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| 1 | Strengthening population medicine to promote public health显示文摘As we enter.2022,we are facedwith the fact that coronavirus disease2019(CovID-19)has been devastating the world formore than 2full years.Since the original outbreak of COVID-19in December2019,the disease has proved to be a major threat to global health and,perhaps more importantly,one that is not likely to be resolved soon.Severe_acute respiratory syndrome coronavirus. | Chen Wang Simiao Chen Guangliang Shan Zhiwei Leng Till Bärnighausen Weizhong Yang | 2022 | Chinese Medical Journal2022，，10： | 3 |
| 2 | Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms显示文摘Cadmium(Cd)is a nonessential heavy metal and a prevalent environmental toxin that has been shown to induce significant cardiomyocyte apoptosis in neonatal murine engineered cardiac tissues(ECTs).In contrast,zinc(Zn)is a potent metallothionein(MT)inducer,which plays an important role in protection against Cd toxicity.In this study,we investigated the protective effects of Zn against Cd toxicity in ECTs and explore the underlying mechanisms.ECTs were constructed from neonatal ventricular cells of wild-type(WT)mice and mice with global MT gene deletion(MT-KO).In WT-ECTs,Cd(5−20μM)caused a dose-dependent toxicity that was detected within 8 h evidenced by suppressed beating,apoptosis,and LDH release;Zn(50−200μM)dose-dependently induced MT expression in ECTs without causing ECT toxicity;co-treatment of ECT with Zn(50µM)prevented Cd-induced toxicity.In MT-KO ECTs,Cd toxicity was enhanced;but unexpectedly,cotreatment with Zn provided partial protection against Cd toxicity.Furthermore,Cd,but not Zn,significantly activated Nrf2 and its downstream targets,including HO-1;inhibition of HO-1 by a specific HO-1 inhibitor,ZnPP(10µM),significantly increased Cd-induced toxicity,but did not inhibit Zn protection against Cd injury,suggesting that Nrf2-mediated HO-1 activation was not required for Zn protective effect.Finally,the ability of Zn to reduce Cd uptake provided an additional MT-independent mechanism for reducing Cd toxicity.Thus,Zn exerts protective effects against Cd toxicity for murine ECTs that are partially MT-mediated.Further studies are required to translate thesefindings towards clinical trials. | Hai-tao Yu Juan Zhen Jian-xiang Xu Lu Cai Ji-yan Leng Hong-lei Ji Bradley B Keller | 2020 | Acta Pharmacologica Sinica2020，41，5： | 3 |
| 3 | A mesoporous silica supported Hg^2+ chemodosimeter显示文摘 | Leng B Jiang J Tian H | 2010 | Aiche Journal2010，56，11： | 1 |
| 4 | Cloning of Beauveria bassiana chitinase gene Bbchitl and its application to improve fungal strain virulence显示文摘 | Fang W G Leng B Xiao Y H | 2005 | Appl Environ Microbiol2005，71，： | 1 |
| 5 | TLR3signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71infection显示文摘 | Zhu K Yang J Luo K Yang C Zhang N Xu R Chen J Jin M Xu B Guo N Wang J Chen Z Cui Y Zhao H Wang Y Deng C Bai L Ge B Qin C F Shen H Yang C F Leng Q | 2015 | PLoS Pathog2015，11，10： | 1 |
| 6 | Speckle Suppression in Dig- ital Holographic Imaging with Random Phases and Differ- ent Wavelengths显示文摘 | LENG J SANG X YAN B | 2014 | Optical Engineering2014，53，03： | 1 |
| 7 | Hetero-arrays of Porphyrins and Phthalocyanines显示文摘 | Lo P C Leng X B Dennis K P N | 2007 | Coord Chem Rev2007，251，1720： | 1 |
| 8 | Relationships of lipoealin 2 with breast tumorigenesis and metastasis 显示文摘 | Leng X Wu Y Arlinghaus R B | 2011 | J Cell Physiol2011，226，2： | 1 |
| 9 | The role of ABA in triggering ethylene biosynthesis and ripening of tomato fruit显示文摘 | Zhang M Yuan B Leng P | 2009 | J Exp Bot2009，60，： | 1 |
| 10 | Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abefa precursor protein (APP) transgenic mice 显示文摘 | Lee EB Leng LZ Zhang B | 2006 | J Bid Chem2006，281，7： | 1 |
| 11 | Effect of prolactin in an ex- perimental model of the ovarian hyperstimulation syndrome 显示文摘 | Leng P Ho Yuen B Moon YS | 1983 | Am J Obstet Gynecol1983，145，： | 1 |
| 12 | Pathological study of thoracic impact injury involving a relatively static impact pattern 显示文摘 | Liu B Wang Z Leng H | 1996 | J Trauma1996，40，3： | 1 |
| 13 | Speckle Noise Reduction in Digital Holography with Spatial Light Modulalor And Nonlocal Means Algorithm 显示文摘 | LENG J SANG X YAN B | 2014 | Chinese Optics Letters2014，12，04： | 1 |
| 14 | The role of ABA in triggering peach and grape fruits显示文摘 | Zhang M Yuan B Leng P | 2009 | J Plant Physiol2009，，166： | 1 |
| 15 | Supramolecular Structure of fl-Cyclodextrin and Poly(ethylene oxide)- block-poly(propylene oxide)-block-poly(ethylene oxide) Inclusion Complexes显示文摘 | Tsai CC Leng SW Jeong KU Van Horn RM Wang CL Zhang WB Graham M J Huang J Ho RM Chen YM Lotz B Stephen Cheng ZD | 2010 | Macromolecules2010，43，22： | 1 |
| 16 | Grain characteristicand texture evolution in friction stir welds ofnanostructured oxide dispersion strengthened ferriticsteel 显示文摘 | HAN W T WAN F R LENG B | 2011 | Science and Technology of Welding and Joining2011，16，8： | 1 |
| 17 | Determination of MMP activity using biotinylated gelatin显示文摘 | Ratnikov B Deryugina E Leng J | 2000 | Anal Biochem2000，286，1： | 1 |
| 18 | A shift-invariant filtered backprojection (FBP) cone-beam reconstruction algorithm for the source trajectory of two concentric circles using an equal weighting scheme显示文摘 | ZHUANG T NETT B E LENG S H | 2006 | Physics in Medicine and Biology2006，51，12： | 1 |
| 19 | The role of ABA in triggering ethylene biosynthesis and ripening of tomato fruit显示文摘 | Zhang M Yuan B Leng P | 2009 | J Exp Bot2009，60，6： | 1 |
| 20 | The research of image collection methodfor sediment online-detection显示文摘 | Xiao Y Peng XG Leng M Zhu B | 2010 | Journal of computes2010，5，6： | 1 |
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