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| 1 | Risk factors for endophthalmitis following cataract surgery-our experience at a tertiary eye care centre in India显示文摘AIM: To determine the risk factors for acute endophthalmitis after cataract extraction in a tertiary care centre in India.·METHODS: We performed a nested case control study within a retrospective cohort. The surgical records of all patients with clinically diagnosed endophthalmitis within one month after cataract surgery, performed between January 2006 and December 2009, were reviewed. These were compared with randomly selected age and gender-matched controls, from patients having routine cataract surgery within ±1wk of the endophthalmitis case.Univariable and multivariable analysis were performed to identify risk factors for endophthalmitis.· RESULTS: Of the total 33 856 cataract surgeries performed during this period, there were 57 cases of postoperative acute endophthalmitis that met our study criteria. Thus, the overall incidence of endophthalmitis in our cohort was 1.6 per 1000 cataract extractions performed. Mean age of cases was 55.9y(SD: 10.9y) and for controls was 55.6y(SD: 9.8y). Thirty-five cases(61.4%)and 133 controls(59.6%) were males. Median time of onset of endophthalmitis was 4d(IQR 2-9d; range: 1-30d).Thirty-nine cases(68.4%) presented within 7d and 27 cases(47.4%) were culture positive. Two hundred and twenty-three age and gender matched controls were selected. In multivariate analysis, endophthalmitis was associated with posterior capsular rupture(PCR) during surgery(OR 6.98, 95%CI: 2.22-21.98), phacoemulsification via scleral incision with a foldable intraocular lens(IOL)implantation(OR 3.02, 95%CI: 1.13-8.04) and ocular comorbidity(OR 2.32, 95%CI: 1.11-4.87).·CONCLUSION: PCR, presence of ocular co-morbidity,and phacoemulsification via scleral incision with foldable-IOL were found to be independent risk factors for acute endophthalmitis. | Rohit C.Khanna Vanita Pathak Ray Madhavi Latha Sandra D Cassard Annie Mathai Garudadri C Sekhar | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 2 | Evaluation of ELISA based on the conserved and functional middle region of nucleocapsid protein to detect distemper infection in dogs显示文摘 | Latha D Geetha M Ramadass P | 2007 | Vet Microbiol2007，120，34： | 1 |
| 3 | Development of recombinant nuc|eocapsid protein based IgM-ELISA for the early detection of distemper infection in dogs 显示文摘 | Latha D Geetha M Ramadass P | 2007 | Vet Immunol Immunopathol2007，119，27： | 1 |
| 4 | Reduced T-Cell and Dendritic Cell Function Is Related to Cyc]ooxygenase-20verexpression and Prostaglandin E2 Secretion in Patients With Breast Cancer显示文摘 | Barbara A Pockaj Gargi D Basu Latha B Pathangey | 2004 | Ann Surg Oncol2004，11，3： | 1 |
| 5 | Improved PCR assay for the detection of canine parvovirus from faecal samples显示文摘 | Latha D Ramadass P | 2002 | Indian veterinary medical journal2002，26，4： | 1 |
| 6 | In vitro antioxidant effects of Trigonella foenum grae- cure (U) fenugreek seed extract on sheep red blood cells显示文摘 | VASUDEVAN D SUBHASHASHREE S LATHA P | 2012 | Journal of Medicinal Plants Research2012，6，38： | 1 |
| 7 | Accumulation of amyloid precursor protein in the mitochondrial Import channels of human alzheimer's disease brain is associated with mitochondrial dysfunction显示文摘 | Latha D Badanavalu M Prabhu | 2006 | Neuroscience2006，26，35： | 1 |
| 8 | Immunomodulatory and antitumour properties of Psoratea corylifolia seeds显示文摘 | Latha P G Evans D A Panikkar K R | 2000 | Fitoterapia2000，71，3： | 1 |
| 9 | Antiplas- mid activity of l'-acetoxychavicol acetate from Aipin- ia galanga against multi-drug resistant bacteria显示文摘 | Latha C Shriram V D Jahagirdar S S | 2009 | Journal of Ethnopharmacology2009，123，52： | 1 |
| 10 | Ovarian cancer biology and immunotherapy 显示文摘 | Latha T S Panati K Gowd D S | 2014 | Int Rev Immunol2014，33，5： | 1 |
