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| 1 | Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model显示文摘骨头骨折愈合的起始的煽动性的阶段为愈合的过程的结果代表关键步。然而,开始这个煽动性的阶段的机制和在破裂地点在场的有免疫力的房间的功能糟糕被理解。以便在破裂 hematoma 以内学习早事件,我们建立了一在里面 vitro 破裂 hematoma 模型:我们有教养的 hematomas 在 bioenergetically 控制的条件下面在 vitro 在全部的新潮的关节造形术(THA ) 期间在腿节的截骨术(人工的骨头破裂) 期间形成。这个模型允许我们在跟随破裂的早阶段期间监视有免疫力的房间人口,房间幸存和 cytokine 表示。而且,这个模型使我们能改变 bioenergetical 条件以便模仿在里面 vivo 状况,它被假定被组织缺氧描绘并且限制了营养素的数量。用这个模型,我们发现有免疫力的房间经由 angiogenic 因素, chemoattractants 和支持 inflammatory 分子的表示适应组织缺氧。另外,联合了氧的限制,滋养的供应与 myeloid 的比较提高了淋巴细胞的选择幸存导出的房间(即, neutrophils ) 。笔记,非限制的 bioenergetical 条件没关于 cytokine 表示或有免疫力的房间子集的不同幸存率显示出任何类似的效果。在结论,我们发现 bioenergetical 条件在导致骨折愈合的起始的煽动性的阶段的关键因素之中并且因此是为在早破裂 hematoma 影响有免疫力的房间的幸存和功能的一个关键步骤。 | Paula Hoff Patrick Maschmeyer Timo Gaber Tabea Schiitze Tobias Raue Katharina Schmidt-Bleek Rene Dziurla Saskia Schellmann Ferenz Leonard Lohanatha Eric Rohner Andrea Ode Gerd-Riidiger Burmester Georg N Duda Carsten Perka Frank Buttgereit | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 2 | Coordinated patterns of unit speed particles on a closed curve显示文摘 | ZHANG F LEONARD N E | 2007 | Systems and Control Letters2007，56，6： | 1 |
| 3 | Gut barrier failure in experimental obstructive jaundice显示文摘 | Reynolds JV Murchan P Leonard N et a1 | 1996 | JSurgRes1996，62，1： | 1 |
| 4 | Maternal health in pregnancy and intellectual disability in the offspring:a populationbased study显示文摘 | Leonard H de Klerk N Bourke J | 2006 | Ann Epidemiol2006，16，： | 1 |
| 5 | Cooperative control of mobile sensor networks: Adaptive gradient climbing in a distributed environment显示文摘 | Ogren P Fiorelli E Leonard N E | 2004 | Automatic Control2004，49，8： | 1 |
| 6 | Model-based feedback control of autonomous underwater gliders 显示文摘 | LEONARD N E CRAVER J G | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 7 | Patent duetus arteriosus and its treatment as risk factors for neonatal and neurodevelopmental morbidity显示文摘 | Chorne N Leonard C Piecueh R | 2007 | Pediatrics2007，119，： | 1 |
| 8 | Polybrominated diphenyl ether eontamination levels in fish from the Antarc- tic and the Mediterranean Sea 显示文摘 | Borghesi N Corsolini S Leonards P | 2009 | Chemosphere2009，77，5： | 1 |
| 9 | Triclosan:Applications and safety显示文摘 | BHARGAVA H N LEONARD P A | 1996 | AJIC Am J Infect Control1996，24，3： | 1 |
| 10 | Brentuximab vedotin (SGN-35) for relapsed CD30-poskive lymphomas显示文摘 | Younes A Bartlett N L Leonard J P | 2010 | N Engl J Med2010，363，19： | 1 |
| 11 | A multi-level model of group cognitive style in strategic decision making 显示文摘 | Leonard N H | 2005 | Journal of Managerial Issues2005，17，1： | 1 |
| 12 | Trust in Consumer- to-Consumer Electronic Commerce 显示文摘 | JONES K LEONARD L N K | 2008 | Information & management2008，45，2： | 1 |
| 13 | Quality assurance for Duchenne and Becker muscular dystrophy genetic testing:development of a genomic DNA reference material panel显示文摘 | Kalman L Leonard J Gerry N | | 0，，02： | 1 |
| 14 | Collective motion, sensot networks and ocean sampling 显示文摘 | LEONARD N E PALEY D A LEKIEN F | 2007 | Proceedings of the IEEE2007，95，1： | 1 |
| 15 | The simulated microgravity environment maintains key metabolic functions and promotes aggregation of primary porcine hepatocytes显示文摘 | KONSTANTIONS J D LEONARD J N TIMOTHY J B | 2001 | Biochimica et Biophysica Acta2001，1526，： | 1 |
| 16 | Examples of the use of fluorescent heterocycles in chemistry and biology显示文摘 | Thomas R W Leonard N J | 1976 | Heterocycles1976，5，： | 1 |
| 17 | Trust in consumer-to-consumer electronic commerce显示文摘 | Jones K Leonard L N K | 2008 | Information&Management2008，45，2： | 1 |
| 18 | Nonlinear gliding stability and control for vehicles with hydrodynamic forcing 显示文摘 | BHATTA P~ LEONARD N E | 2008 | Automatica2008，44，5： | 1 |
| 19 | Triclosan:Applications and safety显示文摘 | Bhargava H N Leonard P A | | 0，，03： | 1 |
| 20 | Tacit Knowledge in Academia: A Proposed Model and Measurement Scale 显示文摘 | LEONARD N INSCH G S | 2005 | The Journal of Psychology2005，139，6： | 1 |
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