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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Handling multiple objectives with particle swarm optimization 显示文摘 | COELLO C AC PULIDO G T LECHUGA M S | 2004 | IEEE Transactions on Evolutionary Computation2004，8，3： | 1 |
| 3 | Real-time detection of chlorpyrifos at part per trillion levels in ground,surface and drinking water samples by a portable surface plasmon resonance immunosensor显示文摘 | Mauriz E Calle A Lechuga LM | | 0，，1： | 1 |
| 4 | A summary of European experience with shore nourishment显示文摘 | L Hamm M Capobianco H.H Dette A Lechuga R Spanhoff M.J.F Stive | 2002 | Coastal Engineering2002，，2： | 1 |
| 5 | Handling multiple objectives with particle swarm optimization显示文摘 | Coello C C A Pulido G T Lechuga M S | 2004 | IEEE Trans on Evolutionary Computations2004，8，3： | 1 |
| 6 | Age differences in memory control: Evi- dence from updating and retrieval practice tasks 显示文摘 | LECHUGA M T MORENO V PELEGRINA S | 2006 | Acta Psychological2006，123，： | 1 |
| 7 | Handling Multiple Objectives with Particle Swarm Optimization 显示文摘 | Coello C A C Pulido G T Lechuga M S | 2004 | IEEE Transactions on Evolutionary Computation (S1089-778X)2004，8，3： | 1 |
| 8 | Handling multiple objectives with particle swarm optimization 显示文摘 | Coello C A Pulido G T Lechuga M S | 2004 | IEEE Trans on Evolutionary Computation2004，8，3： | 1 |
| 9 | ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis 显示文摘 | Gonzalez-Mariscal L Bautista P Lechuga S | 2012 | Ann N Y Acad Sci2012，1257，： | 1 |
| 10 | Handling multiple objectives with particle swarm optimization显示文摘 | COELLO C A C PULIDO G T LECHUGA M S | 2004 | IEEE Trans on Evolutionary Computation2004，8，3： | 1 |
| 11 | Handling multiple objectives with particle swarm optimization 显示文摘 | Coello C A C Pulido G T Lechuga M S | 2004 | IEEE Transactions on Evolutionary Computation2004，8，： | 1 |
| 12 | Handling multiple objectives with particle swarm optimization显示文摘 | COELLO C PULIDO G LECHUGA M | 2004 | IEEE Transactions on Evolutionary Computation2004，8，3： | 1 |
| 13 | Handling Multiple Objectives with Particle Swarm Optirmzation 显示文摘 | COELLO C A PULIDO G T LECHUGA M S | 2004 | IEEE Transac- tions on Evolutionary Computation2004，8，3： | 1 |
| 14 | Handling multiple objectives with particle swarm optimization显示文摘 | Coello Coello CA Pulido G T Lechuga M S | 2004 | IEEE Transations on Evolutionary Computation2004，8，3： | 1 |
| 15 | Han- dling multiple objectives with particle swarmoptimization显示文摘 | COELLO COELLO C A PULIDO G T LECHUGA M S | 2004 | IEEETransactions on Evolutionary Computation2004，8，3： | 1 |
| 16 | Optimized silicon antiresonant reflecting optical waveguides for sensing application 显示文摘 | Prieto F Lechuga L M Calle A | 2001 | Journal of Lightwave Technology2001，19，： | 1 |
| 17 | Handling multiple objectives with particle swarm optimization显示文摘 | Coello C A C Pulido G T Lechuga M S | 2004 | IEEE Trans on Evolutionary Computation2004，8，3： | 1 |
| 18 | Handing multiple objectives with particle swarm optimization显示文摘 | Coello C C A Pulido G T Lechuga M S | 2004 | IEEE Transactions on Evolutionary Computation2004，8，3： | 1 |
| 19 | Handling multiple ob- jectives with particle swarm optimization 显示文摘 | Coello C A C Pulido G T Lechuga M S | 2004 | IEEE Transactions on Evolu- tionary Computation2004，8，3： | 1 |
| 20 | Handling multiple objectives with particle swarm optimization显示文摘 | COELLO COELLO CA PULIDO GT LECHUGA MS | | 0，，03： | 1 |
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