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| 1 | High doses of α-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 response显示文摘伪 - Galactosylceramide (伪 - GC ) 广泛地被知道激活不变的自然漂亮 T (iNKT ) 压制髓磷脂的房间抗原特定的 Th1 回答,保护易受影响的老鼠免于试验性的自体免疫的脑脊髓炎(EAE ) 。这里,我们表明那高加重,而非改善的伪 - GC 开 EAE 的意外发现。当与高剂量的伪 - GC 对待的 MOG35-55-specific T 房间被变成 na 时,类似的结果被观察 ? ve syngeneic 接受者老鼠。进一步的学习证明伪 - GC 的高剂量直接通过 STAT3 的 phosphorylation 和 NF-魏 B 的激活由 CD4+CD44+ 记忆 T 房间的激活提高 Th17 和 Th1 反应。不同于由伪 - GC 的低剂量的 iNKT 房间的激活,伪 - GC 的高剂量直接交往了, CD1d 在 T 房间上表示了并且激活 Th17 和 Th1 房间。而且,介绍抗原的房间(APC ) 主要表示 CD1d1,而 CD4+ T 房间快车 CD1d2 的多数。由 RNAi 的 CD1d1 或 CD1d2 基因表示击倒分别地防碍 iNKT 或 Th17/Th1 房间的激活。因此,伪 - GC 处理能改善或变得更坏由雇佣取决于剂量的 APC 或 Th17/Th1 房间的 EAE 使用了。 | Gaochao Qian Xia Qin Ying Qin Zang Baoxue Ge Taylor B Guo Bing Wan Lei Fang Jingwu Z Zhang | 2010 | Cell Research2010，20，4： | 3 |
| 2 | A review on MBE-grown HgCdSe infrared materials on GaSb(211)B substrates显示文摘We review our recent efforts on developing HgCdSe infrared materials on Ga Sb substrates via molecular beam epitaxy(MBE) for fabricating next generation infrared detectors with features of lower production cost and larger focal plane array format size. In order to achieve high-quality HgCdSe epilayers, ZnTe buffer layers are grown before growing HgCdSe, and the study of misfit strain in ZnTe buffer layers shows that the thickness of ZnTe buffer layer needs to be below 300 nm in order to minimize the generation of misfit dislocations. The cut-off wavelength/alloy composition of HgCdSe materials can be varied in a wide range by varying the ratio of Se/Cd beam equivalent pressure during the HgCdSe growth.Growth temperature presents significant impact on the material quality of HgCdSe, and lower growth temperature leads to higher material quality for HgCdSe. Typically, long-wave infrared HgCdSe(x = 0.18, cut-off wavelength of 10.4 μm at 80 K) presents an electron mobility as high as 1.3×10~5cm^2·V^(-1)·s^(-1), a background electron concentration as low as 1.6×10^(16)cm^(-3), and a minority carrier lifetime as long as 2.2 μs. These values of electron mobility and minority carrier lifetime represent a significant improvement on previous studies of MBE-grown HgCdSe reported in the open literatures,and are comparable to those of counterpart HgCdTe materials grown on lattice-matched CdZnTe substrates. These results indicate that HgCdSe grown at the University of Western Australia, especially long-wave infrared can meet the basic material quality requirements for making high performance infrared detectors although further effort is required to control the background electron concentration to below 10^(15)cm^(-3). More importantly, even higher quality HgCdSe materials on GaSb are expected by further optimizing the growth conditions, using higher purity Se source material, and implementing postgrowth thermal annealing and defect/impurity gettering/filtering. Our results demonstrate the great potential of HgCdSe infrared materials grown on GaSb substrates for fabricating next generation infrared detectors with features of lower cost and larger array format size. | Z K Zhang W W Pan J L Liu W Lei | 2019 | Chinese Physics B2019，28，1： | 2 |
