|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Incidental vocabulary acquisition in a second language: the construct of task-induced involvement显示文摘 | B Laufer J Hulstijn | 2001 | Applied Linguistics2001，，： | 13 |
| 2 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 3 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 4 | Avoidance of Phrasal Verbs—A Case for Contrastive Analysis显示文摘 | Menachem Dagut Batia Laufer | 1985 | Studies in Second Language Acquisition1985，，1： | 2 |
| 5 | Form-focused Instruction in Second Language Vocabulary Learning: A Case for Contrastive Analysis and Translation显示文摘 | Batia Laufer Nany Girsai | 2008 | Applied Linguistics2008，，4： | 2 |
| 6 | What Causes Avoidance in L2 Learning显示文摘 | Batia Laufer Stig Eliasson | 1993 | Studies in Second Language Acquisition1993，，1： | 2 |
| 7 | Antioxidative properties of the gastrointestinal phytopharmaceutical remedy STW 5 (Iberogast ? )显示文摘 | I. Germann D. Hagelauer O. Kelber B. Vinson S. Laufer D. Weiser H. Heinle | 2006 | Phytomedicine2006，，： | 2 |
| 8 | How should a company respond to a product harm crisis? The role of corporate reputation and consumer-based cues 显示文摘 | Laufer Daniel | 2006 | Business Horizons2006，49，5： | 1 |
| 9 | Examining the relationship between resilience and posttraumatic growth显示文摘 | Levine SZ Laufer A | 2009 | J Trauma Stress2009，22，4： | 1 |
| 10 | Ease and Difficulty in Vocabulary Learning:Some Teaching Implications显示文摘 | B | 1990 | Foreign Language Annals1990，，23： | 1 |
| 11 | Abacavir dose not influence the rate of sustained virological response in HIV-HCV co- infected patients treated with pegylated interferon and weight adjusted ribavirin显示文摘 | Laufer N Laguno M Perez I | 2008 | Antivir Ther2008，13，7： | 1 |
| 12 | Second Llanguage Vocabulary Acquisition from Language Input and from Form-focused Activities 显示文摘 | LAUFER B | 2009 | LanguageTcaching2009，42，3： | 1 |
| 13 | Taking the easy way out:Non-use and misuse of clues in EFL reading 显示文摘 | Laufer B & Sim D D | 1985 | English Teaching Forum1985，，232： | 1 |
| 14 | Who's to Blame?Differences in Consumer Attributions of Blame Between Men and Women:The Role of Perceived Vulnerability and Empathic Concern显示文摘 | LAUFER DANIEL KATE GILLESPIE | 2004 | Psychology and Marketing2004，，21： | 1 |
| 15 | The effect of displacement time on gingival crevice width显示文摘 | Baharav H Laufer BZ Langer Y | 1997 | Inter J Prosthodont1997，10，3： | 1 |
| 16 | Conservative management of bilateral asynchronous adnexal torsion with necrosis in a pre pubescent girl 显示文摘 | Eckler K Laufer M R Peflman S E | 2000 | J Pediatr Surg2000，35，8： | 1 |
| 17 | Synthesis of 7- hydroxycoumarins by Pechmann reaction using Nafion resin/ silica nanocomposites as catalysts显示文摘 | Laufer M C Hausmann H Holderich W F | 2003 | Journal of Catalysis2003，218，2： | 1 |
| 18 | Human papillonmavirus (HPV),HPV-related diseaso,and the HPV vaccine显示文摘 | Braaten K P Laufer M R | 2008 | Rev Obstet Gynecol2008，1，1： | 1 |
| 19 | Obstructed hemivagina and ipsilateral renal anomaly ( OHVIRA ) syndrome : management and follow- up显示文摘 | Smith NA Laufer MR | 2007 | Fertil Steril2007，87，： | 1 |
| 20 | Some empirical evidence for the involvement load hypothesis in vocabulary acquisi- tion 显示文摘 | Hulstijn J H & Laufer B | 2001 | Language Learning2001，53，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员