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35篇 您的检索式:作者名="LEONIDAS C"
    题名 作者 年代 出处 被引量
1Mnk kinase pathway: Cellular functions and biological outcomes显示文摘The mitogen-activated protein kinase(MAPK) interacting protein kinases 1 and 2(Mnk1 and Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to the MAPKs(p38 or Erk), multiple studies suggest that the Mnk kinases can be regulated by other known kinases such as Pak2 and/or other unidentified kinases by phosphorylation of residues distinct from the sites phosphorylated by the MAPKs. Several studies have established multiple Mnk protein targets, including PSF, heterogenous nuclear ribonucleoprotein A1, Sprouty 2 and have lead to the identification of distinct biological functions and substrate specificity for the Mnk kinases. In this review we discuss the pathways regulating the Mnk kinases, their known substrates as well as the functional consequences of engagement of pathways controlled by Mnk kinases. These kinases play an important role in mRNA translation via their regulation of eukaryotic initiation factor 4E(eIF4E) and their functions have important implications in tumor biology as well as the regulation of drug resistance to anti-oncogenic therapies. Other studies have identified a role for the Mnk kinases in cap-independent mRNA translation, suggesting that the Mnk kinases can exert important functional effects independently of the phosphorylation of eIF4 E. The role of Mnk kinases in inflammation and inflammationinduced malignancies is also discussed.Sonali Joshi Leonidas C Platanias 2014World Journal of Biological Chemistry2014,5,3:16
2Successful treatment of pit- yriais rubra pilaris with adalimumab-case report 显示文摘Bravo EA Leonidas C Paucar SM 2014Dermatology Online Journal2014,20,22:1
3Statins in tumor suppression 显示文摘ANTONELLA S LEONIDAS C P 2008Cancer Lett2008,260,12:1
4Value differences as determinants of importers' perceptions of exporters un- ethical behavior: the impact on relationship quality and performance 显示文摘Constantinos N L Leonidas C L 2013International Business Review2013,,22:1
5Abnormalities in Thl7 T cells in aplastic Anemia显示文摘Leonidas C 2011Blood2011,116,20:1
6Pyloric volume:an important factor in the surgeon,s ability to palpate the pyloric 'Olive'in hypertrophic pyloriec stenosis显示文摘Ozsrath R Poustchi-Amin M Leonidas C 1997Pediatric Radiol1997,27,:1
7Industrial Buyer's Influence Strategies: Buying Situation Differences 显示文摘Leonidou Leonidas C 2005The Journal of Business & Industrial Marketing2005,20,1:1
8Langerhans'cell histiocytosis 显示文摘Leonidas J C Guelfguat M Valderrama E 2003Lancet2003,361,9365:1
9Kinetics studies of Trichlorophenol destruction by chelate-based Fenton reaction显示文摘Li Y C Leonidas G 2005Environmental Engineering Science2005,22,6:1
10Kinetics studies of Trichlorophenol destruc- tion by chelate based Fenton reaction显示文摘Li Y C Leonidas G 2005Environmental Engi-neefing Science2005,22,6:1
11Exercised power as a driver of trust and commitment in cross - border industrial buyer seller relationships 显示文摘LEONIDAS L C TALIAS M A LEONIDOU C N 2008Industrial Marketing Management2008,37,1:1
12Psychiatric readmission: an integrative review of the literature显示文摘Machado V Leonidas C Santos MA 2012Int Nurs Rev2012,59,4:1
13Platanias : AMP-activaled kinase ( AMPK ) -gener- atedsignals in malignant melanoma cell growth and survival 显示文摘Jennifer Woodard Leonidas C 2010Biochem Bio- phys Res Cmmun2010,398,1:1
14New group contribution method for estimating properties of pure compounds显示文摘Leonidas C Rafiqul G 1994AIChE J1994,40,10:1
15Industrial manufacturer-customer relationships: The discriminating role of the buying situation显示文摘Leonidas C L 2004Industrial Marketing Management2004,33,8:1
16Dynamicreliability under random shocks显示文摘GUNTER B LEONIDAS C DIMITRIS K 2002Reliability Engineeringand System Safety2002,77,3:1
17显示文摘Palilis Leonidas C 2008Organic Electronics2008,9,5:1
18Dynamic reliability under random shocks显示文摘GUNTER B LEONIDAS C DIMITRIS K 2002Reliability Engineering and System Safety2002,77,3:1
19Gastriesophageal reflux in infants and children: a useful classification and reliable physiologic technique for its demonstration 显示文摘MeCauley R G K Darling D B Leonidas J C 1978Am J Roentgenol1978,130,1:1
20Efficient silole-based organic light-emitting diodes rsing high conductivity polymer anodes显示文摘Woohong K Leonidas C Manabu U 2004Chemistry Materials2004,16,:1
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