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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Finite element analysis of tibial fractures显示文摘 | Wong C Mikkelsen P Hansen LB | | 0，，05： | 1 |
| 3 | Repro- ducibility of the Bath Ankylosing Spondylitis Indi- ces of Disease Activity (BASDAI), functional status (BASFI) and overall well-being (BAS-G) in anti-tumor necrosis factor-treated spondyloar- thropathy patients显示文摘 | Madsen OR Rytter A Hansen LB | 2010 | Clin Rheumatol2010，29，8： | 1 |
| 4 | Biological Cardiovascular Risk Factors Cluster in Danish Children and Adolescents:the European Youth Heart Study显示文摘 | Andersen LB Wedderkopp N Hansen KS | 2003 | Prev Med2003，7，： | 1 |
| 5 | Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and select- ed emetic bacteria 显示文摘 | Hansen LH Jensen LB Sorensen HI | 2007 | J Antimicreb Chemother2007，60，1： | 1 |
| 6 | Substrate specificity of the oqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria显示文摘 | Hansen LH Jensen LB Sorensen HI | 2007 | J Antimicrob Chemother2007，60，3： | 1 |
| 7 | Current approaches to the prevention and treatment of postmenopausal osteoporosis 显示文摘 | Follin SL Hansen LB | 2003 | Am J Health Syst Pharm2003，60，90： | 1 |
| 8 | Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria显示文摘 | Hansen LH Jensen LB Sorensen HI | 2007 | J Antimicrob Chemother2007，60，3： | 1 |
| 9 | Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria显示文摘 | Hansen LH Jensen LB Sφrensen HI | | 0，，01： | 1 |
| 10 | The Relationship between Physical Fimess and Clustered Risk,and Tracking of Clustered Risk from Adolescence to Young Adulthood:Eight Years Follow-up in the Danish Youth and Sport Study显示文摘 | Andersen LB Hasselstrom H Hansen SE | 2004 | Int J Behav Nutr Phys Fitness2004，1，： | 1 |
| 11 | Identification and mapping of linear antibody epitopes in human serum albumin using high-density peptide arrays显示文摘 | Hansen LB Buus S Schafer-Nielsen C | 2013 | PLoS One2013，8，68： | 1 |
| 12 | Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria显示文摘 | Hansen LH Jensen LB Sorensen HI | 2007 | J Antimicrobial Chemotherapy2007，60，3： | 1 |
| 13 | Current approaches to the prevention and treatment of postmenopausal osteoporosis显示文摘 | SL Follinand LB Hansen | 2013 | Am J Health-Syst Pharm2013，67，18： | 1 |
| 14 | Prevention and treatment of non- postmennpausal osteoporosis 显示文摘 | Hansen LB Vondracek SF | 2004 | Am Health Syst Pharm2004，61，24： | 1 |
| 15 | In vitro susceptibility of 4903 bacterial isolates to gemifloxacin-an advanced fluoroquinolone 显示文摘 | Hansen G Metzler KL Borsos S Irvine LB Blanco L | 2003 | Int J Antimicrob Agents2003，22，2： | 1 |
| 16 | Central giant cell lesions of the mandible and maxilla:A clinicopathologic and cytometric study显示文摘 | Ficarra G Kaban LB Hansen LS | 1987 | Oral Surg Oral Med Oral Pathol1987，64，： | 1 |
| 17 | Protein kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells 显示文摘 | Frankel LB Lykkesfeldt AE Hansen JB | 2007 | Breast Cancer Res Treat2007，104，2： | 1 |
| 18 | Future clinical phannacy practitioners should be board-certified specialists显示文摘 | Saseen J J Grady SE Hansen LB | 2006 | Pharmacotherapy2006，26，12： | 1 |
| 19 | Biological cardiovascular risk factors cluster in Danish children and adolescents: the European Youth Heart Study 显示文摘 | Andersen LB Wedderkopp N Hansen HS | 2003 | Preventive Medicine2003，37，： | 1 |
| 20 | Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria显示文摘 | Hansen LH Jensen LB Sorensen HI | | 0，，03： | 1 |
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