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| 1 | Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics显示文摘AIM: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS: When the patients underwent a 'breath test', 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative 'breath test' one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, 'breath test' remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative 'breath test' in one patient only. CONCLUSION: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a 'breath test' with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO. | I Esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Concept of histone deacetylases in cancer:Reflections on esophageal carcinogenesis and treatment显示文摘Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type world-wide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and altering expression of genes important in the cell cycle, differentiation and apoptosis. Based on this knowledge, histone acetylation was addressed as a potential novel chemotherapy drug target to repress cancer cell proliferation. There are four classes of histone deacetylases (HDACs) inhibitors with a variety of different mechanisms of actions that render them possible anticancer drugs. They arrest the cell cycle, inhibit differentiation and angiogenesis and induce apoptosis. They do not necessarily act on histone proteins, since they can also exert indirect anti-cancer effects, by modifying various cellular proteins.In addition,HDACs have also been associated with increased chemotherapy resistance.Based on the literature,HDACs have been associated with EC,with surveys revealing that increased expression of certain HDACs correlates with advanced TNM stages,tumor grade,metastatic potential and decreased 5-year overall and disease-free survival.The aim of this survey is to elucidate the molecular identity and mechanism of action of HDAC inhibitors as well as verify their potential utility as anti-cancer agents in esophageal cancer. | Dimitrios Schizas Aikaterini Mastoraki Leon Naar Eleftherios Spartalis Diamantis I Tsilimigras Georgia-Sofia Karachaliou George Bagias Dimitrios Moris | 2018 | World Journal of Gastroenterology2018，24，41： | 3 |
| 3 | Carbon monoxide intoxication: An updated review 显示文摘 | Leon D P Rossitza I C | 2007 | Journal of the Neurological Sciences2007，262，： | 1 |
| 4 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 5 | Reduced sensorimotor inhibition in the ipsilesional motor cortex in a patient with chronic stroke of the paramedian thalamus显示文摘 | Oliviero A Leon AM Holier I | 2005 | Clin Neurophysiol2005，116，11： | 1 |
| 6 | Feed-forward space vector modulation for single- phase multilevel cascaded converters with any DC voltage ratio显示文摘 | Jose I Leon Sergio Vazquez Alan J Watson | 2009 | IEEE Transactions on Industry applications2009，56，2： | 1 |
| 7 | Power-electronic systems for the grid integration of renewable energy sources: A survey 显示文摘 | CARRASCO J M FRANQUELO L G BIALASIEWICZ J T GALVAN E GUISADO R C P PRATS M A M LEON J I MORENO N | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 8 | Impact of sirolimus-eluting stents on outcome in diabetic patients:a SIRIUS (SIRolImUS-coated Bx Velocity balloon-expandable stent in the treatment of patients with de novo coronary artery lesions) substudy显示文摘 | Moussa I Leon MB Baim DS | | Circulation0，109，19： | 1 |
| 9 | Is salicylic acid a translocated signal of systemic acquired resistance in tobacco 显示文摘 | Shulaev V Leon J Raskin I | 1995 | Plant Cell1995，7，： | 1 |
| 10 | Effect of catheter-based iridium-192 gamma brachytherapy on the added risk of restenosis from diabetes mellitus after intervention for in-stent restenosis (subanalysis of the GAMMA I randomized trial)显示文摘 | Moses JW Moussa I Leon MB | 2002 | Am J Cardiol2002，90，3： | 1 |
| 11 | The assessment of a plasma melatonin assay using gas chromatography negative ion chemical ionization mass spectrometry显示文摘 | Skene D J Leone R M Young I M | 2002 | J Chromatogr B2002，775，： | 1 |
| 12 | The age of multilevel converters arrives显示文摘 | Franquelo Leopoldo G Rodriguez Jose Leon Jose I | 2008 | IEEE Industrial Electronics Magazine2008，2，2： | 1 |
| 13 | Inhibition of neuronal nitric oxide synthase activity by Nl-acetyl-5- methoxykynuramine, a brain metabolite of melatonin显示文摘 | Leon J Escames G Rodriguez M I | 2006 | J Neurochem2006，98，6： | 1 |
| 14 | Gabapentin increase slow--wave sleep in normal adults显示文摘 | Foldvary--Schaefer N De leon Sanehezt I Karafa M | 2002 | Epilepsia2002，43，12： | 1 |
| 15 | Impact of sirolimus-eluting stent on outcome in diabetes patients: a SIRIUS(sirolimus-coated Bx velocity balloon-expandable stent in the treatment of patients with de novo coronary artery lesions) substudy 显示文摘 | Moussa I Leon MB Baim DS | 2004 | Circulation2004，109，： | 1 |
| 16 | Impact of sirolimus-eluting stents on outcomein diabetic patients:a SIRIUS (SIRolImUS-coated Bx Velocity balloon-expandable stent in the trentment of patients with de novo coronary artery lesions) substudy显示文摘 | Moussa I Leon MB Baim DS | 2004 | Circulation2004，109，19： | 1 |
| 17 | Conventional space-vector modulation techniques versus the single-phase modulator for multilevel converters显示文摘 | Leon J Vazquez I S Sanchez J A | 2010 | IEEE Trans on Industrial Electronics2010，57，7： | 1 |
| 18 | Standardized procedures for planting vegetation on completed sanitary landfills显示文摘 | GILMAN E F FLOWER F B LEONE I D | 1985 | Waste management research1985，3，1： | 1 |
| 19 | Parametric analysis of steel bolted end plate connections using finite element modeling显示文摘 | MAGGI Y I GONCALVES R M LEON R T | 2005 | Journal of Constructional Steel Research2005，61，： | 1 |
| 20 | Impact of sirolimus-eluting stents on outcome in diabetic patients:a SIRIUS (SIRollmUScoated Bx Velocity balloon-expandable stent in the treatment of patients with de novo coronary artery lesions) substudy显示文摘 | Moussa I Leon MB Baim DS | 2004 | Circulation2004，109，： | 1 |
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