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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Menopause and cognitive impairment:A narrative review of current knowledge显示文摘A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition. | Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva | 2021 | World Journal of Psychiatry2021，11，8： | 3 |
| 3 | Single sheet functionalized graphene by oxidation and thermal expansion of graphite显示文摘 | Mcallister M J Lio J L Adamson D H | 2007 | Chem Mater2007，19，18： | 1 |
| 4 | Parameter Estimations for Generalized Exponential Distribution under Progressive Typo-I Interval Censoring 显示文摘 | Chen D G Lio Y L | 2010 | Computational Statistics and Data Analysis2010，，54： | 1 |
| 5 | Inflammation, genetics, and longevity: further studies on the pro- tective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alpha-308 promoter SNP 显示文摘 | Lio D Scola L Crivello A | 2003 | J Med Genet2003，40，4： | 1 |
| 6 | Spontaneous Phase and Morphology Transformations of Anodized Titania Nanotubes Induced by Water at Room Temperature 显示文摘 | Wang D Lio L Zhang F Tao K Pippel E Domen K | 2011 | Nano letters2011，11，9： | 1 |
| 7 | Gender-specific association between 1082 IL-1O promoter polymorphism and lon- gevity显示文摘 | Lio D Scola L Crivello A | 2002 | Genes Immun2002，3，1： | 1 |
| 8 | Allele frequencies of +874T:a single nucleotide polymorphism at the first intron of IFN-γ gene in a group of Italian centenarians expression显示文摘 | Lio D Scola L Crivello A | 2002 | Gerontology2002，37，23： | 1 |
| 9 | Single sheet funetionalized graphene by oxidation and thermal ex- pansion of graphite显示文摘 | MCALLISTER M J LIO J L AAMSON D H | 2007 | Chem Mater2007，19，18： | 1 |
| 10 | A holistic approach to the integration of safety applications:The INSAFES subproject within the European framework programmne 6 integrating project PReVENT显示文摘 | AMDITIS A BERTOLAZZI E BIMPAS M BIRAL F BOSETTI P LIO D M DANIELSSON L GALLIONE A LIND H SAROLDI A SJOGREN A | | 0，，03： | 1 |
| 11 | Genome restructuring in rye affects the expression,organization and disposition of homologous rDNA loci显示文摘 | Caperta A D Neves N Morais-Cecílio L Malhó R Viegas W | | 0，，： | 1 |
| 12 | Chromosome alterations associated with positive and negative lymph node involvement in breast cancer显示文摘 | Wuicik L Cavalli L Cornélio D | 2007 | Cancer Genetics and Cytogenetics2007，173，： | 1 |
| 13 | TNFa, IFNγ and IL-10 gene polymorphisms in a sample of Sicilian patients with coeliac disease 显示文摘 | Lio D Scola L Forte G I | 2005 | Digest Liver Dis2005，37，10： | 1 |
| 14 | Interleukin-l0 promoter polymor?phism in sporadic Alzheimer's disease 显示文摘 | Lio D Licastro F Scola L | 2003 | Genes Immunity2003，4，3： | 1 |
| 15 | Association between platelet endothelial cellular adhesion molecule-1(PECAM-1/CD31)polymorphisms and acute myocardial infarction:a study in patients from Sicily显示文摘 | Listi F Candore G Lio D Cavallone L Colonna-Romano G Caruso M | 2004 | Eur J Immunogenet2004，31，： | 1 |
| 16 | Single sheet functionalized graphene by oxidation and thermal expansion of graphite 显示文摘 | MCALLISTER M J LIO J L ADAMSON D H | 2007 | Chemistry of Materials2007，19，18： | 1 |
| 17 | Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-αlpha-308 promoter SNP 显示文摘 | Lio D Scola L Crivello A | 2003 | J Med Genet2003，40，4： | 1 |
| 18 | Parameter estimations for generalized exponential distribution under progressive type-I interval censoring 显示文摘 | Chert D G Lio Y L | 2010 | Computational Statistics and Data Analysis2010，54，： | 1 |
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