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| 1 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 2 | Distribution patterns of tree species in a Malaysian tropical rain forest显示文摘 | He F Legendre P La Frankie J V | 1997 | Journal of Vegetation Science1997，8，： | 1 |
| 3 | yon Willebrand factor C1 C2 domain is involved in platelet adhesion to polymerized fibrin at high shear rate显示文摘 | KEUREN J F BARUCH D LEGENDRE P | 2004 | Blood2004，103，5： | 1 |
| 4 | Food web mediated export of biogenic carbon in oceans: hydrodynamic control 显示文摘 | LEGENDRE L RASSOULZADEGAN F | 1996 | Marine EcologyProgressive Series1996，145，： | 1 |
| 5 | Distribution patterns of tree species in a Malaysian tropical rain forest 显示文摘 | He F L Legendre P LaFrankie J V | 1997 | Journal of Vegetation Science1997，8，： | 1 |
| 6 | Depolymerization Reaction of Cis-polyisprene and Scrap Rubber in Supercritical Toluene 显示文摘 | Dhawan J C Bencsath A F Legendre R C | 1993 | Supercritical Fluids Engineering Science1993，514，： | 1 |
| 7 | Role of interleukin 6 (IL-6)/IL- 6R-induced signal tranducers and activators of transcription and mitogen activated protein kinase/ex tracellular显示文摘 | Legendre F Bogdanowicz P Boumediene K Pujol J P | 2005 | J Rheumatol2005，32，： | 1 |
| 8 | Distribution patterns of tree species in a Malaysian tropical rain forest 显示文摘 | He F L Legendre P LaFrankie J V | 1997 | Journal of Vegetation Science1997，8，： | 1 |
| 9 | Characterization of the oligogalacturonide - included oxidative burst in cultured soybean (Glycine max) cells显示文摘 | Legendre L Reuter S Heinstein P F | 1993 | Plant Phsiol1993，102，： | 1 |
| 10 | The phylogeny of termites(Dietyoptera: Isoptera) based on mitochondrial and nuclear markers: Implications for the evolution of the worker and pseudergate castes, and foraging behaviors显示文摘 | Legendre F Whiting M F Bordereau C | 2008 | Mol Phylogenet Evol2008，48，2： | 1 |
| 11 | Role of interleukin 6(IL-6)/ IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase显示文摘 | Legendre F Bogdanowicz P Boumediene K | 2005 | Rheumatol2005，32，7： | 1 |
| 12 | Rhein, the metab olite of diacerhein, reduces the proliferation of osteoarthritic ehondrocytes and synoviocytes without inducing apoptosis显示文摘 | Legendre F Heuze A Boukerrouche K | 2009 | Scand J Rheumatol2009，38，2： | 1 |
| 13 | Statistical significance of the matrix correlation coefficient for comparing independent phylogenetics trees 显示文摘 | LAPOINTE F J LEGENDRE P | 1992 | Systematic Biology1992，41，3： | 1 |
| 14 | Distribution pat-terns of tree species in a Malaysian tropical rain for-est显示文摘 | He F Legendre P La Frankie J V | 1997 | Journal of Vegetation Science1997，8，： | 1 |
| 15 | Micro- Encapsulation and Antifouling Coatings : Development of Poly ( lactic acid) Microspheres Containing Bioactive Molecules显示文摘 | Fay F Linossier I Legendre G | 2008 | Macromal Symp2008，272，1： | 1 |
| 16 | Distribution Panerns of Tree Species in a Malaysian Tropical Rain Forest 显示文摘 | HE F LEGENDRE P LAFRANKIE J V | 1997 | Journal of Vegetation Science1997，8，1： | 1 |
| 17 | primary phases and natural weathering of old lead-zinc pyrometallurgical slag from Príbram,Czech Republic显示文摘 | ETTLER V LEGENDRE O BODENAN F TOURAY J C | | 0，，03： | 1 |
| 18 | Depolymerization reactions of cis-polyisoprene and scrap rubber in supercritical toluene显示文摘 | Dhawan J C Bencsath A F Legendre R C | 1992 | Supercritical Fluids Engineering Science1992，514，30： | 1 |
| 19 | Distribution patterns of tree species in a Malaysian tropical rain forest显示文摘 | HE F L LEGENDRE P LAFRANKIE J | 1997 | Journal of Vegetation Science1997，8，： | 1 |
| 20 | On species-area relations显示文摘 | He F Legendre P | 1996 | The American Naturalist1996，148，： | 1 |
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