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| 1 | Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil显示文摘AIM To identify environmental risk factors associated with the development of Crohn's disease(CD) in order to reassess the hygiene hypothesis.METHODS A hospital-based, case-control study was carried out with CD patients(n = 145) and controls(n = 163)representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water(P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender(OR = 2.09), under age 40(OR = 3.10), white(OR = 2.32), from a small family in childhood(OR = 2.34) and adulthood(OR = 3.02), absence of viral infections in childhood(OR = 2.23), exposure to enteric pathogens(OR = 2.41), having had an appendectomy(OR = 2.47) and prior or current smoker(OR = 2.83/1.12). CONCLUSION Most variables supporting the 'hygiene hypothesis' are associated with the development of CD but are not independent predictors of the diagnosis. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 2 | Deacidification of grape juice with derepressed mutants of the yeast Hansenula anomala显示文摘 | CORTE-REAL M LEAO C | | 0，，05： | 1 |
| 3 | Growth and fermentation patterns of Sacharomyces cerevisiae under different ammonium concentrations and its implications in winemaking industry显示文摘 | Mendes-Ferreira A Mendes-Faia A Leao C | 2004 | Journal of Applied Microbiology2004，97，： | 1 |
| 4 | A Proposed Mechanism for Nitrate and Thiocyanate Elution of Strong-base Ion Exchange Resins Loaded with Copper and Gold Cyanocomplexes 显示文摘 | Oliveira A M Leao V A Silva C A da | 2008 | React Funct Polym2008，68，1： | 1 |
| 5 | Current trends of HIV disease of the mouth显示文摘 | Frezzini C Leao JC Porter S | 2005 | J Oral Pathol Med2005，34，9： | 1 |
| 6 | Deacidification of grape juice with derepressed mutants of the yeast Hansenula anomala显示文摘 | Corte-Real M Leao C | 1992 | Appl Microbiol Biotechno 11992，36，5： | 1 |
| 7 | Transport of malic acid and other decarboxylic acids in the Yeast Hansenula anomala显示文摘 | Corte-Real M Leao C | 1990 | Appl Envir Microb1990，56，4： | 1 |
| 8 | Transient and steady-state models for simulated moving bed processes: numerical solutions显示文摘 | Leao C P Rodrigues A E | 2004 | Computers and Chemical Engineering2004，28，： | 1 |
| 9 | Isolation and characterization of Ornithobaclerium rhinotracheale from chickens in Brazil显示文摘 | Canal C Leao W Rocha J A | 2005 | Research in Veterinary Science2005，78，3： | 1 |
| 10 | Status of research in stock enhancement and sea ranching显示文摘 | Liao I C Su M S Leao E M | 2003 | Reviews in Fish Biology and Fisheries2003，13，2： | 1 |
| 11 | Zeolite in the diet of beef cattle显示文摘 | Camara L R A Valadares Filho S C Leao M I etal | 2012 | Arquivo Brasileiro de Medieina Vet- erinaria e Zootecnia2012，64，3： | 1 |
| 12 | Isolation andcharacterization of Ornithobacterium rhinotracheale fromchickens in Brazil显示文摘 | Canal C W Leao J A Rocha S L S | 2005 | Research in Veterinary Science2005，35，2： | 1 |
| 13 | Inverse diauxy in the yeast Hansenula anomala: mutants derepressed for malic acid utilization in the presence of glucose显示文摘 | Corte-Real M Leao C Van Uden N | 1990 | Applied and Environmental Microbiology1990，56，11： | 1 |
| 14 | Growth and fermentation patterns of Saccharomyces cerevisiae under different ammonium concentrations and its implications in winemaking industry显示文摘 | Mendes-Ferreira A Mendes-Faia A Leao C | 2004 | Journal of Applied Microbiology2004，97，3： | 1 |
| 15 | Mycobacterium tuberculosis complex differentiation using gyrB-restriction fragment length polymorphism analysis显示文摘 | Chimara E Ferrazoli L Leao S C | 2004 | Mem Inst Oswaldo Cruz2004，99，7： | 1 |
| 16 | Deacidification of grape juice with dere-pressed mutants of the yeast Hnasenula anomala显示文摘 | CORTE-REAL M LEAO C | 1992 | J APP Micro andBiotechnol1992，36，5： | 1 |
| 17 | 显示文摘 | Leao C Van uder N | 1994 | Biochimica et Biophysica Acta1994，774，： | 1 |
| 18 | Deacidification of Grape Juice with Derepressed Mutants of the Yeast Hansenula anomala显示文摘 | Corte - Real M Leao C | 1992 | Appl Microbiol Biotechnol1992，36，5： | 1 |
| 19 | Transport of Malic Acid and Other Decarboxylic Acids in the Yeast Hansenula anomala显示文摘 | Corte- Real M Leao C | 1990 | Appl Envir Microb1990，56，4： | 1 |
| 20 | Characterization of mycobacteria from a major Brazilian outbreak suggests that revision of the taxonomic status of members of the Mycobacterium chelonae-M, abscessus group is needed 显示文摘 | Leao SC Tortoli E Viana-Niero C | 2009 | J Clin Microbiol2009，479，9： | 1 |
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