| 3 | EYA4、GRHL2和DFNA5基因多态性与中国人群噪声性听力损失的关联-一项病例对照研究显示文摘噪声性听力损失(NIHL)是由环境因素和遗传因素共同作用导致的疾病。动物实验已经证实,遗传因素会导致NIHL的发生,人群研究中也已经发现相关的易感基因。考虑到EYA4、GRHL2和DFNA5基因在人耳听觉系统中发挥重要的作用,研究者假设这些基因的多态性可能与NIHL的发生有关。 | Zhang X Yi L Lei Z 徐相蓉 | 2017 | 中华预防医学杂志2017，51，2： | 2 |
| 4 | Estimation of directions of arrival of multipath signal in CDMA systems 显示文摘 | Lei Z Lim T J | 2000 | IEEE Trans Commu2000，48，6： | 2 |
| 5 | Application of an intelligent classification method to mechanical fault diagnosis显示文摘 | LEI Y G HE Z J ZI Y Y | 2009 | Expert Systems with Applications2009，36，6： | 1 |
| 6 | QSAR study on N-containing corrosion inhibitors:Quantum chemical approach assisted by topological index显示文摘 | S G Zhang W Lei M Z Xia | 2005 | Journal of Molecular Structure:THEOCHEM2005，732，： | 1 |
| 7 | Ligation of TLR2 and TLR4 on murine bone marrow-derived mesenchymal stem cells triggers differential effects on their immunosuppressive activity显示文摘 | Lei J Wang Z Hui D | 2011 | Cell Immunol2011，271，1： | 1 |
| 8 | An application of Raman spectroscopy on the measurement of residual stress in porous silicon 显示文摘 | Kang Y L Qiu Y Lei Z K | 2005 | Optics and Lasers in Engineering2005，43，8： | 1 |
| 9 | Electricity production during the treatment of real electroplating wastewater containing Cr (VI) using microbial fuel cell 显示文摘 | Li Z Zhang X and Lei L | 2008 | Process Biochemistry2008，43，12： | 1 |
| 10 | Operator controlled device-to-device communications in LTE-advanced networks显示文摘 | LEI L ZHONG Z D LIN C | 2012 | IEEE Wireless Communications2012，19，3： | 1 |
| 11 | Implication of boron isotope geochemistry for the pedogenic environments in loess and paleosol sequences of central China显示文摘 | Wei H Z Lei F Jiang S Y Lu H Y Xiao Y K Zhang H Z Sun X F | 2015 | Quatern Res2015，83，1： | 1 |
| 12 | Root-microbe communication through protein secretion显示文摘 | De-la-Pea C Lei Z T Watson B S | 2008 | J Biol Chem2008，283，25： | 1 |
| 13 | Identification of molecularsubtypes of gastric cancer with different responses toPI3-kinase inhibitors and 5 -fluorouracil 显示文摘 | Lei Z Tan IB Das K | 2013 | Gastroen-terology2013，145，3： | 1 |
| 14 | Crack-tipamplification and shielding by micro-cracks inpiezoelectric solids-Part I: Static case 显示文摘 | LEI J WANG H Y ZHANG C Z | 2013 | EngineeringAnalysis with Boundary Elements2013，37，12： | 1 |
| 15 | Controlled synthesis of Pt/CS/PW12-GNs composite as an anodic electrocatalyst for direct methanol fuel ceils 显示文摘 | LI Z LEI F YE L | 2015 | Journal of Nanoparticle Ryeesearch2015，17，4： | 1 |
| 16 | Managing major chemical accidents in China: Towards effective risk information显示文摘 | HE G LEI Z LU Y | 2011 | Journal of Hazardous Materials2011，187，13： | 1 |
| 17 | Association between PCR-RFLP Polymorphisms of Five Gene Loci and Milk Traits in Chinese Holstein显示文摘 | Zhang R F Chen H Lei C Z | 2007 | Asian-Aust J Anim Sei2007，20，2： | 1 |
| 18 | Beneficial effects of fructose1,6-diphosphateo hemorrhagic shock in rats显示文摘 | Wang P Lei Z | 1999 | Chin J Traumatol1999，2，1： | 1 |
| 19 | Charaterization and flocculating properties of a novel bioflocculant produced by Bacillus circulans显示文摘 | Li Z Chen RW Lei HY | 2009 | World J Microbiol Biotechnol2009，25，： | 1 |
| 20 | Conducting polyaniline-coated silica nanoparticles by in situ chemical oxidative grafting polymerization显示文摘 | Lei X P Su Z X | 2007 | Polym Adv Techn2007，18，： | 1 |
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