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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Expression ofa reflex of snapping/biting response to amino acids prior to the first exogenous feeding in salmonid alevins显示文摘 | Valentin(c)i(c) T B Lamb C F Caprio J | 1999 | Physiol Behav1999，67，4： | 1 |
| 3 | Reverse genetics of negative-strand RNA viruses:Closing the circle显示文摘 | Pekosz A He B Lamb R A | 1999 | Proc Natl Acad Sci1999，96，16： | 1 |
| 4 | Use of the Dumon Y- stent in the management of malignant disease involving the carina:a retrospective review of 86 patients 显示文摘 | Dutau H Toutblanc B Lamb C | 2004 | Chest2004，126，3： | 1 |
| 5 | Sulfur emissions to the atmosphere from natural sources显示文摘 | Bate T S Lamb B K Guenther A | 1992 | Journal of Atmospheric Chemistry1992，14，： | 1 |
| 6 | A novel Pd/MgAlOx catalyst for NOX storage-reduction显示文摘 | SILLETTI B A ADAMS R T SIGMON S M NIKOLOPOULOS A SPIVEY J J LAMB H H | 2006 | Catal Today2006，114，1： | 1 |
| 7 | Melanoma,thyroid,cervical,and colon cancer risk after use of fertility drugs显示文摘 | ALTHUIS MD SCOCCIA B LAMB EJ | 2005 | Am J Obstet Gynecol2005，193，31： | 1 |
| 8 | Flagellate erythema induced by docetaxel 显示文摘 | Tallon B Lamb S | 2008 | Clin Exp Dermatol2008，33，3： | 1 |
| 9 | XPS determination of the forms of nitrogen in coal pyrolysis chars 显示文摘 | GONG B BUCKLEY A N LAMB R N NELSON P F | 1999 | Sur Int Anal1999，28，1： | 1 |
| 10 | Assessment of food intake input distributions for use in probabilistic exposure assessments of food additives 显示文摘 | Gilsenan M B Lambe J Gibney M J | 2003 | Food Additives and Contaminants2003，20，11： | 1 |
| 11 | The removal of carbon monoxide from air显示文摘 | Lamb A B Bray W C Frazer J C W | 1920 | Ind Eng Chem1920，12，3： | 1 |
| 12 | Sulfur emissions to the atmosphere from natural sources显示文摘 | BATES T S LAMB B K GUENTHER A | 1992 | Journal of Atmospheric Chemistry1992，14，14： | 1 |
| 13 | Bringing emerging technologies to market: does academic research promote commercial exploration and exploitation 显示文摘 | TEGARDEN L F LAMB W B HATFIELD D E | 2012 | Engineering Management IEEE Transactions2012，59，4： | 1 |
| 14 | Assessment of diastolic function by cardiovascular magnetic resonance 显示文摘 | PAELINCK B P LAMB H J BAX J J | 2002 | Am Heart J2002，144，2： | 1 |
| 15 | An open label study of the effects of rituximab in neuromyelitis optica显示文摘 | CREE B A LAMB S MORGAN K | 2005 | Neurology2005，64，7： | 1 |
| 16 | Information transfer and communication in surgery: A systematic review显示文摘 | NAGPAL K VATS A LAMB B | 2010 | Annals of Surgery2010，252，2： | 1 |
| 17 | DNA Fingerprints from Hypervariable Mitochondrial DNA Genotypes 显示文摘 | AVISE J C BOWEN B W LAMB T | 1989 | Molecular Biology and Evolution1989，6，： | 1 |
| 18 | Alkaloids : an overview of their antibacterial, antibiotic-enhancing and antivirulenceactivities 显示文摘 | Cushnie T P T Cushnie B Lamb A J | 2014 | Int J Antimicrob Agents2014，44，5： | 1 |
| 19 | Use of the Dumon Ystent in the management of malignant disease involving the carina:a retrospective review of 86 patients显示文摘 | Dutan H Touthlanc B Lamb C | 2004 | Chest2004，126，： | 1 |
| 20 | Friction properties of DLC/DLC contacts in base oil显示文摘 | VENGUDUSAMY B MUFTI R A LAMB G D | 2011 | Tribology Inter- national2011，44，78： | 1 |
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