|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | A prospective study to compare the diagnostic performance of breast elastography versus conventional breast ultrasound显示文摘 | Leong LC Sim LS Lee YS | | 0，，11： | 1 |
| 3 | Mortality among psychiatric inpatients in Singapore显示文摘 | Lim LC Sim LP Chiam PC | 1991 | Singapore Medical Journal1991，32，3： | 1 |
| 4 | A prospective study to compare the diagnostic performance of breast elastography versus conventional breast ultrasound显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radiol2010，65，11： | 1 |
| 5 | A prospective study to compare the diagnostic performance of breast elastography versus conventional breast ultrasound 显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radiol2010，65，11： | 1 |
| 6 | A pro- spective study to compare the diagnostic per- formance of breast elastography versus con- ventional breast ultrasound 显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radi- al2010，65，11： | 1 |
| 7 | Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergy rhinitis 显示文摘 | WISLON AM ORR LC SIMS E J | 2001 | Clin Exp Allergy2001，31，1： | 1 |
| 8 | Effects of topical corticosteroid and combined mediator blockade on domiciliary and laboratory measurements of nasal function in seasonal allergic rhinitis显示文摘 | Wilson AM Sims EJ Orr LC | 2001 | Ann Allergy Asthma Immunol2001，87，4： | 1 |
| 9 | Pre-and post-exposure prophylaxis of experimental Burkholderia pseudomallei infection with doxycycline,amoxicillin/ clavulanic acid and cotrimoxazole显示文摘 | Sivalingam SP Sim SH Jasper LC | | 0，，03： | 1 |
| 10 | A prospective study to compare the diagnostic performance of breast elastography versus conventional breast ultrasound显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radiol2010，65，11： | 1 |
| 11 | A prospective study to compare the cliagnos- tic performance of breast elastography versus conventional breast ultrasound 显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radiol2010，65，11： | 1 |
| 12 | A prospective study to compare the diagnostic performance of breast elastography versus conven- tional breast ultrasound显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radiol2010，65，11： | 1 |
| 13 | A prospective study to compare the cliagnostic performance of breast elastography versus conventional breast ultrasound 显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radio12010，65，11： | 1 |
| 14 | A prospective study to compare thediagnostic performance of breast elastography versus conventionalbreast ultrasound显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radiol2010，65，11： | 1 |
| 15 | A prospective study to compare thediagnostic performance of breast elastography versus conventionalbreast ultrasound 显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radiol2010，65，11： | 1 |
| 16 | Antiasthmatic effects of mediator blockade versus topical corticosteroids in allergic rhinitis and asthma 显示文摘 | Wilson AM Orr LC Sims EJ | 2000 | Am J Respir Crit Car Med2000，162，4： | 1 |
| 17 | A prospective study to compare the diagnostic performance of breast elastography versus conventional breast ultrasound显示文摘 | Leong LC Sim LS Lee YS | 2010 | Clin Radiol2010，65，11： | 1 |
| 18 | Effects of intranasal corticosteroids on adrenal,bone,and blood markers of systemic activity in allergic rhinitis显示文摘 | Wilson AM Sims E J McFarlane LC | | 0，，4： | 1 |
| 19 | Chiam PC Mortality among psychiatric inpa-tients in Singapore显示文摘 | Lim LC Sim LP | 1991 | Singapore Medical Journal1991，32，3： | 1 |
| 20 | Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis显示文摘 | Wilson AM Orr LC Sims EJ | 2001 | Clin Exp Allergy2001，31，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员