|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 3 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 4 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 5 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 6 | ZSM-5 zeolite with enhanced acidic properties显示文摘 | Le Van Mao R Le T S Fairbain M Muntasar A Xiao S Denes G | | 0，，： | 2 |
| 7 | Decreased NURR1 gene expression in patients with Parkinson's disease显示文摘 | Le W Pan T Huang M | 2008 | J Neurol Sci2008，273，12： | 1 |
| 8 | Solid-State Materials for Advanced Technology, Materials Science and Engineering B显示文摘 | NGUYEN T P LE Rendu P Lakehal M | 2000 | 69 : 177-1812000，69，： | 1 |
| 9 | Primary radio- therapy for localized orbital MALT lymphoma 显示文摘 | Le Q T Eulau S M George T I | 2002 | hit J Radiat Oncol Biol Phys2002，52，3： | 1 |
| 10 | Behavioral and neuroendocrine effects of the exposure to chronic restraint or variable stress in early adolescent rats显示文摘 | CRUZ F C MARIN M T LE ~O R M | 2012 | International Journal of Developmental Neuroscience2012，30，1： | 1 |
| 11 | Characterization of Ba- cillus pmbiotics available for human use显示文摘 | Due le H Hong H A Barbosa T M | 2004 | Appl Environ Micro- biol2004，70，4： | 1 |
| 12 | ZSM-5 zeolite with enhanced acidic properties 显示文摘 | Le Van Mao R Le T S Fairbairn M | 1999 | Applied Catalysis A: General1999，185，： | 1 |
| 13 | Detection of inherited monazite in the Manaslu leucogranite by 208 Pb/232 Th ion microprobe dating:Crystallization age and tectonic significance 显示文摘 | HARRISION T M MCKEEGAN K D LE FORT P | 1995 | Earth and Planetary Science Letters1995，133，： | 1 |
| 14 | Least limiting water range:A potential indicator of changes in near-surface soil physical quality afterthe conversion of Brazilian Savanna into pasture显示文摘 | LEO T P DA SILVA AP MACEDO M C M | 2006 | Soil&Tillage Re-search2006，88，： | 1 |
| 15 | Selection of DNA aptamers with affinity for pro-gastrin-releasing peptide(pro GRP),a tumor marker for small cell lung cancer显示文摘 | Mie M Kai T Le T | 2013 | Appl Biochem Biotechnol2013，169，1： | 1 |
| 16 | Pre- dicting effects of cations on copper toxicity to lettuce (Lactuca sativa) by the biotic ligand model 显示文摘 | Le T T Y Peijnenburg W J G M Hendriks A J | 2012 | Environ- mental Toxicology and Chemistry2012，31，2： | 1 |
| 17 | Hormonal mechanism of dormancy induction in developing seeds显示文摘 | Le Page Degivry M T | 1998 | J Crop Production1998，1，1： | 1 |
| 18 | Changes in plasma cystatin C after renal transplantation and acute rejection in adult 显示文摘 | Le Briton T Thervet E Benlakehal M | 1999 | Clin Chem1999，45，12： | 1 |
| 19 | Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients显示文摘 | Le Q T Kovacs M S Dorie M J | 2003 | Int J Radiat Oncol Biol Phys2003，56，2： | 1 |
| 20 | On the variability of Cuora trifasciata (Bell,1825); the rediscovery of the type specimen,with descriptions of a new Cuora species and subspecies,and remarks on the distribution,habitat and vulnerability of these species (Reptilia:Testudines:Geoemydidae)显示文摘 | Blanck T WP McCord & M Le | 2006 | Edition Chimaira-Frankfurt Contributions to Natural History2006，31，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员