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514篇 您的检索式：作者名="LEONG L"

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	题名	作者	年代	出处	被引量
1	Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds.	Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun	2015	Bone Research2015，3，3：	4
2	Factors affecting the filter paper method for total and matric suction measurements显示文摘	LEONG E C HE L RAHARDJO H	2002	Geotechnieal Testing Journal2002，25，3：	1
3	Regression of metastatic carcinoid tumors with octreotide therapy:Two case reports and a review of the literature显示文摘	Leong WL Pasieka J L	2002	J Surg Oncol2002，79，3：	1
4	Targeted inhibition of STAT3 with a decoy oligonucleotide abrogates head and neck cancer cell growth显示文摘	Leong P L Andrews G A Johnson D E	2003	Proc Natl Acad Sci USA2003，100，7：	1
5	Dual-polarized slotcoupled planar antenna with wide bandwidth显示文摘	GAO S LI L LEONG M YEO T	2003	IEEE Transactions on Antennas Propagat2003，51，：	1
6	查看详情显示文摘	Leong W L Mathews N Tan B Vaidyanathan S Dotz F Mhaisalkar S		0，，：	1
7	Patient advocacy and arthritis:moving forward显示文摘	Leong AL Euller-Ziegler L	2004	Bull World Health Organ2004，82，2：	1
8	Depletion of langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘	MATTHEWS K LEONG C M BAXTER L	2003	J Virol2003，77，：	1
9	Genome organization of Magnaporthe grisea: integration of genetic maps, clustering of transposable elements and identification of genome duplications and rearrangments显示文摘	Nitta N Farman M L Leong S A	1997	Theor Appl Genet1997，95，：	1
10	Angiogenesis inhibitors in the treatment of epithelial ovarian cancer 显示文摘	Hart ES Wakabayashi M Leong L	2013	Curr Treat Options Oncol2013，14，1：	1
11	A numerical study of solidification of n-hexadecane based on the enthalpy formulation 显示文摘	Duan Q Tan F L Leong K C	2002	Journal of Materials Processing Technology2002，120，1：	1
12	Depletion of Langerhans cells in human papillomavirus type 16-Infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘	Matthews K Leong CM Baxter L	2003	J Virol2003，77，15：	1
13	Comparison of methods tor determination of organic carbon in marine sediment 显示文摘	Leong L S Tanner P A	1999	Marine Pollution Bulletin1999，38，10：	1
14	Depletion of langerhans cells in human papillomavirus type 16-Infected skin is associated with E6-mediated down regulation of E-cadherin显示文摘	Matthews K Leong CM Baxter L	2003	J Virol2003，77，15：	1
15	Is plasma N-BNP a good indicator of the functional reserve of failing hearts显示文摘	Simon G Williams Leong L Ng Russell J O'Brien	2004	The European Journal of Heart Failure2004，6，：	1
16	Electromagnetic dyadic Green' s function in spherically multi-layered media显示文摘	Li L W Kooi P S Leong M S	1994	IEEE Transactions on Microwave Theory and Techniques1994，42，12：	1
17	Carbon-supported Pt Nanoparticles as Catalysts for Proton Exchange Membrane Fuel Cells 显示文摘	Liu Z L Leong M G Liang H	2005	J Power Sources2005，139，：	1
18	Responses to laboratory psychosocial stress in postpartum women 显示文摘	Altemus M Redwine L S Leong Y	2001	Psychsom Med2001，63，：	1
19	Hazardous foreign bodies:cornplieations and management of button batteries in nose显示文摘	LOH W S LEONG J L TAN H K	2003	Ann Otol Rhinol Laryngol2003，1，12：	1
20	Hazardous foreign bodies:complications and management of button batteries显示文摘	LOH W S LEONG J L TAN H K	2003	Ann Otol Rhinol Laryngo2003，112，：	1

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