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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | 2-Year GLOBE trial results:telbivudine is superior to lamivudine in patients with chronic hepatitis B显示文摘 | Liaw YF Gane E Leung N | | Gastroenterology0，，： | 2 |
| 3 | OFDM for data communication over mobile radio FM channels, Part 1: analysis and experimental results显示文摘 | KASAS E F LEUNG C | 1991 | IEEE Trans on Communications1991，39，5： | 1 |
| 4 | Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy显示文摘 | Sun X Kanwar JR Leung E | 2001 | Gene Ther2001，8，8： | 1 |
| 5 | Regulation of cell adhesion and anchorage-dependent growth by a new β1-interinlinked protein kinase显示文摘 | Hannigan G E Leung Hagecsteijn C Fitz Gibbon L | 1996 | Nature1996，379，6560： | 1 |
| 6 | Species sensitivity distributions: data and model choice 显示文摘 | WHEELER J R GRIST E P M LEUNG K M Y | 2002 | Mar Pollut Bull2002，45，： | 1 |
| 7 | Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy显示文摘 | Sun X Kanwar JR Leung E | | 0，，： | 1 |
| 8 | A novel serine / threonine kinase binding the Ras - related RhoA GTPase which translocates the kinase to peripheral membranes显示文摘 | Leung T Manser E Tan L | 1995 | J Biol Chem1995，270，29： | 1 |
| 9 | Effects of heparin and related drugs on neutrophil function显示文摘 | Brown RA E Leung H Kankaanranta | | 0，，02： | 1 |
| 10 | Regulation of cell adhesion and anchorage-dependent growth by a new β1-interinlinked protein kinase显示文摘 | Hanningan G E Leung Hagecsteijn C Fitz Gibbon L | 1996 | Nature1996，379，6560： | 1 |
| 11 | Gene transfer of antisense hypoxia-inducible factor-1 enhances the therapeutic efficacy of cancer immunotherapy显示文摘 | Sun X Kanwar JR Leung E | 2001 | Gene Therapy2001，8，8： | 1 |
| 12 | Surface enhanced Raman scattering from metallic nanoshells with nonlocal dielectric response显示文摘 | Goude Z E Leung P T | | 0，，8： | 1 |
| 13 | Species sensitivity distributions:data and model choice 显示文摘 | WHEELER J R GRIST E P M LEUNG K M ~ | 2002 | Mar PoUut Bull2002，45，123456789101112： | 1 |
| 14 | Drug metabolites as cytochrome p450 inhibitors: a retrospective analysis and proposed algorithm for evaluation of the pharmacokinetic interaction potential of metabolites in drug discovery and development 显示文摘 | Callegari E Kalgutkar AS Leung L | 2013 | Drug Metab Dispos2013，41，12： | 1 |
| 15 | Acute mesenteric ischemia caused by spontaneous isolated dissection of the superior mesenteric artery: treatment by percutaneous stent placement显示文摘 | Leung DA Schneider E Kubik-Huch R | 2000 | Eur Radiol2000，10，： | 1 |
| 16 | Gene transfer of antisense hypoxia inducible factor 1 alpha enhances the therapeutic efficacy of cancer immunotherapy显示文摘 | Sun X Kanwar JR Leung E | 2001 | Gene Ther2001，8，8： | 1 |
| 17 | Screening of anabolic steroids in horse urine by liquid chromatography-tandem mass spectrometry显示文摘 | Yu N H Ho E N M Leung D K K | 2005 | J Pharm Biomed Anal2005，37，： | 1 |
| 18 | Recombi- nation is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratorysyn- drome viruses in China显示文摘 | Shi M Holmes E C Brar M S Leung F C | 2013 | J Virol2013，87，10： | 1 |
| 19 | A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance显示文摘 | Goleva E Kisich KO Leung DY | 2002 | J Immunol2002，169，10： | 1 |
| 20 | Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats显示文摘 | Print CG Leung E Harrison JE | 1994 | Gene1994，144，2： | 1 |
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