|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Langerin在Langerhans细胞组织细胞增生症和非Langerhans细胞组织细胞性疾病中的表达显示文摘 | Lan S K Chu P G Weiss L M 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，5： | 23 |
| 2 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 3 | Noncoherent sequential acquisition of PN sequence for DS/SS communications with/without dhannel fading显示文摘 | TANTARTANS S LAN A W VINCENT P J | 1995 | IEEE Trans on COM1995，43，2： | 2 |
| 4 | Phytoplankton functional groups as indicators of human impacts along the River Loire (France)显示文摘 | András Abonyi Maria Leit?o Anne Marie Lan?on Judit Padisák | 2012 | Hydrobiologia2012，，1： | 2 |
| 5 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 6 | Douglas gemmill: determining fabrication orientations for rapid prototyping with stereolithography apparatus显示文摘 | Lan P T Chon S Y Chen L L | 1997 | Computer-Aided Design1997，29，1： | 2 |
| 7 | Telomerase activity in pleural effusions diagnostic significance显示文摘 | CHENG T Y LEE M H LAN R S | 1998 | J Clin Oncol1998，16，4： | 2 |
| 8 | The application of SHRIMP to Phanerozoic geochronology: a critical appraisal of four zircon standards显示文摘 | Lance P Black Sandra L Kamo lan S Williams | 2003 | Chemical Geology2003，200，： | 1 |
| 9 | Resonant vibration behavior of Sn-Zn-Ag solder alloys显示文摘 | Song J M Lui T S Lan G F | 2004 | Journal of Alloys and Compounds2004，379，12： | 1 |
| 10 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 11 | Pdx-1 modulates Histone H4 aeetylation and insulin gene expression in terminally differentiated α- TC-1 cells 显示文摘 | Wang H W Breslin M B Lan M S | 2007 | Pancreas2007，34，2： | 1 |
| 12 | Hypoxanthine (HX) inhibition of in vitro meiotic resumption in goat oocytes 显示文摘 | Ma S Lan G Miao Y | 2003 | Mol Reprod Dev2003，66，3： | 1 |
| 13 | Enhancement of unidirectional transmission through the coupling of nonlinear photonic crystal defects 显示文摘 | Lin X S Lan S | 2006 | Optics Express2006，14，6： | 1 |
| 14 | Real-Time Noncrosstalk Sonar Sys|em by Short Optimized Pulse Position Modulation Sequences 显示文摘 | Meng Q H Lan S Y Yao Z J | 2009 | IEEE Transactions on Instrumentation and Measurement2009，58，10： | 1 |
| 15 | Association of the interleukin-2 polymorphisms with interleukin-2 serum levels and risk of ha- sopharyngeal carcinoma显示文摘 | Wei Y S Lan Y Zhang L | 2010 | DNA Cell Biol2010，29，7： | 1 |
| 16 | Dual lixiviant leaching process for extraction and re- covery of gold from ores at room temperature 显示文摘 | Zhang J T Shen S B Cheng Y Lan H F Hu X Wang F | 2014 | Hy- drometallurgy2014，144，145： | 1 |
| 17 | Macrophages promoterenal fibrosis through direct and indirect mechanisms显示文摘 | Nikolic-Paterson DJ Wang S Lan HY | 2014 | Kidney Int Suppl2014，4，1： | 1 |
| 18 | Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China 显示文摘 | Wang Y C Zhang H Y Xia N S Peng G Lan H Y Zhuang H Zhu Y H Li S W Tian K G Gu W J Lin W J Wu J X Li X Harrison T J | 2002 | Journal of Medical Virology2002，67，4： | 1 |
| 19 | New constructions of quasi - cyclic LDPC codes based on special classes of BIBD's for the AWGN and binary erasure channels 显示文摘 | Lan L Tai Y Y Lin S | 2008 | IEEE Transactions on Communications2008，56，1： | 1 |
| 20 | Thiopental- induced neutropenia in two patients with severe head trauma显示文摘 | Frenette A Perreault MM Lan S | 2007 | Pharmacotherapy2007，27，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员