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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Acrylate and methacrylate esters:Relationship of hemolytic activity and in vivo toxicity显示文摘 | Dillingham EO Lawrence WH Autian J | | 0，，06： | 1 |
| 3 | Antifertility and mutsgenic effects in mice from parenteral administration of DEHP显示文摘 | Agarwal DK Lawrence WH Atitian J | 1985 | Toxicol Environ Heath1985，16，1： | 1 |
| 4 | Teratogenicity of phthalate esters in rats显示文摘 | Singh AR Lawrence WH Autian J | 1972 | J Pharm Sci1972，61，1： | 1 |
| 5 | Comparison of the cariogenicityof cola,honey,cow milk,human milk,and sucrose显示文摘 | Bowen WH Lawrence RA | 2005 | Pediatrics2005，116，4： | 1 |
| 6 | Teratogenicity of phthalate esters in rats显示文摘 | Singh AR Lawrence WH Autian J | 1972 | J Pharm Sci1972，61，： | 1 |
| 7 | Comparison of the cariogenicity of cola, honey, cow milk, human milk, sucrose 显示文摘 | Bowen WH Lawrence RA | 2005 | Pediatrics2005，116，4： | 1 |
| 8 | Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose 显示文摘 | Bowen WH Lawrence RA | 2005 | Pediatrics2005，116，4： | 1 |
| 9 | Enhancement of methotrexate absorption by subdivision of dose显示文摘 | Steele WH Stuart JF Lawrence JR | 1979 | Cancet chemother pharmacol1979，3，： | 1 |
| 10 | Binding of human chorionic gonadotropin by rat cumuli oophori and granulosa cells:a comparative study显示文摘 | Lawrence TS Dekel N Beers WH | 1980 | Endocrinology1980，106，4： | 1 |
| 11 | Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose显示文摘 | Bowen WH Lawrence RA | 2005 | Pediatrics2005，116，4： | 1 |
| 12 | Comparison of the cariogenici- ty of cola, honey,cow milk,human milk, and sucrose 显示文摘 | Bowen WH Lawrence RA | 2005 | Pediatrics2005，116，4： | 1 |
| 13 | Teratogenicity of phthalate esters in rats 显示文摘 | SINGH AR LAWRENCE WH AUTIAN J | 1972 | Journal of Pharmaceutical Sciences1972，61，1： | 1 |
| 14 | The molecular mechanics of P-selectin and L-selectin lectin domains binding to PSGL-1 显示文摘 | Rinko L J Lawrence MB Guilford WH | 2004 | Biophys J2004，86，1： | 1 |
| 15 | Evaluation of ubiquinone concentration and mitochondrial function relative to eerivastatin-indueed skeletal myopathy in rats 显示文摘 | SCHAEFER WH LAWRENCE JW LOUGHLIN AF | 2004 | Toxicol Appl Pharmacol2004，194，1： | 1 |
| 16 | Antifertility and muta-genic effects in mice from parenteral administration of di-2-ethylhexyl phthalate(DEHP)显示文摘 | Agarwal DK Lawrence WH Autian J | | 0，，01： | 1 |
| 17 | Comparison of tire cariogenieily of cola, honey, cow milk, human milk, and sucrose显示文摘 | Bowen WH Lawrence RA | 2005 | Pediatrics2005，116，4： | 1 |
| 18 | Binding of human chorionic gonadotropin by rat cumulus cophor and granulose cells 显示文摘 | Lawrence TS Dekel N Beers WH | 1980 | Endorcinol1980，106，： | 1 |
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