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| 1 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 2 | Cloning and mRNA expression of the Ca2+-binding DREAM protein in the pituitary显示文摘 | Leclerc G M Leclerc G J Shorte S L | 2002 | Gen Comp Endocrinol2002，129，1： | 1 |
| 3 | Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state 显示文摘 | Foretz M H6brard S Leclerc J | 2010 | J Clin Invest2010，120，： | 1 |
| 4 | Cryopreservation alters the levels of the bull sperm surface protein P25b显示文摘 | Parent S Leclerc P | 2000 | J Androl2000，21，5： | 1 |
| 5 | Novel aspects of calmodulin target recognition and activation显示文摘 | Vetter S W Leclerc E | 2003 | Eur J Biochem2003，270，3： | 1 |
| 6 | Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies 显示文摘 | Wan S LeClerc J L Vincent J L | 1997 | Chest1997，112，3： | 1 |
| 7 | Hepatic release of interleukin-10 during cardiopulmonary bypass in steroidpretreated patients显示文摘 | WAN S LECLERC J I SCHMART Z D | 1997 | Am Heart J1997，133，4： | 1 |
| 8 | Can generic paediatfic mortality scores calculated 4 hours after admission be used as inclusion criteria for clinical trials? 显示文摘 | Leteurtre S Leclerc F Wirth J | 2004 | Crit Care2004，8，4： | 1 |
| 9 | EEG spectral analysis in wakefulness, REM andNREM sleep following sport-related concussions 显示文摘 | Gosselin N’Lassonde M Petit D Leclerc S Mongrain V Mont-plaisir J | 2007 | Sleep2007，，： | 1 |
| 10 | Can generic scores(Pediatric Risk of Mortality and Pediatric Index of Mortality) replace specific scores in predicting the outcome of presumed meningococcal septic shock in children? 显示文摘 | Leteurtre S Leclerc F Martinot A | 2001 | Crit Care Med2001，29，6： | 1 |
| 11 | Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children显示文摘 | LECLERC F LETEURTRE S DUHAMEL A | 2005 | Am J Respir Crit Care Med2005，171，4： | 1 |
| 12 | Inhibition of Cyclin-dependent Kinases by Purine Ana?logues Crystal Structure of Human Cdk2 Complexed with Roscovitine显示文摘 | DE AZEVEDO W F LECLERC S MEIJER L | 1997 | EurJ Biochern1997，243，： | 1 |
| 13 | Minimally conjoined omphalopagi: a consistent spectrum of anomalies显示文摘 | Poenaru D Uroz-Tristan J Leclerc S | 1994 | J Pediatr Surg1994，29，9： | 1 |
| 14 | Investigation of MYST4 histone acetyltransferase and its involvement in mammalian gametogenesis显示文摘 | McGraw S Morin G Vigneault C Leclerc P Sirard M.A | | 0，，： | 1 |
| 15 | Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/ AMPK pathway via a decrease in hepatic energy state 显示文摘 | Foretz M Hebrard S Leclerc J | 2010 | J Clin Invest2010，120，7： | 1 |
| 16 | Attitudes toward death, dying, end-of-life palliative care, and interdisciplinary practice in long term care workers显示文摘 | Leclerc BS Lessard S Bechennec C | 2014 | J Am Med Dir Assoc2014，15，3： | 1 |
| 17 | Antihypertensive activity of casein-enriched milk fermented by Lactobacillus helveticus显示文摘 | Leclerc P L Gauthier S F Bachelard H | 2002 | International Dairy Journal2002，12，： | 1 |
| 18 | Synthesis and Electroluminescent Properties of High-Efficiency Saturated Red Emitter Based on Copolymers from Fluorene and 4,7-Di(4-hexylthien-2-yl)-2,1,3-benzothiadiazole显示文摘 | Beaupre S Leclerc M | 2002 | Adv Funct Mater2002，12，： | 1 |
| 19 | Inflammatory response to cardiopulmonary bypass:mechanisms involved and possible therapeutic strategies显示文摘 | Wan S LeClerc JL Vincent JL | 1997 | Chest1997，112，3： | 1 |
| 20 | Age and origin of Albi- an glauconites and associated clay minerals inferred from a de- tailed geochemical analysis 显示文摘 | Rousset D Leclerc S Clauer N | 2004 | Journal of Sedimentary Re- search2004，74，5： | 1 |
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