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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 3 | Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors显示文摘Helicobacter pylori(H.pylori)is a Gram-negative bacterium that infects about half of the world's population.H.pylori infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged H.pylori infection.In this sense,small regulatory RNAs(sRNAs)are important macromolecules capable of inhibiting and activating gene expression.This function allows sRNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial infections.Recent discoveries have shown that nickelregulated small RNA(NikS)is a post-transcriptional regulator of virulence properties of H.pylori,including the oncoprotein CagA.Notably,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of CagA.In addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients without.With that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of H.pylori and the potential clinical repercussions of this modulation. | Fabrício Freire de Melo Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Lorena Sousa de Carvalho Cláudio Lima Souza Márcio Vasconcelos Oliveira | 2022 | World Journal of Clinical Cases2022，10，31： | 2 |
| 4 | Combination therapy with Abciximab reduces angiographically evident thrombus in acute myocardial infarction: A TIMI 14 substudy显示文摘 | Gibson C M de Lemos J A Murphy S A | 2001 | Circulation2001，103，21： | 1 |
| 5 | The search for a biomarker of cardiac ischemia显示文摘 | MORROW D A DE LEMOS J A SABATINE M S | 2003 | Clin Chem2003，49，： | 1 |
| 6 | Protection from UV- induced skin carcinogenesis by genetic inhibition of the ataxia telangi-ectasia and Rad3-related(ATR )kinase显示文摘 | Kawasumi M Lemos B Bradner JE | 2011 | Proc Natl Acad Sci USA2011，108，13： | 1 |
| 7 | Combination therapy with abciximab reduces an giographieally evident thrombus in acute myocardial infarc tion: aTIMI 14 substudy显示文摘 | GIBSON C M DE LEMOS J A MURPHY S A | 2001 | Circulation2001，103，21： | 1 |
| 8 | Evaluation of B-type natriuretic peptide for risk assessment in unstable angi-na/non-ST-elevation myocardial infarction;B-type natriuretic peptide and prognosis in TACTICS-TIMI 18显示文摘 | Morrow D A de Lemos J A Sabatine M S | | 0，，： | 1 |
| 9 | Homology of V ibrioangullirium strains causing epizootics in turbot,salmon and trout reared on the Atlantic coast of Spain显示文摘 | Toranzo A E Santos Y Lemos M L | 1987 | Aquaculture1987，67，： | 1 |
| 10 | Responses of Stylosanthes humilis (Fabaceae) populations to saline stress显示文摘 | Lovato M B De Lemos Filho J P Martins P S | 1999 | Environmental and Experimental Botany1999，41，： | 1 |
| 11 | 显示文摘 | Dzikh I P Lopes J M Lemos F | 1999 | Appl Catal A1999，176，2： | 1 |
| 12 | Risk Management in the Lusoponte Concession--A Case Study of the Two Bridges in Lisbon Portugal显示文摘 | EATON D BETTS M | 2004 | International Journal of Project Management2004，22，1： | 1 |
| 13 | Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells显示文摘 | Allenspach E J Lemos M P Porrett P M | 2008 | Immunity2008，29，5： | 1 |
| 14 | 显示文摘 | Dzikh I P Lopes J M Lemos F | 2001 | Catal Today2001，65，24： | 1 |
| 15 | On the Mathematical Description and Simulation of ]51rbulent Flow in a Porous Medium Formed by an Array of Elliptic Rods 显示文摘 | Pedras M H J de Lemos M J S | 2001 | Journal of Fluids Engineering2001，123，： | 1 |
| 16 | Population and computational analysis of the MGEA6 P521A variation as a risk factor for familial idiopathic basal ganglia calcification(Fahr's disease)显示文摘 | Lemos RR Oliveira DF Zatz M | 2011 | J Mol Neurosci2011，43，3： | 1 |
| 17 | Porgnostic utili- ty of heart- type fatty acid binding protein in patients with acute coronary syndromes显示文摘 | O'Donoghue M de Lemos JA Mororw DA | 2006 | Circulation2006，114，5： | 1 |
| 18 | On-line system for preconcentration and determination of metals in vegetables by inductively coupled plasma optical emission spectrometry显示文摘 | BEZERRA M A dos SANTOS W N L LEMOS V A | 2007 | Journal of Hazardous Materials2007，148，12： | 1 |
| 19 | B-type natriuretic peptide in cardiovascular disease显示文摘 | De Lemos J A McGuire D K Drazner M H | 2003 | Lancet2003，362，： | 1 |
| 20 | Effects of soy phytoestrogens genistein and daidzein on breast cancer growth 显示文摘 | de Lemos M | 2001 | Ann Pharmacother2001，35，9： | 1 |
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