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| 1 | Is early limited surgery associated with a more benign disease course in Crohn's disease?显示文摘AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. | Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 2 | NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients显示文摘AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations. | Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，41： | 2 |
| 3 | Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012显示文摘AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province.METHODS: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses.Early CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease course.CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization. | Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz Zsuzsanna Vegh Zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | Synthesis of glyeyrrhetinic acid deriva- tives for the treatment of metabolic diseases 显示文摘 | Igor B Laszlo C Priti S | 2010 | Bioorg Med Chem2010，18，1： | 1 |
| 5 | Catalysis of the Knoevenagel condensations显示文摘 | Laszlo P Mathy A | 1985 | Tetrahedron Lett1985，26，37： | 1 |
| 6 | Regulation of colony stimu- lating factor-1 expression and ovarian cancer cell behavior in vitro by miR-128 and miR-152显示文摘 | Woo HH Laszlo CF Greco S | 2012 | Mol cancer2012，11，： | 1 |
| 7 | Electrical cardioversion for atrial fibrillation 显示文摘 | Laszlo R Laszlo S Graze H | 2010 | Dtsch Med Wocbenschr2010，135，15： | 1 |
| 8 | A scanning infrared technique for cigarette coal peak temperature measurements显示文摘 | LASZLO T S WATAON F M | 1974 | Beitr Tabakforsch1974，7，： | 1 |
| 9 | Clinical predictors of intractable childhood epilepsy显示文摘 | Aithala G Laszlo S Joseph H | 2006 | J Psycho Res2006，61，： | 1 |
| 10 | Cigarette peak coal temperature measurements 显示文摘 | LASZLO T S LENDVAY A T | 1974 | Beitr Tabakforsch1974，7，： | 1 |
| 11 | Cadmium accumulation and distribution in sun-flower plant 显示文摘 | Laszlo S | | Journal of Plant Nutrition0，21，2： | 1 |
| 12 | Trainable blotch detection on high resolution archive films minimizing the human interaction显示文摘 | Attila L Tamas S Laszlo D | 2010 | Machine Vision and Applications2010，21，5： | 1 |
| 13 | Miniimum spanning tree partitioning algorithm for microaggregation显示文摘 | LASZLO M MUKHERJEE S | | 0，，07： | 1 |
| 14 | Randriamahefa catalysis of the specific michael addition: the example of acrylate acceptors 显示文摘 | Cabral J Laszlo P Montaufier S L | 1989 | Tetrahedron Lett1989，30，： | 1 |
| 15 | 查看详情显示文摘 | Laszlo S Som A Faust R | | 0，，05： | 1 |
| 16 | A genetic algorithm that ex- changes neighboring centers for k-means clustering 显示文摘 | Laszlo M Mukherjee S | 2007 | Pattern Recognition Letters2007，28，16： | 1 |
| 17 | A genetic algorithm that exchanges neighboring centers for K-means clustering显示文摘 | Laszlo M Mukherjee S | 2007 | Pattern Recognition Letters2007，28，16： | 1 |
| 18 | Pyrroles and other heterocycles as inhibitors of p38 kinase显示文摘 | De LASZLO S E VISCO D AQARWAL L | 1998 | Bioorg Med Chem Lett1998，8，19： | 1 |
| 19 | Anger expression and prognosis af- ter a coronary event in women 显示文摘 | Laszlo KD Janszky I Ahnve S | 2010 | Int J Cardiol2010，140，1： | 1 |
| 20 | High expression of suppressor of cytokine signaling-2 predicts poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group 显示文摘 | Laszlo G S Ries R E Gudgeon C J | 2014 | Leukemia & lymphoma2014，55，12： | 1 |
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