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| 1 | Anterior limb lesions in bilateral internal capsules and memory function in patients with refractory obsessive-compulsive disorder显示文摘BACKGROUND: Previous studies have shown that lesions in the anterior limb of the internal capsule contribute to obsessive-compulsive symptoms in patients with refractory obsessive-compulsive disorder (OCD). However, few reports have addressed the effects of lesions in the anterior limb of the internal capsule on cognition, learning, and memory functions in patients with refractory OCD. OBJECTIVE: To investigate the degree of damage to memory tasks in refractory OCD patients following lesions to the anterior limb of the internal capsule. DESIGN, TIME AND SETTING: A case-controlled, observational study was performed at the Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao-Tong University, China from May 2007 to March 2008. PARTICIPANTS: A total of 10 refractory OCD patients were admitted to the Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao-Tong University, China from May 2007 to March 2008 and were recruited for this study. The OCD patients were of equal gender, with an average age of (25.1 ± 9.6) years. An additional 10 healthy volunteers were enrolled from a community of Shanghai City as controls; they were of equal gender and aged (25.1 ± 8.6) years. METHODS: A total of 10 refractory OCD patients were subjected to lesions in the anterior limbs of the bilateral internal capsules. Wechsler Memory Scale–Chinese Revision (WMS-CR, as a task of explicit memory) and the Nissen Version (serial reaction time task) software (SRTT, as a task of implicit memory) were applied to determine memory functions and learning performance in pre- and post-operative OCD patients and controls. MAIN OUTCOME MEASURES: WMS scores, reaction time in SRTT, and Yale-Brown obsessive compulsive scale scores were measured in pre- and post-operative OCD patients and controls. RESULTS: Compared to controls, the pre-operative OCD patients exhibited reduced memory task scores (P = 0.005), whereas scores for reciting numbers of backwards digits were greater (P = 0.000). Figure recall and associative memory were less in OCD patients at 1 week following surgery than in the pre-operative OCD patients (P = 0.042, P = 0.002, respectively). Reaction time in implicit SRTT was significantly longer in pre-operative OCD patients compared with controls and post-operative OCD patients (P = 0.01, P = 0.03, respectively). These results suggested ameliorated SRTT following neurosurgery. Yale-Brown Obsessive Compulsive Scale results revealed significantly improved OCD following lesions in the internal capsule (P = 0.04). Some post-operative OCD patients suffered from deficits in short-term memory and implicit memory. CONCLUSION: Lesions in anterior limbs of bilateral internal capsules improve obsessive-compulsive symptoms and implicit memory in OCD patients, but result in aggravated short-term memory deficits. | Yumei Jiang Bomin Sun Xiaoping Wang Weifeng Zhang Xinfeng Zhao Lassonde MO | 2010 | Neural Regeneration Research2010，5，12： | 2 |
| 2 | 基于神经心理学的功能神经影像学研究进展显示文摘当前神经心理学以及认知神经科学用整体的系统方法论来观察人类认知的过程,其中对人脑的内在神经过程的探索,除了临床神经心理学测试等方法外,则需要利用'声光电磁'等物理技术及数学模型三维再建。该文综述了功能磁共振和事件相关电位在功能神经影像学的活体功能解剖学观察中的应用,尤其是两者结合同步研究技术。 | 王晓平 Lassonde M 王俊峰 | 2009 | 上海交通大学学报(医学版)2009，29，6： | 2 |
| 3 | EEG spectral analysis in wakefulness, REM andNREM sleep following sport-related concussions 显示文摘 | Gosselin N’Lassonde M Petit D Leclerc S Mongrain V Mont-plaisir J | 2007 | Sleep2007，，： | 1 |
| 4 | The contribution of functional near-infrared spectroscopy (fNIRS) to the presurgical assessment of language function in children显示文摘 | GALLAGHER A BELAND tR LASSONDE M | | 0，，02： | 1 |
| 5 | On the use of KKM multimaps in fixde point theory and related topics显示文摘 | LASSONDE M | 1983 | J Math Anal Appl1983，97，： | 1 |
| 6 | Psychological stress and psoriasis: experimental and prospective correlational studies 显示文摘 | Gaston L Crombez J C Lassonde M | 1991 | Acta Derm Venereal Suppl ( Stockh)1991，156，： | 1 |
| 7 | On the Use of KKM Multifunctions in Fixed Point Theory and Related Topics 显示文摘 | Lassonde M | 1983 | J Math Anal Appl1983，97，1： | 1 |
| 8 | Prevalence of nonlesional focal epilepsy in an adult epilepsy clinic显示文摘 | Lassonde M Nguyen DK Mbacfou MT | 2013 | Can J Neurol Sci2013，40，2： | 1 |
| 9 | Neuropsychology of childhood epilepsy: pre-and postsurgical assessment显示文摘 | Lassonde M Sauerwein HC Jambaquel | 2000 | Epileptic Disord2000，2，： | 1 |
| 10 | A functional neuroimaging study of sound localization: Visual cortex activity performance in early-blind individuals显示文摘 | Gougoux F Zatorre RJ Lassonde M | 2005 | PloS Biology2005，3，： | 1 |
| 11 | Sensorimotor organization in patients who have undergone hemispherectomy: a study with (15) O-water PET and somatosensory evoked potentials显示文摘 | Bernasconi A Bernasconi N Lassonde M | 2000 | Neuroreport2000，11，14： | 1 |
| 12 | On the use of KKM multifunctions in fixed point theory and related topics显示文摘 | Lassonde M | 1983 | J Math Anal Appl1983，97，1： | 1 |
| 13 | Early visual deprivation alters multisensory processing in peripersonal space显示文摘 | Collignon O Charbonneau G Lassonde M | 2009 | Neuropsychologia2009，47，： | 1 |
| 14 | Sensory and motor involvement in the enhanced redundant target effect:A study comparing anterior-and totally split-brain individuals显示文摘 | Ouimet C Jolicoeur P Miller J Ptito A Paggi A Foschi N Lassonde M | | 0，，： | 1 |
| 15 | On the use of KKM multimaps in fixed point theory and related topics显示文摘 | Lassonde M | 1983 | J Math Anal Appl1983，97，： | 1 |
| 16 | On the use of KKM multifunctions in fixed point theory and related topics显示文摘 | Lassonde M | 1983 | J Math Anal Appl1983，97，： | 1 |
| 17 | On the use of KKM multifunctions in fixed point theory and related topics显示文摘 | Lassonde M | 1983 | J Math Anal Appl1983，97，： | 1 |
| 18 | Fixed points foe Kakutani faetorizable multifunetions显示文摘 | Lassonde M | 1990 | J Math Anal Appl1990，152，1： | 1 |
| 19 | On the use of KKM multifunctions in fixed point theory and related topics显示文摘 | Lassonde M | 1983 | J Math Anal Appl1983，97，： | 1 |
| 20 | Mild traumatic brain injury: neuroimaging of sports-related concussion 显示文摘 | Mendez CV Hurley RA Lassonde M | 2005 | J Neuropsychiatry Clin Neurosci2005，17，3： | 1 |
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