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| 1 | “双盲、安慰剂对照交叉设计研究植物药对于进食量、饱腹感、体重减轻及氧化应激的影响”的研究方案(英文)显示文摘背景:植物性治疗药物作为一种重要且尚未被完全开发的药用资源,可能有助于热量控制从而产生长期的减重功效。从藤黄果(Garcinia combogia Desr.)中提取的羟基柠檬酸可能通过影响与饱腹有关的神经通路而减少摄食量和减轻体重。方法与设计:本研究为双盲、安慰剂对照、交叉设计试验,共计划纳入48名超重或肥胖的健康受试者(体重指数25.0~39.9 kg/m^2,年龄50~70岁),研究两种剂量藤黄果来源的羟基柠檬酸对摄食量、饱腹感、体重减轻及氧化应激水平的影响。摄食量作为主要结局指标,根据受试者在测量日的早餐、午餐和晚餐的摄食量计算。与平行设计的研究相比,本研究所使用的受试者数量将大大减少。讨论:本研究选择藤黄果来源的羟基柠檬酸为研究对象是因为该药物能够安全地减少摄食量、减轻体重和降低氧化应激水平。我们将会在研究过程中探讨其可能的作用机制和安全指标。 | Stephen D.Anton Jonathan Shuster Christiaan Leeuwenburgh | 2011 | 中西医结合学报2011，9，11： | 2 |
| 2 | The COVID-19 pandemic and physical activity显示文摘The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and lifestyle.Although the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some people.Unfortunately,there is currently no effective treatment for this disease.Pre-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and mortality.The immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the brain.The cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article. | Jeffrey A.Woods Noah T.Hutchinson Scott K.Powers William O.Roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi Sun Li Li Ji | 2020 | Sports Medicine and Health Science2020，2，2： | 2 |
| 3 | The osteogenic effect of electrosprayed nanoscale collagen/ calcium phosphate coatings on titanium显示文摘 | de Jonge L T Leeuwenburgh S C G van den Beucken J J J P | 2010 | Bioma?terials2010，31，9： | 1 |
| 4 | Barrett’s Esophagus and Esophageal Adenocarcinoma Are Common After Treatment for Achalasia显示文摘 | I. Leeuwenburgh P. Scholten T. J. Caljé R. J. Vaessen H. W. Tilanus B. E. Hansen E. J. Kuipers | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 5 | Radical scavenging and reducing ability of tilapia ( Oreochromis niloticus ) protein hydrolysates 显示文摘 | Raghavan S Kristinsson H G Leeuwenburgh C | 2008 | Journal of Agricultural and Food Chemistry2008，56，10： | 1 |
| 6 | Oxidative Stress and Antioxidants in Exercise显示文摘 | Leeuwenburgh C Heinecke J W | 2001 | Current Medicinal Chemistry2001，8，7： | 1 |
| 7 | Oxidative stress and antioxidants in exercise显示文摘 | Leeuwenburgh C Heinecke JW | 2001 | Curr Med Chem2001，8，7： | 1 |
| 8 | Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific显示文摘 | Leeuwenburgh C J Hollander R Ji L L | 1997 | Am J Physiol1997，272，： | 1 |
| 9 | Critical role of autophage in ischemia/reperfusion injury to aged livers显示文摘 | Wang JH Behrns KE Leeuwenburgh C | 2012 | Autophagy2012，8，1： | 1 |
| 10 | Apoptosis and exer- cise显示文摘 | Phaneuf S Leeuwenburgh C | 2001 | Med SciSportsExerc2001，33，3： | 1 |
| 11 | Isotope Dilution Mass Spectrometric Quantification of 3-Nitrotyrosine in Proteins and Tissues is Facilitated by Reduction to 3-Aminotyrosine显示文摘 | Crowley J R Yarasheski K Leeuwenburgh C | 1998 | Anal Biochem1998，259，： | 1 |
| 12 | Molecular inflammation: Underpinnings of aging and age-related diseases显示文摘 | Hae Young Chung Matteo Cesari Stephen Anton Emanuele Marzetti Silvia Giovannini Arnold Young Seo Christy Carter Byung Pal Yu Christiaan Leeuwenburgh | 2008 | Ageing Research Reviews2008，，1： | 1 |
| 13 | Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review 显示文摘 | Powers SK Ji LL Leeuwenburgh C | 1999 | Med Sci Sports Exerc1999，31，7： | 1 |
| 14 | Apoptosis and exercise 显示文摘 | Phaneuf S Leeuwenburgh C | 2001 | Med Sci Sports Exerc2001，3，： | 1 |
| 15 | In vitro degra- dation rate of apatitie calcium phosphate cement with incorporated PLGA micrnspheres 显示文摘 | Felix Lanao RP Leeuwenburgh SC Wolke JG | 2011 | Acta Biomaterialia2011，7，9： | 1 |
| 16 | Apoptosis in skeletal muscle with ag- ing显示文摘 | Dirks A Leeuwenburgh C | 2002 | Am J Physiol-Reg I2002，282，2： | 1 |
| 17 | Exercise training-induced alterations in skeletal muscle antioxidant capacity:a brief review 显示文摘 | Powers S K Ji L L Leeuwenburgh C | 1999 | Medicine and Science in Sports and Exercise1999，31，7： | 1 |
| 18 | Frailty syndromeand skeletal muscle: results from the Invecchiare in Chianti study显示文摘 | Cesari M Leeuwenburgh C Lauretani F | 2006 | Am J ClinNutr2006，83，5： | 1 |
| 19 | In vitro degradation rate of apatitic calcium phosphate ce- ment with incorporated PLGA microspheres 显示文摘 | F61ix Lanao RP Leeuwenburgh SC Wolke JG | 2011 | Acta biomater2011，7，9： | 1 |
| 20 | The role of mitochondrial DNA mutations in aging and sarcopenia:implications for the mitochondrial vicious cycle theory of aging显示文摘 | Hiona A Leeuwenburgh C | 2008 | Exp Gerontol2008，43，1： | 1 |
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