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| 1 | Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil显示文摘AIM To identify environmental risk factors associated with the development of Crohn's disease(CD) in order to reassess the hygiene hypothesis.METHODS A hospital-based, case-control study was carried out with CD patients(n = 145) and controls(n = 163)representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water(P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender(OR = 2.09), under age 40(OR = 3.10), white(OR = 2.32), from a small family in childhood(OR = 2.34) and adulthood(OR = 3.02), absence of viral infections in childhood(OR = 2.23), exposure to enteric pathogens(OR = 2.41), having had an appendectomy(OR = 2.47) and prior or current smoker(OR = 2.83/1.12). CONCLUSION Most variables supporting the 'hygiene hypothesis' are associated with the development of CD but are not independent predictors of the diagnosis. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 2 | Left Ventricle Failure and Blood Flow Estimation for Centrifugal Blood Pumps显示文摘 | Eduardo Guy Perpetuo Bock Tarcisio Leao Jeison Fonseca AronAndrade | 2016 | Journal of Mechanics Engineering and Automation2016，6，3： | 2 |
| 3 | Slurry sampling for the determination of mercury in rice using cold vapor atomic absorption spectrometry显示文摘 | Silva L O B da Silva D G Leao D J | 2012 | Food Analytical Methods2012，5，6： | 1 |
| 4 | Deacidification of grape juice with derepressed mutants of the yeast Hansenula anomala显示文摘 | CORTE-REAL M LEAO C | | 0，，05： | 1 |
| 5 | Growth and fermentation patterns of Sacharomyces cerevisiae under different ammonium concentrations and its implications in winemaking industry显示文摘 | Mendes-Ferreira A Mendes-Faia A Leao C | 2004 | Journal of Applied Microbiology2004，97，： | 1 |
| 6 | HCV infection: aspects of epidemiology and transmission relevant to oral health care workers显示文摘 | J.C. Leao C.G. Teo S.R. Porter | 2005 | International Journal of Oral & Maxillofacial Surgery2005，，4： | 1 |
| 7 | Peroxisome homeostasis in Hansenula polymorpha显示文摘 | Leao AN Kiel JAKW | 2003 | FEMS Yeast Res2003，4，： | 1 |
| 8 | Sarcoidosis-a clinically orientated review显示文摘 | Dastoori M Fedele S Leao JC | 2013 | J Oral Pathol Med2013，42，4： | 1 |
| 9 | A Proposed Mechanism for Nitrate and Thiocyanate Elution of Strong-base Ion Exchange Resins Loaded with Copper and Gold Cyanocomplexes 显示文摘 | Oliveira A M Leao V A Silva C A da | 2008 | React Funct Polym2008，68，1： | 1 |
| 10 | An appli- cation of capillary electrophoresis for the analysis of algal toxins from the aquatic environment显示文摘 | GAGO-MARTINEZ A LEAO J M PINEIRO N | 2003 | Intern J Environ Anal Chore2003，83，6： | 1 |
| 11 | Pial circulation and spreading depression of activity in the cerebral cortex 显示文摘 | Leao A A | 1944 | J Neurophysiology1944，7，： | 1 |
| 12 | The relationship between pcriodontitis and preteerm low birthweight 显示文摘 | Vettore M V Leal M Leao A T | 2008 | J Dent Res2008，87，1： | 1 |
| 13 | Spreading depression activity in the cerebral cortex显示文摘 | Leao APP | 1944 | J Neurophysiol1944，7，： | 1 |
| 14 | Spreading depression显示文摘 | Leao AA | 1986 | Funct Neurol1986，1，4： | 1 |
| 15 | Partial recording protocols for periodontal disease assessment in epidemiological surveys显示文摘 | Vettore MV Lamarca G de A Leao AT | 2007 | Cad Saude Publica2007，23，1： | 1 |
| 16 | Current trends of HIV disease of the mouth显示文摘 | Frezzini C Leao JC Porter S | 2005 | J Oral Pathol Med2005，34，9： | 1 |
| 17 | Deacidification of grape juice with derepressed mutants of the yeast Hansenula anomala显示文摘 | Corte-Real M Leao C | 1992 | Appl Microbiol Biotechno 11992，36，5： | 1 |
| 18 | Triptorelin every other day can prevent premature LH surge: a strategy to reduce the daily gonadotrophin-releasing hormone agonists injections显示文摘 | Cambiaghi AS Leao RBF Castellotti DS | 2011 | Fertil and Steril2011，96，3： | 1 |
| 19 | Relation between clinical dental status and subjective impacts on daily living显示文摘 | Leao A Sheiham A | 1995 | Dent Res1995，74，7： | 1 |
| 20 | Transport of malic acid and other decarboxylic acids in the Yeast Hansenula anomala显示文摘 | Corte-Real M Leao C | 1990 | Appl Envir Microb1990，56，4： | 1 |
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