseph W Leung | 2000 | Chinese Medical Journal2000，，9： | 2 |
| 5 | Afterloading radiotherapy for local persistence of nasopharyngeal carcinoma显示文摘 | Teo P Leung S F Choi P | 1994 | Br J Radiol1994，67，794： | 2 |
| 6 | Sex differences in schizophrenia, a review of the literature显示文摘 | Leung A Chue P | 2000 | Acta Psychiatr Scand Suppl2000，，： | 1 |
| 7 | Clarithromycin resistance and efficacy of clarithromycin-containing triple eradication therapy for Helicobacter pylori infection in type 2 diabetes mellitus patients显示文摘 | Hung IF Chan P Leung S | 2009 | Helicobacter2009，14，6： | 1 |
| 8 | The Ethics and Positioning of Guanxi in China显示文摘 | Leung T K P Wong Y H | 2001 | Marketing Intelligence & Planning2001，，1： | 1 |
| 9 | Man portable power needs of the 21st century显示文摘 | Atwater T B Cygan P J Leung F C | 2000 | J Power Sources2000，91，1： | 1 |
| 10 | A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma显示文摘 | Chan A T Teo P M Leung T W | 1995 | Int J Radiat Oncol Biol Phys1995，33，3： | 1 |
| 11 | Effect of supplementation of leukemia inhibitory factor and epidermal growth factor on murine embryonic development in vitro, implantation, and outcome of offspring显示文摘 | Cheung L P Leung H Y Bongso A | 2003 | Fertil Steril2003，80，2： | 1 |
| 12 | One-step quantitative cortisol dipstick with proportional reading显示文摘 | Leung W Chan P Bosgoed F | 2003 | J Immunol Methods2003，281，12： | 1 |
| 13 | The development of silver-based cadmium-free contact materials显示文摘 | Wingert P C Leung C H | 2004 | Journal of Alloys and Compounds2004，72，3： | 1 |
| 14 | Prognostic factors in nasopharyngeal carcinoma investigated by computer tomographyan analysis of 659 patients显示文摘 | TEO P SHIU W LEUNG S F | 1992 | Radio Oncol1992，23，2： | 1 |
| 15 | Molecular identification of the lobster muscle protein tropomyosin as a seafood allergen 显示文摘 | Leung P S Chen Y C Mykles D L | 1998 | Mol Mar Biol Biotechnol1998，7，1： | 1 |
| 16 | Species sensitivity distributions: data and model choice 显示文摘 | WHEELER J R GRIST E P M LEUNG K M Y | 2002 | Mar Pollut Bull2002，45，： | 1 |
| 17 | Tracking the direction-of- arrival of multiple moving targets by passive arrays: algo- rithm显示文摘 | Zhou Yifeng Yip P C Leung H | 1999 | IEEE Transactions on Signal Processing1999，47，10： | 1 |
| 18 | Pseudolaric acids:isolation,bioactivity and synthetic studies显示文摘 | Chiu P Leung L T Ko B C | | 0，，07： | 1 |
| 19 | Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice 显示文摘 | Chu K Y Leung P S | 2007 | Antioxid Redox Signal2007，9，： | 1 |
| 20 | A Hap-tic Needle Manipulation Simulator for Chinese Acupuncture Learning and Training显示文摘 | Heng P A Wong T T Leung K M | 2006 | International Journal of Image and Graphics2006，6，2： | 1 |
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