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| 1 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 2 | Non- dissociative electron capture by disulfide bonds 显示文摘 | Caries S Lecomte F Schermann J P | 2001 | J Phys Chem A2001，105，23： | 1 |
| 3 | An analytical model for the prediction of load distribution in multi-bolt composite joints including hole-location errors 显示文摘 | LECOMTE J BOIS C WARGNIER H | 2014 | Composite Structures2014，117，： | 1 |
| 4 | Chemo-enzymatie functionalization of gallic and vaninie acids:Synthesis of bio-based epoxy rosins prepolymem显示文摘 | AOUF C LECOMTE J VILLENEUVE P | 2012 | Green Chemistry2012，14，8： | 1 |
| 5 | Using a spatial and stage-structured invasion model to assess the spread of feral populations of transgenic oilseed rape显示文摘 | GAMIER A LECOMTE J | 2006 | Ecological Modeling2006，194，： | 1 |
| 6 | Identification of a new group of bovine viral diarrhea virus strains associated with severe outbreaks and high mortalities 显示文摘 | Pellerin C van den Hurk J Lecomte J | 1994 | Virology1994，203，： | 1 |
| 7 | Indentification of a new group of bovine viral diarrhea virus strains associated with sever outbreaks and gigh mortalities显示文摘 | Pellerin C Van Den Hurk I Lecomte J | 1994 | Virology1994，203，： | 1 |
| 8 | Prognostic factors for patients with small cell lung carcinoma:analysis of a serics of 763 patients included in 4 consecutive prospective trials with a minimum follow-up of 5 years显示文摘 | Paesmans M Sculier JP Lecomte J | | 0，，： | 1 |
| 9 | Ploymer blends used for the aqueous coating of solid dosage forms:importance of the type of plasticizer显示文摘 | Lecomte F Siepmann J Walther M | 2004 | J Control Release2004，99，1： | 1 |
| 10 | Genomewide expression profiling of the host response to root-knot nematode infection in Arabidopsis显示文摘 | Jammes F Lecomte P de Almeida-Engler J | 2005 | Plant Journal2005，44，3： | 1 |
| 11 | The Traceability in the Agricultural and Food Industry: Stakes, Marks Bench 显示文摘 | LECOMTE C NAJAR L NEFUSSI J | 2003 | Industries Alimentaires et Agricoles2003，120，5： | 1 |
| 12 | Hierarchical and conditional combination of belief functions induced by visual tracking显示文摘 | Klein J Lecomte C Miche P | 2010 | International Journal of Approximate Reasoning2010，51，4： | 1 |
| 13 | Thixoforging of 7075 aluminum alloys at high solid fraction 显示文摘 | G Vaneetveld A Rassili J Lecomte | 2006 | Solid State Phenomena2006，，： | 1 |
| 14 | Living with uncertainty genetic imprints of climate shrifts in East Pacific anchovy (Engraulis mordax) and sardine ( Sardinops sagax) 显示文摘 | Lecomte F Grant W S Dodson J J | 2004 | Molecular Ecology2004，13，8： | 1 |
| 15 | Pharmacological properties of acetorphan,a parenterally active enkephalinase inhibitor显示文摘 | Lecomte JM Costentin J Vlaicuiescu A | 1986 | J Pharmacol Exp Ther1986，237，： | 1 |
| 16 | Protection from mouse hepatitis virus type 3-induced acute disease by an anti-nucleoprotein monoclonal antibody显示文摘 | Lecomte J Cainelli Gebara V Mercier G | 1987 | Arch Virol1987，97，12： | 1 |
| 17 | Prognostic factors for patients with small cell lung carcinoma: analysis of a series of 763 patients included in 4 consecutive prospective trials with a minimum forllow-up of 5 years显示文摘 | Paesmans M Scttlier JP Lecomte J | 2000 | Cancer2000，89，3： | 1 |
| 18 | Behavior of hexavalent chromium in a polluted groundwater: Redox processes and immobilization in soils 显示文摘 | LOYAUX-LAWNICZAK S LECOMTE P EHRHARDT J J | 2001 | Environmental Science and Technology2001，35，7： | 1 |
| 19 | Tight perioperative glucose control is associated with a reduction in renal impairment and renal failure in non-diabetic cardiac surgical patients显示文摘 | Lecomte P Van Vlem B Coddens J | 2008 | Crit Care2008，12，6： | 1 |
| 20 | Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice显示文摘 | Lambert V Lecomte J Hansen S | 2013 | Nat Protoc2013，8，： | 1 |
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