| 11 | Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer 显示文摘 | Barbara A Gargi D Latha B | 2004 | Ann Surg Oncol2004，11，3： | 1 |
| 12 | Evaluation of ELISA based on the conserved and functional middle re- gion of nucleocapsid protein to detect distemper infection in dogs显示文摘 | LATHA D GEETHA M RAMADASS P | 2007 | Vet Microbiol2007，120，34： | 1 |
| 13 | Factors Relatedto Life Satisfaction, Meaning of Life, Religiosity and Death Anxiety inHealth Care Staff and Students: A Cross Sectional Study from India显示文摘 | LATHA K S SAHANA M MARIELLA D | 2013 | Online J Health Allied Sci2013，12，2： | 1 |
| 14 | Development of recombinant nucleocapsid protein based IgM-ELISA for the early detection of distemper infection in dogs 显示文摘 | Latha D Geetha M Ramadass P | 2007 | Vet Immunol Immunopathol2007，119，34： | 1 |
| 15 | A small molecule fibrokinase inhibitor in a model of fibropolycystic hepatorenal disease显示文摘AIM To evaluate the novel platelet-derived growth factor receptor and vascular endothelial growth factor receptor dual kinase inhibitor ANG3070 in a polycystic kidney disease-congenital hepatic fibrosis model.METHODS At 6 wk of age, PCK rats were randomized to vehicle or ANG3070 for 4 wk. At 10 wk, 24 h urine and left kidneys were collected and rats were continued on treatment for 4 wk. At 14 wk, 24 h urine was collected, rats were sacrificed, and liver and right kidneys were collected for histological evaluation. For Western blot studies, PCK rats were treated with vehicle or ANG3070 for 7 d and sacrificed approximately 30 min after the last treatments.RESULTS Compared to the wild-type cohort, the PCK kidney(Vehicle cohort) exhibited a marked increase in kidney and liver mass, hepato-renal cystic volume, hepato-renal fibrosis and hepato-renal injury biomarkers. Intervention with ANG3070 in PCK rats decreased kidney weight, reduced renal cystic volume and reduced total kidney hydroxyproline, indicating significantly reduced rental interstitial fibrosis compared to the PCK-Vehicle cohort. ANG3070 treatment also mitigated several markers of kidney injury, including urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, cystatin C and interleukin-18 levels. In addition, this treatment attenuated key indices of renal dysfunction, including proteinuria, albuminuria and serum blood urea nitrogen and creatinine, and significantly improved renal function compared to the PCK-Vehicle cohort. ANG3070 treatment also significantly decreased liver enlargement, hepatic lesions, and liver fibrosis, and mitigated liver dysfunction compared to the PCK-Vehicle cohort.CONCLUSION These results suggest that ANG3070 has the potential to slow disease, and may serve as a bridge toward hepato-renal transplantation in patients with fibropolycystic disease. | Prani Paka Brian Huang Bin Duan Jing-Song Li Ping Zhou Latha Paka Michael A Yamin Scott L Friedman Itzhak D Goldberg Prakash Narayan | 2018 | World Journal of Nephrology2018，7，5： | 1 |
| 16 | Thermal creep properties of alloy D9 stainless steel and 316 stainless steel fuel clad tubes 显示文摘 | Latha S Mathewa M D Parameswaran P | 2008 | International Journal of Pressure Vessels and Piping2008，85，： | 1 |
| 17 | Physico -chemical chan- ges in rice bran oil during heating at frying temperature 显示文摘 | LATHA R B NASIRULIAH D R | 2014 | J Food Sci Technol2014，51，2： | 1 |
| 18 | Evaluation of ELISA based on the conserved and functional middle region of nucleocapsid protein to detect distemper in- fection in dogs 显示文摘 | Latha D Geetha M Ramadass P | 2007 | Vet Microbiol2007，120，34： | 1 |
| 19 | Immunomodulatory and antitumour properties of Psoralea corylifolia seeds 显示文摘 | Latha P G Evans D A Panikkar K R | 2000 | Fitoterapia2000，71，3： | 1 |
| 20 | Anti B cell targeted therapy for autoimmune hemolytic anemia in an infant 显示文摘 | Makadia D Siddaiahgari SR Latha MS | 2013 | Indian J Pharma- col2013，45，5： | 1 |
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