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| 1 | Incident frailty and cognitive impairment by heart failure status in older patients with atrial fibrillation: the SAGE-AF study显示文摘Background Atrial fibrillation(AF) and heart failure(HF) frequently co-occur in older individuals. Among patients with AF, HF increases risks for stroke and death, but the associations between HF and incident cognition and physical impairment remain unknown. We aimed to examine the cross-sectional and prospective associations between HF, cognition, and frailty among older patients with AF. Methods The SAGE-AF(Systematic Assessment of Geriatric Elements in AF) study enrolled 1244 patients with AF(mean age 76 years, 48% women) from five practices in Massachusetts and Georgia. HF at baseline was identified from electronic health records using ICD-9/10 codes. At baseline and 1-year, frailty was assessed by Cardiovascular Health Survey score and cognition was assessed by the Montreal Cognitive Assessment. Results Patients with prevalent HF(n = 463, 37.2%) were older, less likely to be non-Hispanic white, had less education, and had greater cardiovascular comorbidity burden and higher CHA2 DS2 VASC and HAS-BLED scores than patients without HF(all P's < 0.01). In multivariable adjusted regression models, HF(present vs. absent) was associated with both prevalent frailty(adjusted odds ratio [a OR]: 2.38, 95% confidence interval [CI]: 1.64-3.46) and incident frailty at 1 year(a OR: 2.48, 95% CI: 1.37-4.51). HF was also independently associated with baseline cognitive impairment(a OR: 1.60, 95% CI: 1.22-2.11), but not with developing cognitive impairment at 1 year(a OR 1.04, 95%CI: 0.64-1.70). Conclusions Among ambulatory older patients with AF, the co-existence of HF identifies individuals with physical and cognitive impairments who are at higher short-term risk for becoming frail. Preventive strategies to this vulnerable subgroup merit consideration. | Wei-Jia WANG Darleen Lessard Jane Saczynski Robert J Goldberg Alan S.Go Tenes Paul Ely Gracia David D McManus | 2020 | Journal of Geriatric Cardiology2020，17，11： | 2 |
| 2 | Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells显示文摘 | Lessard J Sauvageau G | 2003 | Nature2003，423，6937： | 1 |
| 3 | Bmi-1 determines the proliferative capacity of normal and leukemic stem cells显示文摘 | Lessard J Sauvageau G | 2003 | Nature2003，423，： | 1 |
| 4 | Palliation of recurrent Ewing sarcoma of the pelvis with cryoablation and somatosensory-evoked potentials显示文摘 | Lessard AM Gilchrist J Schaefer L | 2009 | J Pediatr Hematol Oncol2009，31，： | 1 |
| 5 | Sorption of organic matter from four phytoplankton species to montmorillonite, chlorite, and kaolinite in seawater 显示文摘 | Satterberg J Arnarson T S Lessard E J | 2003 | Marine Chemistry2003，81，： | 1 |
| 6 | An essential switch in sub- unit composition of a chromatin remodeling complex during neural development 显示文摘 | Lessard J Wu JI Ranish JA | 2007 | Neuron2007，55，2： | 1 |
| 7 | Regulation of dendritic development by neuron-specific chromatin remodeling complexes显示文摘 | Wu JI Lessard J Olave IA | 2007 | Neuron2007，56，： | 1 |
| 8 | Chronic activation ofwild type epidermal growth factor receptor and loss of Cd-kn2a cause mouse glioblastoma fomiation显示文摘 | Acquaviva J Jun HJ Lessard J | 2011 | Cancer Res2011，71，23： | 1 |
| 9 | Bmi-1 determines the proliferative capaci- ty of normal and leukaemic stem cells显示文摘 | Lessard J Sauvageau G | 2003 | Nature2003，423，6937： | 1 |
| 10 | Differential symptoms of acute myocardial infarction in patients with kidney disease: a community-wide perspective 显示文摘 | Sosnov J Lessard D Goldberg R J | 2006 | Am J Kidney Dis2006，47，3： | 1 |
| 11 | Cryopreservation of boar semen and its future importance to the industry 显示文摘 | Bailey J L Lessard C Jacques J | 2008 | Theriogenology2008，70，： | 1 |
| 12 | Ten-year trends in the incidence,treatment,and outcome of Q-wave myocardial infarction显示文摘 | DAUERMAN H L LESSARD D YARZEBSKI J | 2000 | Am J Cradiol2000，86，7： | 1 |
| 13 | Suicidal ideation in an ado- lescent clinical sample:attachment patterns and clinical impli- eations显示文摘 | LESSARD J C MORETTI M M | 2005 | Journal of Adolescence2005，21，4： | 1 |
| 14 | BMI-1 determines the proliferative capacity of normal and leukaemic stem cells显示文摘 | LESSARD J SAUVAGEAU G | 2003 | Nature2003，423，： | 1 |
| 15 | BMI-1 determines the proliferative capacity of normal and leukaemic stem cells显示文摘 | Lessard J Sauvageau G | 2003 | Nature2003，423，6937： | 1 |
| 16 | Psychologicai insulin resist- ance:patient belief and implications for diabetes management显示文摘 | Brod M Kong J H Lessard S | 2009 | Qual life Res2009，18，： | 1 |
| 17 | Functional antagonism of the Polycomb-Group genes eed and Bmil in hemopoietic cell proliferation 显示文摘 | Lessard J Schumacher A Thorsteinsdottir U | 1999 | Genes Dev1999，13，20： | 1 |
| 18 | Recent insights into the ge- netic basis of systemic lupus erythematosus 显示文摘 | Moser KL Kelly JA Lessard C J | 2009 | Genes Immun2009，10，5： | 1 |
| 19 | Long - term survival after heart failure : a contemporary population - based per- spective显示文摘 | GOLDBERG R J CIAMPA J LESSARD D | 2007 | Arch Intern Med2007，167，5： | 1 |
| 20 | Bmi-1 determines the proliferative capacity of normal and leukemic stem cells显示文摘 | Sauvageau G | 2003 | Nature2003，423，： | 1 |
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