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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Cesarean scar defect: correlation between Cesarean section number, defect size, clinical symptoms and uterine position 显示文摘 | Wang CB Chiu WW Lee CY | 2009 | Ultrasound Obstet Gyneeol2009，34，： | 1 |
| 3 | Association of Tyr phosphorylation of GIPase-activating protein with mitogenic action of serotonin显示文摘 | Lee SL Wang WW Fanburg BL | 1997 | Am J Physiol1997，272，11： | 1 |
| 4 | Evaluation of immediate poststress wall motion on adenosine stress/rest thallium-201 gated myocardial SPECT显示文摘 | Lee WW Park EK Eo JS | 2006 | Int J Cardiovasc Imaging2006，22，2： | 1 |
| 5 | Dysregulated balance of Th17 and Thl cells in systemic lupus erythematosus显示文摘 | Shah K Lee WW Lee SH | 2010 | Arthritis Res Ther2010，12，： | 1 |
| 6 | Reactive oxygen species-dependent EndoG release mediates cisplatin-induced caspase-independent apoptosis in human head and neck squamous carcinoma cells 显示文摘 | Kim JS Lee JH Jeong WW | 2008 | Int J Cancer2008，122，3： | 1 |
| 7 | Endothelin-1 stimulates the release of preloaded D-aspartate from cultured cerebellar granule cells显示文摘 | Lin WW Lee CY Chuang DM | 1990 | Biochem Biophts Res Commun1990，167，： | 1 |
| 8 | Occupational hazards and pregnancy outcomes显示文摘 | Zhang J Cai WW Lee DJ | 1992 | Am J Ind Med1992，21，3： | 1 |
| 9 | Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs显示文摘 | Lee SL Huang WJ Lin WW | 2005 | Bioorg Med Chem2005，13，22： | 1 |
| 10 | Stable Aqueous Based Cu Nanoparticie Ink for Printing Well-Defined Highly Conductive Features on a Plastic Substrate显示文摘 | Jeong S Song HC Lee WW | 2011 | Langmuir2011，27，： | 1 |
| 11 | High prevalence of HCV in a cohort of injectors on methadone-substitution treatment显示文摘 | Lee KC Lim WW Lee SS | 2008 | JClin Virol2008，41，4： | 1 |
| 12 | Shoulder function after thoracic surgery 显示文摘 | Li WW Lee TW Yim AP | 2004 | Thorac Surg Clin2004，14，3： | 1 |
| 13 | FDG uptake, glucose transporter type 1, and Ki-67 expressions in non-small-cell lung cancer: correlations and prognostic values 显示文摘 | Nguyen XC Lee WW Chung JH | 2007 | Eur J Radiol2007，62，： | 1 |
| 14 | Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer显示文摘 | Lee SJ Lee WW Yoon HJ | 2013 | Eur J Radiol2013，82，6： | 1 |
| 15 | Development of the 12-item Cross-Cultural Smell Identification Test (CC-SIT)显示文摘 | Doty RL Marcus A Lee WW | 1996 | Laryngoscope1996，106，3： | 1 |
| 16 | Regulatorymechanisms controlling human E-cad gene expression显示文摘 | Liu YN Lee WW Wang CY | 2005 | Oncogene2005，24，56： | 1 |
| 17 | A new species of Dasyhelea midge reared from Drain in Singapor (Diptera:Ceratopogonidae)显示文摘 | Lee KM WW Wirth and KL Chan | 1989 | Proc Ent Soc Wash1989，91，3： | 1 |
| 18 | The impact of thoracal access on early shoulder function: video- assisted thoracic surgery versus posterolateral thoracotomy 显示文摘 | Li WW Lee RL Lee TW | 2003 | European Journal of Cardio- thoracic Surgery2003，23，3： | 1 |
| 19 | Clinlcal rele- vance of dissolution testing in quality by design 显示文摘 | DICKINSON PA LEE WW STOTT PW | 2008 | AAPS J2008，10，2： | 1 |
| 20 | Cesarean scar defect:correlation between Cesarean section number, defect size,clinical symptoms and uterine position显示文摘 | Wang CB Chiu WW Lee CY | 2009 | Ultrasound ObstetGynecol2009，34，1： | 1 |
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