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| 1 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 2 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 3 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 4 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 5 | Transmission capacity: availability, maximum, transfer and reliability显示文摘 | Leite da S A M de Carvalho C J G da Fonseca M L A | 2002 | IEEE Transactions on Power Systems2002，17，3： | 1 |
| 6 | Laminated three-dimensional biodegradable foams for use in tissue engineering显示文摘 | Mikos A G Sarakinos G Leite S M | 1993 | Biomaterials1993，14，： | 1 |
| 7 | Application of chronological load modeling in composite reliability worth evaluation显示文摘 | Mello J C O Pereira M V F Leite da Silva A M | 1997 | Electric Power Systems Research1997，，40： | 1 |
| 8 | Probabilistic load flow by a multi-linear simulation algorithm显示文摘 | LEITE D A SILVA A M ARIENTI V L | 1990 | IEE Proc on Generation Transmission and Distribution1990，137，4： | 1 |
| 9 | NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat显示文摘 | Beswick R A Dorrance A M Leite R | 2001 | Hypertension2001，38，5： | 1 |
| 10 | 显示文摘 | Sousa V C Leite E R Varela J A | 2002 | J Europ Ceram Soc2002，22，： | 1 |
| 11 | A multi scale directional operator and morphological tools for Reconnecting broken ridges in finger- print images显示文摘 | Oliveira M A Leite N J | 2008 | Pattern Recognition2008，41，： | 1 |
| 12 | Solving optimal power flow problems using a probabilistic α-constrained evolutionary approach显示文摘 | Honorio L M Leite da Silva A M Barbosa1D A | | 0，，06： | 1 |
| 13 | Brown pigment of the nanopowder spinel ferrite prepared by combustion reaction显示文摘 | COSTA A C F M LEITE A M D FERREIRA H S | | 0，，： | 1 |
| 14 | Probabilistic load flow by a multilinear simulation algorithm显示文摘 | Leite de Silva A M Arienti V L | 1990 | IEE Proceedings C Generation Transmission and Distribution1990，137，4： | 1 |
| 15 | Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication 显示文摘 | SOARES J A LEITE F G ANDRADE L G | 2009 | J Virol2009，83，13： | 1 |
| 16 | Peritumoral brain edema in benign meningiomas: correlation with clinical, radiologic, and surgical factors and possible role on recurrence 显示文摘 | Simis A Pires de Agniar PH Leite CC | 2008 | Surg Neurol2008，70，5： | 1 |
| 17 | Particle growth during calcinations of polycation oxides synthesized by the polymeric precursors method 显示文摘 | Leite E R Nobre M A Cerqueira M | 1997 | J Am Ceram Soc1997，80，10： | 1 |
| 18 | Assess-ment of the microbial diversity of Brazilian kefirgrains byPCR-DGGE and pyrosequencing analysis显示文摘 | Leite A M O Mayoa B Rachid C T C C | 2012 | Food Mi-crobiology2012，31，： | 1 |
| 19 | Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia gravis 显示文摘 | Vincent A Leite MI | 2005 | Curr Opin Neurol2005，18，5： | 1 |
| 20 | Homogeneous three-cell networks显示文摘 | LEITE M D C A GOLUBITSKY M | 2006 | Nonlinearity2006，19，： | 1 |
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