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| 1 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 2 | Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients显示文摘 | Ouattara A Lecomte P Le Manach Y | 2005 | Anesthesiology2005，103，4： | 1 |
| 3 | Using a spatial and stage-structured invasion model to assess the spread of feral populations of transgenic oilseed rape显示文摘 | GAMIER A LECOMTE J | 2006 | Ecological Modeling2006，194，： | 1 |
| 4 | Iron Based Flame Retarding/Smoke Suppressing Compounds for PVC 显示文摘 | Lecomte L Bert M Michel A Guyot A | 1977 | JMacromol Sci-Chem1977，11，： | 1 |
| 5 | Thixoforging of 7075 aluminum alloys at high solid fraction 显示文摘 | G Vaneetveld A Rassili J Lecomte | 2006 | Solid State Phenomena2006，，： | 1 |
| 6 | Pharmacological properties of acetorphan,a parenterally active enkephalinase inhibitor显示文摘 | Lecomte JM Costentin J Vlaicuiescu A | 1986 | J Pharmacol Exp Ther1986，237，： | 1 |
| 7 | Terlipressin may influence the outcome of hepatorenal syndrome complicating alcoholic hepatitis显示文摘 | Cervoni JP Lecomte T Cellier C Auroux J Simon C Landi B Gadano A Barbier JP | | 0，，： | 1 |
| 8 | Detectionof free - circulating tumor - associated DNA in plasma of colorectalcancer patients and its association with prognosis显示文摘 | LECOMTE T BERGER A ZINZINDOHOU^ F | 2002 | Int J Can-cer2002，100，5： | 1 |
| 9 | Poor intraoperative blood glucose conteol is associated with a worsened hospital outcome after cardiac surgery in diabetic patients 显示文摘 | Quattara A Lecomte P Le Manach Y | 2005 | Anesthesiology2005，103，4： | 1 |
| 10 | Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours 显示文摘 | FLEURY-FEITH J LECOMTE C RENIER A | 2003 | Oncogene2003，22，24： | 1 |
| 11 | Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients显示文摘 | Ouattara A Lecomte P Le Manach Y Landi M | | 0，，04： | 1 |
| 12 | He coronary and myocardial effects of remifentanil and sufentanil in the erythrocyte - perfused isolated rabbit heart显示文摘 | Lecomte P Quattara A Le Manach Y | 2006 | Anest h Analg2006，103，： | 1 |
| 13 | Life cycle assessment (LCA) applied to tile design of an innovative drying process for sewage sludge 显示文摘 | Peregrina C A Lecomte D Arlabosse P | 2006 | Process Safety and Environmental Protection2006，84，4： | 1 |
| 14 | Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients显示文摘 | Ouattara A Lecomte P Le Manach Y | 2005 | Anesthesiology2005，103，4： | 1 |
| 15 | Effective thermal conductivity of divided silica xerogel beds显示文摘 | BISSON A RIGACCI A LECOMTE D | 2004 | Journal of NonCrystalline Solids2004，350，： | 1 |
| 16 | Kinetic Study of the Isomerization of Glucose into Fructose in the Presence of Anion-modified Hydrotalcites 显示文摘 | LECOMTE J FINIELS A MOREAU C | 2002 | Starch - Starke2002，，54： | 1 |
| 17 | The coronary and myocardial effects of remifentanil and sufentanil in the erythrocyteperfused isolated rabbit heart显示文摘 | Lecomte P Ouattara A Le Manach Y | 2006 | Anesth Analg2006，103，1： | 1 |
| 18 | Mineral weathering in semiarid mountain river: Its assessment through PHREEQC inverse modeling 显示文摘 | Lecomte K L Pasquini A I Depetris P J | 2005 | Aquatic Geochemistry2005，11，2： | 1 |
| 19 | X-ray reflectivity, diffraction and grazing incidence small angle X-ray scattering as complementary methods in the microstructural study of sol-gel zirconia thin films显示文摘 | Lenormand P Lecomte A Babonneau D | 2006 | Thin Solid Films2006，495，12： | 1 |
| 20 | Use of limestone sands and fillers in concrete without superplastieizer 显示文摘 | Joudi-Bahri I Lecomte A Ouezdou M B | 2012 | Cement and Concrete Composites2012，34，6： | 1 |
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