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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Production of free fatty acids from waste oil by application of ultrasound 显示文摘 | Larissa P L Francisco F S Enio C | 2012 | Biomass Conversion and Biorefinery2012，，2： | 1 |
| 3 | Eucalyptus hydrolysate detoxification with activated charcoal adsorption or ion-exchange resins for xylitol production显示文摘 | LARISSA C BATISTA A S SOLENZAL A I N | 2004 | Process Biochemistry2004，39，： | 1 |
| 4 | Lobar holoprosencephaly:prenatal MR diagnosis withpostnatal MR correlation显示文摘 | Alex M Wong C Larissa T Bilaniuk K.-K.Ng | | 0，，04： | 1 |
| 5 | Beyond traditional surveillance:applying syndromic surveillance to developing settings-opportunities and challenges显示文摘 | Larissa M Jean C Julie P | | 0，，1： | 1 |
| 6 | The MTT cell viability assay for cytotoxicity testing in multidrug-resistant human leukemic cells 显示文摘 | Denese C Larissa Belov Mary W | 1992 | Leukemic Res1992，12，62： | 1 |
| 7 | Census of the Viral Metagenome within an Activated Sludge Microbial Assemblage显示文摘 | Larissa C P Erin J C Stephen J | 2010 | Applied and Environmental Microbiology2010，76，8： | 1 |
| 8 | Sarcol endoplasmic reticulum Ca2+ -ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat显示文摘 | Federicadel M Thierry C | 2005 | Circ Res2005，97，： | 1 |
| 9 | Sarcoplasmic reticulum Ca^2+ ATPase as a therapeutic target for heart failure 显示文摘 | Larissa Lipskaia Elie R C Lahouaria H et at | 2010 | Expert Opin Biol Ther2010，10，1： | 1 |
| 10 | Associations of FASN gene polymorphisms with economical traits in Nellore cattle 显示文摘 | Fabio R P S Milena G C Larissa F S F | 2012 | Molecular Biology Reports2012，39，10： | 1 |
| 11 | A study on xylitol produc- tion from sugarcane bagasse hemicellulosic hydrolysate by Ca-alginate entrapped cells in a stirred tank reactor显示文摘 | Carvalho W Silva S S Larissa C | 2004 | Process Biochem- istry2004，39，12： | 1 |
| 12 | How factors of land use/land cover,building configuration,and adjacent heat sources and sinks explain Urban Heat Islands in Chicago显示文摘 | PAUL C LARISSA L | 2014 | Landscape and Urban Planning2014，125，： | 1 |
| 13 | Nanoaggregates of copper porphyrazine in floating layers and Langmuir- Schaefer films 显示文摘 | Larissa A V Ludovico V Serena C | 2008 | Langmuir2008，24，9： | 1 |
| 14 | Method development by GC-ECD and HS-SPME-GC- MS for beer volatile analysis 显示文摘 | Gisele C Abner A S Larissa S N | 2015 | Food Chemistry2015，167，15： | 1 |
| 15 | Redox-switching of nonlinear optical behavior in Langmuir-Blodgett thin films containing a ruthenium (II) ammine complex 显示文摘 | Larissa A V Ludovico V Serena C | 2008 | J Am Chem Soc2008，130，11： | 1 |
| 16 | Dilute-acid hydrolysis of sugarcane bagasse at varying conditions 显示文摘 | LARISSA C VICTOR T O S GEORGE J M R | 2002 | Appl Biochem Biotechnol2002，，： | 1 |
| 17 | Deter- mination of diltiazem based on the reduction of Cu (Ⅱ)-BCA complexes in micellar medium显示文摘 | SABINO LARISSA Z L MARINO DANIELE C MOYA H D | 2010 | Canadian Journal of Chemistry2010，88，6： | 1 |
| 18 | Edible films made from blends of manioc starch and gelatine-Influence of different types of plasticizer and different levels of macromole- cules on their properties显示文摘 | Farayde M F Silvia M M Larissa C B | 2012 | LWT-Food Science and Teehnology2012，49，： | 1 |
| 19 | Structural changes of potassium-saturated smectite at high pressures and high temperatures: Application for subduction zones显示文摘 | Larissa C C Rommulo V C Norberto D | 2014 | Applied Clay Science2014，102，： | 1 |
| 20 | Edible filmsmade from blends of manioc starch and gelatine-Influence ofdifferent types of plasticzer and different levels of macromoleculestheir properties显示文摘 | Farayde M F Silvia M M Larissa C B | 2012 | LWT-Food Science and Technology2012，49，1： | 1 |
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