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| 1 | 台风伤害及其影响因素的现场流行病学研究显示文摘目的分析台风伤害的危险因素。方法采用现场流行病学调查方法,1:2配对的病例对照研究。对照组选伤害者邻居,按照同职业、同村庄、同性别和年龄±5岁配对。结果台风造成392人受伤住院治疗,50人死亡。伤害罹患率为27.3/10万,伤害致死率为11.3%,伤害死亡率3.1/10万。调查了209名受伤者和31名死亡者。发现伤害主要发生在台风来临前,其中台风来临前1~6小时之间有病例155例,占64.6%。209例伤害病例中,67.5%的病例曾得到过台风预警,但138名应答者中重视预警的只有47人,仅占34.0%。发现“台风来临时不在家中”[调整OR值(MH)=3.9 (95%CI:1.9~7.7)]、“台风来临前未得到预警”[调整OR值(MH)=3.3(95%CI:1.3~8.6)]和“虽得到预警但不重视”[调整OR值(MH)=17(95%CI:4.2~68)]是台风伤害的危险因素。结论外出、不重视预警是台风伤害的危险因素,应加强台风来临的预警宣传力度。 | 龚震宇 柴程良 屠春雨 林君芬 高奕 邱银伟 曾光 Robert E.Fontaine Lee CK 何凡 陈坤 | 2006 | 中华流行病学杂志2006，27，9： | 10 |
| 2 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 3 | A comparison of postoperative complications in open versus robotic cystectomy显示文摘 | Ng CK Kauffman EC Lee MM | 2010 | European Urology2010，，02： | 2 |
| 4 | Gene expression profile of aging and its retardation by caloric restriction显示文摘 | Lee CK Klopp RG Weindruch R | 1999 | Science1999，285，5432： | 1 |
| 5 | Endotoxin increases hepatic susceptibility to lipid peroxidafion: a possible role of iron 显示文摘 | Ibrahim W Lee US Chow CK | 2004 | Biochem Mol Toxicol2004，18，1： | 1 |
| 6 | Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up 显示文摘 | Lee HW Jung DK Suh CK | 2006 | Epilepsy Behav2006，8，： | 1 |
| 7 | Expression of vascular endothelial growth factor and inducible nitric oxide synthase in pterygia显示文摘 | Lee DH Cho H J Kim JT Choi JS Joo CK | 2001 | Cornea2001，20，7： | 1 |
| 8 | Oral immunization with recombinant helicobacter pylori urease induces secretory LgA antibodies and protects mice from challenge with helicobacter felis显示文摘 | Lee CK Weltzin R Thomas WD | 1995 | J Infeet Dis1995，173，： | 1 |
| 9 | The role of virus specific CD8+ cells in liver damage and viral control during persistent hepatitis B virus infection 显示文摘 | Maini MK Boni C Lee CK | 2000 | J Experimental Medicine2000，191，8： | 1 |
| 10 | Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesis显示文摘 | Suk S Lee CK Kim WJ | 1997 | Spine1997，22，2： | 1 |
| 11 | Comparison of Zielke ventral derotation system and Cotrel-Dubousset instrumentation in the treatment of idiopathic lumbar and thoracolumbar scoliosis显示文摘 | Suk SII Lee CK Chung SS | 1994 | Spine1994，19，： | 1 |
| 12 | Impact of E2F-1 expres-sion on clinical outcome of gastric adenocarcinoma pa-tients with adjuvant chemoradiation therapy显示文摘 | Lee J Park CK Park JO | 2008 | Clin CanRes2008，14，1： | 1 |
| 13 | Hepatitis B virus infection:current status显示文摘 | Ocama P Opio CK Lee WM | 2005 | Am J Med2005，118，12： | 1 |
| 14 | A comparison of angled sagittal MRI and conventional MRI in the diagnosis of herniated disc and stenosis in the cervical foramen显示文摘 | Shim JH Park CK Lee JH | 2009 | Eur Spine J2009，18，8： | 1 |
| 15 | Hepatitis B virus X protein induces the expression of MTAI and HDACl, which enhances hypoxia signaling in hepatocellular carcinoma cells 显示文摘 | Yoo YG Na TY Seo HW Seong JK Park CK Shin YK Lee MO | 2008 | Oncogene2008，27，24： | 1 |
| 16 | Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesis显示文摘 | Suk SI Lee CK Kim WJ | 1997 | spine1997，22，2： | 1 |
| 17 | Gastrodia elata blume and an active component,p-Hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions显示文摘 | Yu SJ Kim JR Lee CK | 2005 | Biol Pharm Bull2005，28，6： | 1 |
| 18 | Osteoconduction at porous hydroxyapatite with various pore configurations显示文摘 | Chang BS Lee CK Hong KS | | 0，，12： | 1 |
| 19 | Minimally invasive transforaminal lumbar interbody fusion using a single interbody cage and a tubular retraction system:technical tips,and perioperative,radiologic and clinical outcomes显示文摘 | Lee CK Park JY Zhang HY | 2010 | Korean Neurosurg Soc2010，48，3： | 1 |
| 20 | AZD9291, a mutant- selective EGFR inhibitor, as first-line treatment for EGFR mutation-positive advanced non-small cell lung cancer (NSCLC) :Results from a phase 1 expansion cohort显示文摘 | Ramalingam SS Yang JC Lee CK | 2015 | J Clin Oncol2015，33，15： | 1 |
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