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| 1 | Galectin-1-mediated biochemical controls of melanoma and glioma aggressive behavior显示文摘Gliomas and melanomas are associated with dismal prognosis because of their marked intrinsic resistance to proapoptotic stimuli,such as conventional chemotherapy and radiotherapy,as well as their ability to escape immune cell attacks.In addition,gliomas and melanomas display pronounced neoangiogenesis.Galectin-1 is a hypoxia-sensitive protein,which is abundantly secreted by glioma and melanoma cells,which displays marked proangiogenic effects.It also provides immune tolerogenic environments to melanoma and glioma cells through the killing of activated T cells that attack these tumor cells.Galectin-1 protects glioma and melanoma cells against cytotoxic insults(including chemotherapy and radiotherapy) through a direct role in the unfolded protein response.Altogether,these facts clearly point to galectin-1 as an important target to be combated in gliomas and melanomas in order to:(1) weaken the defenses of these two types of cancers against radiotherapy,chemotherapy and immunotherapy/vaccine therapy;and(2) reinforce antiangiogenic therapies.In the present article,we review the biochemical and molecular biology-related pathways controlled by galectin-1,which are actually beneficial for melanoma and glioma cells,and therefore detrimental for melanoma and glioma patients. | Florence Lefranc Véronique Mathieu Robert Kiss | 2011 | World Journal of Biological Chemistry2011，2，9： | 6 |
| 2 | Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies显示文摘The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(VH)chain regions with ultralong third complementarity determining regions(CDR3)which,compared to other species,can provide a potent response to challenging antigens like HIV env.These unusual CDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding site.The genetic components and processes for forming these unusual cattle antibody VH CDR3 are not well understood.Here we analyze sequences of Bos taurus antibody VH domains and find that the subset with ultralong CDR3 exclusively uses a single variable gene,IGHV1-7(VHBUL)rearranged to the longest diversity gene,IGHD8-2.An eight nucleotide duplication at the 3′end of IGHV1-7 encodes a longer V-region producing an extended Fβ-strand that contributes to the stalk in a rearranged CDR3.A low amino acid variability was observed in CDR1 and CDR2,suggesting that antigen binding for this subset most likely only depends on the CDR3.Importantly a novel,potentially AID mediated,deletional diversification mechanism of the B.taurus VH ultralong CDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in place.These deletions serve to further diversify cysteine positions,and thus disulfide bonded loops.Hence,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle VH ultralong CDR3 repertoire. | Thaddeus C Deiss Melissa Vadnais Feng Wang Patricia L Chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F Criscitiello Vaughn V Smider | 2019 | Cellular & Molecular Immunology2019，16，1： | 4 |
| 3 | Differential expression of S100 calcium-binding proteins characterizes distinct clinical entities in both WHO grade Ⅱ and Ⅲ astrocytic tumours显示文摘 | Camby I Lefranc F Titeca G | 2000 | Neuropathol Appl Neurobiol2000，26，1： | 2 |
| 4 | Monitoring the expression profiles of integrins and adhesion/growth-regulatory galeetins in adamantinomatous craniopharyngiomas: their ability to regulate tumor adhesiveness to surrounding tissue and their contribution to prognosis 显示文摘 | Lefranc F Mijatovic T Decaestecker C | 2005 | Neurosurgery2005，56，4： | 1 |
| 5 | Characterisation and specificity of two single-chain Fv antibodies directed to the protein tyrosine kinase syk显示文摘 | Peneff C Lefranc MP Dariavach P | 2000 | J Immunol Meth2000，236，12： | 1 |
| 6 | Characterisation and specificity of two single-chain Fv antibodies directed to the protein tyrosine kinase Syk显示文摘 | Peneff C Lefranc MP Dariavach P | 2000 | J Immunol Meth2000，236，： | 1 |
| 7 | 查看详情显示文摘 | Mijatovic T De Nève N Bruyère C Simon G Dewelle J Van Quaquebeke E Van Der A.E Van Vynckt F Lefranc F Kiss R | | 0，，： | 1 |
| 8 | Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide显示文摘 | Robert R Lefranc MP Ghochikyan A | | 0，，01： | 1 |
| 9 | PAP IB, a new member of the Reg gene family: Cloning, expression, structural properties, and evolution by gene duplication显示文摘 | Emmanuelle Laurine Xavier Manival Claudine Montgelard Chantal Bideau Jean-Louis Bergé-Lefranc Monique érard Jean-Michel Verdier | 2005 | BBA - Gene Structure and Expression2005，，3： | 1 |
| 10 | Characterization of discriminant human brain antigenic targets in neuropsychiatric systemic lupus erythematosus using an immunoproteomic approach显示文摘 | Lefranc D Launay D Dubucquoi S | 2007 | Arthritis Rheum2007，56，10： | 1 |
| 11 | New insights into cell responses involved in experimental au toimmune encephalomyelitis and multiple sclerosis显示文摘 | El Behi M Dubucquoi S Lefranc D | 2005 | Immunol Lett2005，96，1： | 1 |
| 12 | Expression of members of the calcium-binding S-100 protein family in a rat model of cerebral basilar artery vasospasm显示文摘 | Lefranc F Golzarian J Chevalier C | 2002 | J Neurosurg2002，97，2： | 1 |
| 13 | Galectin-1:a small protein with major functions显示文摘 | Camby I Le Mercier M Lefranc F | 2006 | Glycobiology2006，16，11： | 1 |
| 14 | Galectin-l: a small protein with major functions显示文摘 | Camby I Le MM Lefranc F | 2006 | Glyeobiology2006，16，11： | 1 |
| 15 | Present and potential future adjuvant issues in high- grade astrocytic glioma treatment显示文摘 | LEFRANC F RYNKOWSKI M DEWITYE O | 2009 | Adv Tech Stand Neurosurg2009，34，： | 1 |
| 16 | Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastornas 显示文摘 | LEFRANC F FACCHINI V KISS R | 2007 | Oncologist2007，12，12： | 1 |
| 17 | Reconstructing the duplication history of tandemly repeated genes 显示文摘 | ELEMENTO O GASCUEL O LEFRANC M P | 2002 | Mol Biol Evol2002，19，： | 1 |
| 18 | New antigenic candidates in multiple sclerosis : identification by serological proteome analysis 显示文摘 | Almeras L Lefranc D Drobecq H | 2004 | Proteomics2004，4，7： | 1 |
| 19 | Naphthalimides and azonafides as promising anti-cancer agents显示文摘 | Ingrassia L Lefranc F Kiss R | 2009 | Curr Med Chem2009，16，10： | 1 |
| 20 | Genetic diversity of small eukaryotes in lakes differing by their trophic status 显示文摘 | Lefranc M Th6not A Lepre C | 2005 | Applied and Environmental Microbiology2005，71，10： | 1 |
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