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| 1 | Mouse models in liver cancer research:A review of current literature显示文摘Primary liver cancer remains one of the most lethal malignancies worldwide. Due to differences in prevalence of etiological factors the incidence of primary liver can-cer varies among the world, with a peak in East-Asia. As this disease is still lethal in most of the cases, research has to be done to improve our understanding of the disease, offering insights for possible treatment options. For this purpose, animal models are widely used, especially mouse models. In this review, we describe the different types of mouse models used in liver cancer research, with emphasis on genetically engineered mice used in this field. We focus on hepatocellular carcinoma (HCC), as this is by far the most common type of primary liver cancer, accounting for 70%-85% of cases. | Martijn WH Leenders Maarten W Nijkamp Inne HM Borel Rinkes | 2008 | World Journal of Gastroenterology2008，14，45： | 16 |
| 2 | miR-133 and miR-30 Regulate Connective Tissue Growth Factor: Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling显示文摘 | Rudy F. Duisters Anke J. Tijsen Blanche Schroen Joost J. Leenders Viola Lentink Ingeborg van der Made Veronica Herias Rick E. van Leeuwen Mark W. Schellings Paul Barenbrug Jos G. Maessen Stephane Heymans Yigal M. Pinto Esther E. Creemers | 2009 | Circulation Research2009，，： | 2 |
| 3 | DD3 PCA3 -based Molecular Urine Analysis for the Diagnosis of Prostate Cancer显示文摘 | Daphne Hessels Jacqueline M.T. Klein Gunnewiek Inge van Oort Herbert F.M. Karthaus Geert J.L. van Leenders Bianca van Balken Lambertus A. Kiemeney J.Alfred Witjes Jack A. Schalken | 2003 | European Urology2003，，1： | 2 |
| 4 | Cadherin switching in human prostate cancer progression显示文摘 | Tomita K Van B A Leenders G J | 2000 | Cancer Res2000，60，13： | 1 |
| 5 | Neuroinflammation in the pathophysiology of Parkinson’s disease:evidence from animal models to human in vivo studies with-PK11195PET显示文摘 | Bartels AL Leenders KL | 2007 | Mov Disord2007，22，13： | 1 |
| 6 | How does the hu- man brain deal with a spinal cord injury显示文摘 | Bruehlmeier M Dietz V Leenders KL | 1998 | Eur J Neurosci1998，10，39： | 1 |
| 7 | Supplier Development 显示文摘 | Leenders M R | 1966 | Journal of Purchasing1966，2，4： | 1 |
| 8 | Purchasing and Materials Management显示文摘 | Leenders Metal | 1980 | Harvard Business Review1980，，34： | 1 |
| 9 | Activated pro-tein C protects against myocardial ischemia/reperfusioninjury via inhibition of apoptosis and inflammation显示文摘 | Loubele ST Spek CA Leenders P | 2009 | Arterioscler Thromb Vasc Biol2009，29，7： | 1 |
| 10 | The application of three-dimensional contrast-enhanced ultrasound to measure volume of affected tissue after HIFU treatment for localized prostate cancer 显示文摘 | Sedelaar JP Aarnink RG van Leenders GJ | 2000 | Eur Urol2000，37，5： | 1 |
| 11 | Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barri- er显示文摘 | Wu LJ Leenders AG Cooperman S | 2004 | BrainRes2004，1001，： | 1 |
| 12 | Liposomal amphotericin B( AmBisome) compared with amphotericin B both followed by oral fluconazole in the treatment of AIDS-associated cryptococcal meningitis显示文摘 | Leenders A Reiss P Portegies P | 1997 | AIDS1997，11，： | 1 |
| 13 | The effectiveness of different mechanisms for integrating marketing and R&D 显示文摘 | LEENDERS M A A M WIERENGA B | 2001 | Journal of Product Innovation Management2001，，19： | 1 |
| 14 | Prostate-specific antigen-based prostate cancer screening:reduction of prostate cancer mortality after correction for nonattendance and contamination in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer显示文摘 | Bokhorst L P Bangma C H van Leenders G J | 2014 | Eur Urol2014，65，2： | 1 |
| 15 | Team polarity and creative performance in innovation teams显示文摘 | Kratzer J Leenders R Van Engelen J | 2006 | Crea- tivity and Innovation Management2006，15，1： | 1 |
| 16 | The social structure of leadership and creativity in engineering de- sign teams: An empirical analysis显示文摘 | Kratzer J Leenders R J Van Engelen J L | 2008 | Journal of Engi- neering and Technology Management2008，25，4： | 1 |
| 17 | Impaired somatosensory discrimination of shape in Parkinson's disease: Association with caudate nucleus dopaminergic function 显示文摘 | WEDER B J LEENDERS K L VONTOBEL P | 1999 | Human Brain Mapping1999，8，： | 1 |
| 18 | Parkinson’s disease:The syndrome,thepathogenesis and pathophysiology显示文摘 | Bartels AL Leenders KL | 2009 | Cortex2009，45，： | 1 |
| 19 | Reward mechanisms in the brain and their role in dependence;evidence from neurophysiological and neuroimaging studies显示文摘 | MARTIN-SOELCH C LEENDERS K L CHEVALLEY A F | 2001 | Brain Research Reviews2001，36，2： | 1 |
| 20 | Cadherin switching in human prostate cancer progression 显示文摘 | Tomita K Bokhoven A Leenders GJ | 2000 | Cancer Res2000，60，13： | 1 |
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